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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

nature.com

141–150 of 170 posts

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#141
post #6

This article is a bit old (like the other comment about missing year tag says). I think there's newer news that AKG, an easy to get and cheap supplement, has anti-aging effects with no known issues. https://www.science.org/content/article/bodybuilding-supplem...

That article says that AKG was 2% of those mice diet, that a lot of supplements if the dosage transpose linearly to humans!

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#142

I’m no fan of death, but death (by natural causes - age, sickness , accident) has been how different generations have gotten rid some of the worst despots.

"Give me liberty AND give me death"?

I'd prefer to solve the despot problem in a way that doesn't involve me getting dead.

Several countries have managed to not have despots for long periods.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#143

Earlier quoted context omitted.

Anti-aging effects in mice*

We've got to be careful or we're going to end up with super-intelligent immortal mice!

I always think of Don Bluth's "The Secret of NIMH" when experimental pharmaceuticals edge those lil' squeakers closer to being an uber-rodent.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#144
post #63

Earlier quoted context omitted.

Would you really want your parents to die, your loved ones, your family, your children, and yourself, all so you could have the satisfaction that at least rich people, and their loved ones, would suffer and die too?

Many people are fundamentally motivated by fairness, and knowing someone else is getting more than they seem to deserve can violate that. Schadenfreude is a thing. Myself, I think that longevity treatments are unlikely to remain unaffordable to the poor for very long after they are invented — even in a cynical world where the rich are greedy enough to try and keep it for themselves, old-age healthcare is really expen…

I suspect that in any society where this exists, the government will end up making it available for everyone... or will be voted out / overthrown for a government that will.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#145
post #85

Earlier quoted context omitted.

> Are you really comparing Theranos to the Nobel prize winning Dr Yamanaka [...] I was responding directly to what you said, this is a strawman. > Of course it's more than just about money [...] This is not the impression I got from your post, because all you talked about was money.

I think both approaches are amazing advancement for humanity, and I wish Greg Fahy would get more funding as well. Before Jeff Bezos came in, the money was really really missing from the longevity field that I have been following for the last 10 years since I've got a serious rare, but not deadly cronic illness. Maybe I've got a bit sad when you refered money as not the most important thing, because Gregory Fahy said…

I agree that having absolutely no money means you cannot do research of any reasonable magnitude. That doesn't mean that money has anything to do with how correct you are :)

> I'm hopeful that both of us (you and me) will be able to use it.

Me too.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#146
post #3

You can do this at home, except for the little inconvenience that growth hormone is a scheduled drug. I wonder what the results would be with just growth hormone. Let's ask Sylvester Stallone[1] who looks great for 75 and got caught trying to get into Australia with illicit Growth Hormone a while ago[2]. [1] https://en.wikipedia.org/wiki/Sylvester_Stallone [2] https://abcnews.go.com/Health/ActiveAging/story?id=317601…

You can significantly boost your growth hormone level by using nicotinic acid (Niacin) and exercise, have a look at figure 3 in this paper https://journals.physiology.org/doi/full/10.1152/japplphysio... .

According to that paper it doesn't have a significant effect on the performance during exercise but it has a large effect on the serum level of GH. However it should be noted that this experiment was conducted on young healthy men and I have no idea if Niacin have the same effect in women or older men.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#147

What are the 3 ingredients? HGH, possibly metformin and what else? The article does not clearly state.

DHEA, Metformin and HGH. My personal preference is to replace Metformin with Berberine since I can get it online or grow it in a greenhouse and it is less likely to induce lactic acidosis. One can fast for 72+ hours to get a massive spike in HGH. I am not a doctor and this is not medical advice. I also consume desiccated Thymus in capsule form following the "like improves like" theories. Here is a video discussing th…

LinuxBender says

>" One can fast for 72+ hours to get a massive spike in HGH."

Relevant URL:

https://hrtguru.com/does-fasting-really-increase-hgh-levels/

referenced articles therein say fasting 48 hours causes a 5-fold increase in HGH, fasting 5 days causes a 10-fold increase, but that 5 days of fasting also makes the cells unable to utilize the extra HGH:

"Despite the fact that fasting may increase your growth hormone, it actually suppresses the anabolic effects of HGH. That’s because fasting lowers the sensitivity of your cells towards HGH, and decreases its main anabolic mediator called Insulin-like growth factor 1 (IGF-1).

Thus you will not experience the benefits of increased HGH on muscle mass, energy levels, etc. ..."

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#148

Earlier quoted context omitted.

DHEA, Metformin and HGH. My personal preference is to replace Metformin with Berberine since I can get it online or grow it in a greenhouse and it is less likely to induce lactic acidosis. One can fast for 72+ hours to get a massive spike in HGH. I am not a doctor and this is not medical advice. I also consume desiccated Thymus in capsule form following the "like improves like" theories. Here is a video discussing th…

LinuxBender says >" One can fast for 72+ hours to get a massive spike in HGH." Relevant URL: https://hrtguru.com/does-fasting-really-increase-hgh-levels/ referenced articles therein say fasting 48 hours causes a 5-fold increase in HGH, fasting 5 days causes a 10-fold increase, but that 5 days of fasting also makes the cells unable to utilize the extra HGH : "Despite the fact that fasting may increase your growth horm…

Agreed. One has to cycle the fasting / exercising / rebuilding. Each trainer and nutritionist appear to have their own preferences to maximize this effect but they also have many confounding treatments and are usually already quite healthy.

I would suggest researching this more on the PubMed nih.gov site as they get into a little more details and usually have decent controls in place in some of the studies. Their search function is awful so I suggest using the following on google to get better results:

    site:nih.gov "search terms"

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#149
post #136
post #73

Earlier quoted context omitted.

And with a single giant ear on their back. Don’t forget the giant ear. (Weirdly, just saw a breathless article talking about how 3D bioprinting obviates the use of rib cartilage that the human-ear-on-a-mouse 25 years ago was also supposed to end).

Not sure why you're skeptical. That ear is physically on the human woman: https://www.nytimes.com/2022/06/02/health/ear-transplant-3d-... Even if it's rejected or otherwise fails later on, that's a long way from just-in-mice breathless talk.

It’s not so much scepticism as cynicism; it works, what I think it doesn’t do is represent a radical (rather merely an incremental) improvement.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#150
post #48

Earlier quoted context omitted.

One thing I rarely see mentioned in regards to living forever is that during a life you will accumulate mental scars. My wife has lost a sister, and she's witnessed a murder. Neither she nor I are the same after those experiences. I don't think we will ever be. If we lived forever I think we would all become more and more anxious and excentric as time progressed and our souls inevitably became more "scarred". Maybe i…

> If we lived forever I think we would all become more and more anxious and excentric as time progressed and our souls inevitably became more "scarred". Not sure, you could apply the same reasoning to people who go thru active wars: the first time they see someone die, they care, but by the time they see hundreds of people dead it does not matter to them anymore.

It matters to them but they tuck it beneath the surface.
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