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Weight-loss drug found to shrink muscle in mice, human cells

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Re: Weight-loss drug found to shrink muscle in mice, human cells

#141

Post by llamaimperative »

astura wrote: post #135
llamaimperative wrote: post #63

Earlier quoted context omitted.

> The rather obvious problem is that these GLP1 agonists don't improve your diet My understanding from initial anecdotes is this is actually literally wrong. Which was surprising to me, too. But people on GLPs tend to prefer more nutritious food (high protein and high fiber). I'm not sure if this has been studied directly in clinical trials yet but I know that food manufacturers have been reorienting their products t…

>My understanding from initial anecdotes is this is actually literally wrong. Which was surprising to me, too. But people on GLPs tend to prefer more nutritious food (high protein and high fiber). Not only that but prescribers and patients have noticed that GLP-1 agonists also appear to significantly reduce people's consumption of drugs like alcohol, nicotine and opioids. At least in some populations. Much more resea…

Yep! So far it looks like GLPs might just be a generic "craving-reducer." Pretty wild stuff if it holds (and we continue not to see significant adverse effects).

Re: Weight-loss drug found to shrink muscle in mice, human cells

#143

Post by renewiltord »

twelve40 wrote: post #76
renewiltord wrote: post #45

Earlier quoted context omitted.

One of my friends has tried many fad diets, etc. and he finally just went and paid cash for a GLP-1 and he's lost a lot of weight and is feeling much better. If I were in that situation, I would just do the same.

bringing it down is not even half the battle, it's what happens next is the more interesting part

These drugs are like psychedelics. There are lots of non users talking about them like they know them but all they did is read stuff in popular media.

My friend cut usage after he lost weight and finds maintenance easy.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#144

Post by hnthrowaway0328 »

andy_ppp wrote: post #54
hnthrowaway0328 wrote: post #35

Earlier quoted context omitted.

Thanks, that's good enough. I have been going to weight loss for over 6 months but I'm stuck between 79 and 80kg. It's a bit difficult to add more weight lifting because I tended to hurt myself, so eat less is better.

Add walking for 2h per day is the recommended I’ve seen.

Thanks, 2h is a bit too much for me, so what I do is about 3-4 10-12 mins walk-sprint walk reps. Basically half walk (3.5m/h) and half sprint-walk (4.4m/h). I wish I could do more but my joints are not really good.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#145

Post by _heimdall »

NotYourLawyer wrote: post #132
talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

To be fair, that comment was about the claim: > emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle Which is… obviously bullshit.

The source article links to a reference for the 40 percent claim, which itself links to a couple articles that aren't available without a JAMA account.

I can't read the original sources there, but what makes you say its obviously bullshit?

Re: Weight-loss drug found to shrink muscle in mice, human cells

#146

Post by NoPicklez »

cm2187 wrote: post #13

> emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle That's the sort of headlines that smells like bullshit to me. My understand of those drugs is that they don't actually make you lose weight, they just cut your appetite so you can follow a diet to lose weight without hunger hammering at the door. So to start with, if that's the case, all they are…

The article does dissect the difference between weight loss drugs and dieting in general. Where they found that muscle mass loss was higher in those that took the drug as opposed to those who followed a calorie restricted diet.

To your point, the drug is absolutely to do with it if by taking the drug people need to be more mindful of the types of food they eat, if they have a smaller window to consume nutrients.

It is most certainly a contributor and for some who may not exercise like you, or consume an appropriate level of protein this research may show that those taking the drug need to focus on a more protein right diet.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#147

Post by zzz999 »

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

[dead]

Re: Weight-loss drug found to shrink muscle in mice, human cells

#148

Post by elashri »

patrickhogan1 wrote: post #128
elevatedastalt wrote: post #118

Earlier quoted context omitted.

The HN you are yearning for disappeared about 8-10 years ago when it was largely taken over by normies and people way outside the hard-core-tech fold. It's not very different from Reddit front-page now if the topic is even remotely political. For purely technical topics you expect good quality discussion, but those threads barely get comments in the two digits.

Yes sometimes the loudest voice definitely rises to the top and it’s annoying, but I also think it’s a condition that too many new members don’t know how to use the upvote button. I also think it’s a symptom that HN does not allow enough people to use the down vote button. you could be a commenting member for years and not be able to downvote or you could be somebody who posts a few click bate links you copied from a…

From my observation it is hard to get to 501 karma points by the karma gained from submissions than through comments. So for comments every 1 upvote equals 1 karma. But for submissions, god only know what is the conversion rate /s. I think there are many factor. But I think this mechanism is to limit people creating accounts and mass down voting anything they don't like. So it is trying to solve another problem. However upvote power should be limited for new accounts (I don't know if this already the case)

Re: Weight-loss drug found to shrink muscle in mice, human cells

#149

Post by dluan »

devmor wrote: post #123
talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

After I saw yesterday’s thread about politics in science was flooded with new sockpuppet accounts named after slurs spreading filth and downing everything they don’t agree with I no longer expect anything meaningful from comments here.

HN only works when you have a working assumption that people commenting here are smarter than you. It encourages respect and good faith engagement of content, instead of ad hom, concern trolling, and cargo culting.

It's been years since I've had that mindset when entering any thread above a certain number of comments.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#150

Post by burningChrome »

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

The cure for obesity isn't a pill.

Remember in the 80's and 90's when exercising and being healthy was considered a cool thing? Remember there was a gym on every corner and people were all about looking good and being healthy, eating healthy and living longer?

Then somewhere. . .

- We started normalizing obesity.

- We started this whole "body positivity" trend that celebrating morbidly obese people like Lizzo as positive role models was a good thing?

- We started introducing fat mannequin models in retail stores because being obese shouldn't have a stigma?

Obesity is a problem because we, as a culture have completely normalized obesity. Instead of promoting healthy diets and exercises and saying being obese has consequences like shortening your life and will make you susceptible to various diseases like diabetes and heart disease? All we've done is told people its ok to be obese and eat sugary drinks and over processed foods, because you can just have surgery and that will fix it. Or you can take a pill and that will fix it.

IT WON'T.

IT NEVER WILL.

We've gone down a road that is staggeringly dangerous because we've accepted being morbidly obese as something that's completely normal.

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