Windows 10 and 11 have moved away from the registry for applications. It's in C:\Users\ \AppData\Local\ for per-user information I haven't had to go into the registry on Windows 10 or 11 except for enabling beta/early access features.
I have to edit the registry on every Windows install to have: sane multi-monitor config, working macro keys (suppress the "office" key advertisement in my $300 copy of Windows), suppress OneDrive Personal on a machine that syncs to an O365 tenant, have a functional file explorer, and I'm sure a half-dozen other things that don't come to mind immediately. (On top of numerous group policies, which are mostly just sanctioned registry tweaks, along with programs to removed telemetry from 10/11 which I'm confident do plenty of registry tweaking on their own.)
This is all to control first-party functionality; before I've even installed a third party program. So, to the contrary, I can't remember the last time I went into %APPDATA% to tweak something Microsoft-related.