In C, you can't "just" replace with arbitrary-sized integers. They are fundamentally different memory shapes.
You may not be able to turn enforcement on for all code immediately. There's even the rare bits of code that depend on current overflow behavior. (Due to our human brains and the fact that we can easily name these bits of code, making the cognitively available, people often grotesquely overestimate the amount of code that operates this way. I'm sure it's only a matter of how many zeros belong in the 0.001%.) But we need this support to be available for code to be turn on easily and cheaply.
But what really boggles my mind, again given all the security work we've done, is that the reaction to this remains a combination of silence and "we can't do that!", when it seems to me the reaction ought to be "well duh jerf we all know that already." I don't get this. I don't get this attitude at all. This is a huge source of errors, a good fraction of which are security bugs, and nobody seems to care. Incomprehensible. This is, arguably, the number one thing that could be getting changed right now to fix security issues, and I just get slack-jawed "whaaaa?" in response to the idea.
One hundred plus one hundred is not negative fifty six! Here we are trying to hold together megabytes upon megabytes of security-critical code in a world where 100 + 100 = -56. Is it any wonder that writing any sort of code to maintain security invariants is tough in an environment where 100 + 100 = -56?