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Brain waves appear to wash out waste during sleep in mice

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Re: Brain waves appear to wash out waste during sleep in mice

#141

Post by calirepublik »

moffkalast wrote: post #124
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

I wonder if eventually once this is more thoroughly researched there could be a way to induce constant cleaning instead of having to do it while unconscious at night? Or at least reduce the hours required. If we could solve this we could just stay awake perpetually and instantly gain a 30% longer lifespan as it were.

Check this out, I just saw a reference to this recently:

https://www.nia.nih.gov/news/noninvasive-brain-wave-treatmen...

Re: Brain waves appear to wash out waste during sleep in mice

#142

Post by LoganDark »

someplaceguy wrote: post #134
moffkalast wrote: post #124

Earlier quoted context omitted.

I wonder if eventually once this is more thoroughly researched there could be a way to induce constant cleaning instead of having to do it while unconscious at night? Or at least reduce the hours required. If we could solve this we could just stay awake perpetually and instantly gain a 30% longer lifespan as it were.

> I wonder if eventually once this is more thoroughly researched there could be a way to induce constant cleaning instead of having to do it while unconscious at night? Hopefully without having to induce those brainwaves, otherwise you might be able to do it during the day but you wouldn't exactly be conscious. But there's also the question of whether those brainwaves are doing more than just cleaning the brain. I th…

> Hopefully without having to induce those brainwaves, otherwise you might be able to do it during the day but you wouldn't exactly be conscious. But there's also the question of whether those brainwaves are doing more than just cleaning the brain.

...Lucid daydreaming button, anyone? Maybe not lucid if it's the exact same as normal sleep, but I'm sure that if such a thing more exist, you'd be able to adjust exactly how it affects your brain.

Re: Brain waves appear to wash out waste during sleep in mice

#143

Post by dEnigma »

Hrun0 wrote: post #112
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

> which is so newly discovered It says that it was published in 2015, or am I missing something?

> so newly discovered likely you didn’t learn about it in school.

So with the slow pace knowledge makes it into the school curriculum, you likely wouldn't have heard about it in school unless you just left the system a year or two ago (if even then).

Re: Brain waves appear to wash out waste during sleep in mice

#144

Post by thfuran »

Hrun0 wrote: post #112
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

> which is so newly discovered It says that it was published in 2015, or am I missing something?

I'm about the median age in the US and wouldn't expect anyone less than a decade younger than me to have been taught it in school unless they went for a degree in a related field, and possibly not even then. 2015 is after I finished grad school and something like a decade after I'd last taken a class where it might have been taught if it had already been around for enough years to make it into the curriculum.

Re: Brain waves appear to wash out waste during sleep in mice

#145

Post by hx8 »

Aeolun wrote: post #138
_yb2s wrote: post #106

Earlier quoted context omitted.

All NIH funded research is freely open access by law. In this case it seems the authors didn’t pay the (crazy expensive) Nature open access fee. They will have to upload a free PDF to PubMed manually, but have up to a year to do so, and don’t seem to have done it yet.

Is Nature’s open access fee really that crazy? Last time I checked it was a few thousand dollars. And it’s paid once, to make the whole thing open perpetually. It certainly seems better than having the people interested in reading it pay $30-40 each. Of course, this is also based on the few times I’ve heard researchers talk about the ways they could spend their grant money. $2k to Nature sounds like a great deal by c…

Yes, I wouldn't expect someone to pay a few thousand dollars to Nature when PubMed will do the same job for free. I think the role of academic journals is decreasing as open and tech-savvy solutions to information sharing and screening are being deployed.

Re: Brain waves appear to wash out waste during sleep in mice

#147

Post by robg »

moffkalast wrote: post #124
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

I wonder if eventually once this is more thoroughly researched there could be a way to induce constant cleaning instead of having to do it while unconscious at night? Or at least reduce the hours required. If we could solve this we could just stay awake perpetually and instantly gain a 30% longer lifespan as it were.

More efficient sleep is possible with ultrasound. But keep in mind that the glymphatic system seems to expand as other systems contract. The waves are tied to brain activity slowing down, can’t have one without the other. That said, could intersperse active times of the day with naps. But naps alone don’t seem sufficient as good sleep.

Re: Brain waves appear to wash out waste during sleep in mice

#148

Post by robg »

thfuran wrote: post #144
Hrun0 wrote: post #112

Earlier quoted context omitted.

> which is so newly discovered It says that it was published in 2015, or am I missing something?

I'm about the median age in the US and wouldn't expect anyone less than a decade younger than me to have been taught it in school unless they went for a degree in a related field, and possibly not even then. 2015 is after I finished grad school and something like a decade after I'd last taken a class where it might have been taught if it had already been around for enough years to make it into the curriculum.

Great points, I got my Ph.D. in neuroscience 20 years ago. There were disparate theories for why we sleep but no mechanistic description. Most of the research not specifically relevant to my own took 10-20 years to become influential. I’d be surprised if most textbooks for neuroscience-related fields being published today are including the glymphatic system, including psychology / psychiatry and medicine.

Re: Brain waves appear to wash out waste during sleep in mice

#150

Post by telesilla »

d_sem wrote: post #136
Hrun0 wrote: post #112

Earlier quoted context omitted.

> which is so newly discovered It says that it was published in 2015, or am I missing something?

You are missing the context of age demographics. For example: in the United States of America about 63% of the population is over the age of 32 which represents roughly 200 million Americans which graduated Highschool before the year 2010.

And the majority of whoever is teaching university or even high school right now probably graduated themselves before 2015, when the article was published.
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