I broke my Achilles tendon - had to have a FULL reconstruction - they took a tendon that used to help waggle my big toe (the muscle is in my leg) wrapped around my heel and back up my leg and rebuilt my achilles around that - now I have a muscle that used to wiggle my toe than moves my entire foot. How hard was it to relearn? at first I'd try to move my toe and something else would move, it felt weird - but doctor's…
I think if you just exit your subjective perspective, this type of adaptation becomes obvious. What is using a game controller, keyboard + mouse, bicycle handlebars, snowboard, etc but augmentation. Yeah, it's designed to be ergonomic from the outset, but that doesn't change the fact that it is an augment.
Yes.
After 30 years of exclusively "joystick must be inverted Y" I got tired of being able to help other people play a tough spot of a game using their controller, and switched cold turkey. It took 2 - 3 weeks before I didn't randomly aim the wrong way, and 2 months to regain full accuracy.
Similar on the inverted scroll switch that Apple did when they married up scroll on iPad and Magic Trackpad. For several OS versions I stayed with the old way, then too many new users were a direction I couldn't handle, so switched. That switch took maybe 3 days to grok.
One of the weirder tricks you can do is hang upside from jungle gym or over the edge of a top bunk bed and "toss" a ball to your friend, which means you have to throw the ball "down" to them instead of toss it up. You can invert gravity much faster than you'd think!