Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes • Hacker News Board

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#141

Post by cthalupa » Thu, Oct 24, 2024, 8:12 PM UTC

candiddevmike wrote: post #45

voidfunc wrote: post #19

Earlier quoted context omitted.

Gonna be fun discovering what side effects it causes in 20 years tho.

Seems like you need to increase the usage of it as your body starts adapting to it and the weight loss plateaus. IMO, I think the hype around this drug is a bit much and I expect a significant number of users won't be able to meet or maintain their weight loss goals with it.

I do think the dosing schedule should receive more personalization per-person. The schedule for tirzepatide is 2.5mg a week for the first month, then 5mg, then 7.5, etc.

For me, a month in on 2.5, I was still struggling to force myself to eat enough. Zero need to move up. Some people don't feel anything at all until they're on 7.5mg, though.

There's also a lot of people seeing better success with smaller doses more frequently, too. Instead of moving up to 5mg, I'm doing 2mg every 3-4 days. Loss is still steady and I'm not seeing any indication I'll need to bump up any time soon.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#142

Post by criddell » Thu, Oct 24, 2024, 8:14 PM UTC

Spooky23 wrote: post #55

declan_roberts wrote: post #8

How do you isolate this from the therapeutic benefits of simply losing weight and being skinny?

Omg, you figured it out! Shit. All we need to do is just tell a few million people to lose weight.

I think you misunderstood what they were asking.

If it’s the drug and not the weight loss that lowers Alzheimers risk, then even people who are not overweight might benefit from the drug.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#143

Post by cthalupa » Thu, Oct 24, 2024, 8:22 PM UTC

drowsspa wrote: post #37

qqqult wrote: post #35

Is it the ozempic or just the healthier weight / lower calorie intake?

"Just"?

If it independently helps lower the risk of Alzheimer's even in people that are not diabetic and are of healthy body weight, then it might be worthwhile for those people to take.

If it's purely around the weight loss, etc., then it won't.

I don't think the comment was meant to minimize the impact of losing weight on health.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#144

Post by lawrenceyan » Thu, Oct 24, 2024, 8:29 PM UTC

kelseyfrog wrote: post #137

lawrenceyan wrote: post #57

Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?

Because other interventions have the consequence of actually working. If we compare the efficacy of "telling people to lose weight" vs taking ozempic, there is a stark contrast. Pooled results show that education and counselling[sic] did not significantly reduce weight (SMD –0.73, 95% CI –1.89 to 0.42, n = 3 studies; I 2 = 98%)[1]. The mean change in body weight from baseline to week 68 was −14.9% in the semaglutide…

My bad guys, didn’t mean to be negative in my original post.

Definitely lacking in compassion. Whether it be obesity or anorexia, these are almost always symptoms of something deeper underlying. I shouldn’t be so flippant.

I think I still have to stand by my belief that semaglutide won’t truly solve people’s relationship with food though. That requires going deeper than the temporary solution drugs might provide.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#145

Post by consteval » Thu, Oct 24, 2024, 8:34 PM UTC

VyseofArcadia wrote: post #85

throwaway041207 wrote: post #36

Earlier quoted context omitted.

I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…

> barring any life threatening long term side effects There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. My father was on a long-term maintenance dose of immunosuppressant (I think prednisolone, but I could be misremembering) following his kidney transplant. When it was first prescribed to him, the long term side ef…

We need to keep in mind that this drug address pretty much all of the biggest killers in the West. Not just one, but almost all of them. You name it - heart disease, obesity, alcoholism, smoking.

These things we already know are dangerous, and we also already know they're the most prevalent. We're not treating mesothelioma here.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#146

Post by thefz » Thu, Oct 24, 2024, 8:35 PM UTC

Someone1234 wrote: post #7

benchtobedside wrote: post #2

TL;DR from the article: The study found that patients prescribed semaglutide had a significantly lower risk for Alzheimer’s disease than those who had taken one of the seven other diabetes drugs. The results were consistent across gender, age and weight. The biggest difference was seen when comparing patients who took semaglutide to those who took insulin: Semaglutide patients had a 70% lower risk of Alzheimer’s, the…

With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.

Why would taking a drug you don't need for the rest of your days be a good thing?

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#147

Post by consteval » Thu, Oct 24, 2024, 8:37 PM UTC

BaculumMeumEst wrote: post #92

voidfunc wrote: post #19

Earlier quoted context omitted.

Gonna be fun discovering what side effects it causes in 20 years tho.

- Significantly increased mortality risk - Higher rates of cardiovascular disease - Type 2 diabetes - Sleep apnea and breathing problems - Osteoarthritis due to excess pressure on joints - Multiple types of cancers (colon, breast, endometrial) - Depression and anxiety from social stigma - Reduced mobility and quality of life - Higher medical costs (~$1,429 more annually per person)[1] - Decreased workplace productivi…

Right, this is what people aren't understanding.

We already know the side-effects of the alternative because Western society as a whole has been living them.

It's bad. The obesity epidemic causes pretty much everything bad. This drug doesn't just solve one thing, it solves hundreds or thousands of things all at once.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#148

Post by thefz » Thu, Oct 24, 2024, 8:38 PM UTC

lawrenceyan wrote: post #57

Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?

> Why not just lose weight by eating less? I know that sounds like a dumb question.

Because it requires willpower and discipline, this just a pill/injection doing all the heavy work for you. Hence the success in USA. There are countries where this drug is semi unknown.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#149

Post by thefz » Thu, Oct 24, 2024, 8:40 PM UTC

lazyasciiart wrote: post #64

lawrenceyan wrote: post #57

Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?

This is like asking why ADHD patients don’t just get over it by focusing more.

Nope it's more trying to justify smokers really.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#150

Post by consteval » Thu, Oct 24, 2024, 8:41 PM UTC

sandworm101 wrote: post #42

cthalupa wrote: post #32

Earlier quoted context omitted.

I’ll make my usual response: we know that being obese is basically the worst possible thing you can do to yourself, and the longer you are, the worse it is. The side effects are going to be pretty awful just to negate that, much less all the other things they seem to be good for.

>> being obese is basically the worst possible thing you can do to yourself Lol. I can think of dozens of worse things. Drinking. Cocaine addiction. Meth. Winding up in prison for some reason. Riding a motorcycle without a proper helmet. Getting into a plane flown by Harrison Ford. Even simple unprotected sex can lead to massive medical problems. Ever looked up the average life expectancy of professional athletes, es…

> drinking

GLP-1 solves this too

> Cocaine addiction

GLP-1 solves this

> Meth

GLP-1 solves this

> Prison ... no helmet

Okay, GLP-1 don't solve these but these aren't medical issues. This is just danger

> Even simple unprotected sex can lead to massive medical problems

Mmm... not really. People overblow this. Pretty much all STIs are completely harmless to your health if treated. One shot of penicillin and you're good to go. Your average flu is probably much worse than syphilis or chlamydia. HIV is the "biggest" risk, but HIV doesn't even impact your lifespan anymore.