Earlier quoted context omitted.
Climate change definitely is the next one. It is most surely happening, and probably faster than we want or expect, but if you listen to scientific consensus (eg. The Intergovernmental Panel on Climate Change report), it is pretty clear that, while serious and troublesome issue, it most definitely is not an existential threat.
Probably not directly. It will cause mass migration and refugee crises as coastal cities and low lying areas slowly flood. That seems inevitable at this point. That could maybe lead to wars, and nuclear war is still an existential threat. If the changes somehow disrupt the ability to support cereal crops in the northern hemisphere (which actually is also the biggest risk from nuclear winter), that could lead to wides…
If we saw significant changes to where is wet and where is dry, we’d be scrambling to catch up and the fallout could be pretty large.