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Oxford University breakthrough on global COVID-19 vaccine
141–150 of 569 posts
Re: Oxford University breakthrough on global COVID-19 vaccine
#142From AstraZeneca: > One dosing regimen (n=2,741) showed vaccine efficacy of 90% when AZD1222 was given as a half dose, followed by a full dose at least one month apart, and another dosing regimen (n=8,895) showed 62% efficacy when given as two full doses at least one month apart. The combined analysis from both dosing regimens (n=11,636) resulted in an average efficacy of 70%. All results were statistically significa…
Is there possible explanation why would first half dose have much better results than full dose?
This vaccine is an inactive host virus whose payload has been replaced by the coronavirus "spike". It has always been a worry that the body will generate immunity to the host virus and thus make the vaccine less effective. That is a likely explanation for the first-full-dose regimen being less effective.
Re: Oxford University breakthrough on global COVID-19 vaccine
#143Earlier quoted context omitted.
Maybe for less developed countries, but i think for major economies, the price difference is insignificant relative to the benefits of any vaccine.
While for now just speculation and without a doubt Machiavellian, it could be that this price difference ends up a significant factor for major economies in their choice for an expensive vaccine. I guess we will know, if/when/once examples of individual discrimination based on what vaccine people received start emerging (hopefully, never). Regretfully, it would be not the first example of major economies using the cu…
What?
I've read this 3 times and can't figure out what you're trying to say.
Are you saying that rich countries are going to intentionally choose more expensive vaccines, with the intention of suppressing the lower classes?
That's so rediculous. In rich countries (other than the usa) the gov pays for these things not the citizens. Even then, the expensive vaccine is only $40, that's within the means of most poor people.
Not to mention that would screw over the rich people who want to benefit from (vaccine induced) heard immunity.
Re: Oxford University breakthrough on global COVID-19 vaccine
#144Earlier quoted context omitted.
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Will you then also pay those who put huge effort and expense in to research that was perhaps necessary but didn't lead anywhere?
Is there somewhere any numbers on how much exactly does it cost? What portion is really "research" and what portion is marketing budget? How much trial phase 1/2/3 cost etc?
Re: Oxford University breakthrough on global COVID-19 vaccine
#145Earlier quoted context omitted.
The disease will 'die out' (in quotes because it will not actually) if there are not enough targets that are susceptible to it. People infected by SARS-Cov2 seem to infect two to six other people [0]. Reduce this number by 90% and we are well below one infection per infected, so it is not sustained. This assumes that everyone would be vaccinated. Currently we are doing something similar: each measure like wearing a m…
Yes. In case of need, the Swiss cheese model: https://mobile.twitter.com/sketchplanator/status/13127289416...
This and "layered defense" are good search terms for this topic in general (not limited to the pandemic).
Re: Oxford University breakthrough on global COVID-19 vaccine
#146Earlier quoted context omitted.
Maybe for less developed countries, but i think for major economies, the price difference is insignificant relative to the benefits of any vaccine.
If they actually get to 90% or more, why would anyone bother with the more expensive and cumbersome vaccines? Except that the EU already signed a deal to buy the vaccines from AstraZeneca, Sanofi and Johnson & Johnson.
Because 95% efficacy is twice as good as 90%. And some people are willing to pay the $30 it costs to be 5% likelihood to have a non-functioning vaccine vs. a 10% likelihood the vaccine you just got won't work on you.
Re: Oxford University breakthrough on global COVID-19 vaccine
#147Earlier quoted context omitted.
The 70% is the combined data, so probably the most reliable estimate. For two high doses, they got 62% effectiveness and for one low and one high dose they got 90%. They don't know why the latter was more effective. 70% is still a great effectiveness rate, specially for a cheaper and easier to distribute vaccine.
The problem with adenovirus vaccines is that body might build immunity against the adenovirus as well. So, you give one jab, adenovirus infects enough cells and creates enough antigens, immune systems notices and does something about it, but it also notices the adenovirus and makes antibodies against that, too. With the second jab those antibodies immediately neutralize the adenovirus so it can't infect enough cells…
> The Russian vaccine avoids it by using two different strains of adenovirus for the two jabs
That would complicate manufacturing, logistics and distribution somewhat right?
Re: Oxford University breakthrough on global COVID-19 vaccine
#148Earlier quoted context omitted.
Is there possible explanation why would first half dose have much better results than full dose?
This vaccine is an inactive host virus whose payload has been replaced by the coronavirus "spike". It has always been a worry that the body will generate immunity to the host virus and thus make the vaccine less effective. That is a likely explanation for the first-full-dose regimen being less effective.
Shouldn't it warrant a research if even smaller dose has even higher efficiency?
Re: Oxford University breakthrough on global COVID-19 vaccine
#149Earlier quoted context omitted.
>At $3 to $4, many countries will jump on board ASAP and stay away from the expensive vaccines from Pfizer and Moderna. The price difference will likely remain substantial, but in case anyone is unaware, the difference is currently greater due to AstraZeneca pledging to the sell the vaccine at cost "during the pandemic", while Pfizer and Moderna have indicated that they fully intend to profit. [1] Once AstraZeneca de…
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I agree that in cases of overwhelming national interests patents and licensing should be ignored if they stand in the way.
But: this is not a medicine made of a molecule that can be synthesised by the chemical industry. Such a vaccine requires input from the creator and then specialist equipment to manufacture. Poor countries don't have the infrastructure to manufacture and the creator labs are not going to tell you how to produce the vaccine just because you ask them.
In any case, governments should pressure labs to enforce an low prove.
Re: Oxford University breakthrough on global COVID-19 vaccine
#150Earlier quoted context omitted.
"gild the lily" = try to improve what is already beautiful or excellent.
70% efficacy at 2c-8c storage for $4 is indeed excellent but many comments here go to "but modena is 95% efficacy whyyyy" and "they're underselling it"
They also tried 2 different dose regimens, one of which had 90% efficacy. The 70% figure is the weighted mean of the two I think.