Live data from Hacker News

Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

who.int

141–150 of 400 posts

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#141
post #63

Earlier quoted context omitted.

I don't think anybody's denying it exists. What hasn't been shown is if long-term consequences are more prevalant with covid than with other viral lung infections.

Studies on long-term consequences of a virus that has been around for <1 year?

You can check how much people get better in a few months and extrapolate.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#142
post #129

Earlier quoted context omitted.

No, IFR is the infection fatality rate. It's the number of fatalities divided by the number of infections. If you reduce the infection rate, the proportion of those infections that results in death will not change. This of course doesn't apply if healthcare systems are overwhelmed, but that's not what we're talking about here.

We don't test for who has flu.

That does not affect the IFR, it just make it harder to measure.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#143

Earlier quoted context omitted.

> less than double your chances of dying in a year. The way this is phrased makes it sound like it's not a big deal. Doubling every individual's chance of dying within an entire generation is not something we should say lightly. Imagine if the base fatality rate was 50% rather than .5%.

Double 0.5% is 1%. Where'd you get 50%?

I believe the parent was making a rhetorical point: if your base fatality rate were 50%, then doubling it would mean you’d be guaranteed to die. Therefore, saying something “only” doubles your risk of death can understate the impact of what that doubling means in practice.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#144

For comparison, from what I've read the typical annual influenza fatality rate is around 0.1% (don't know what the under-70 rate would be). So, this puts covid-19 solidly in the uncanny valley of viral mortality rates; not low enough to be "just like a flu", not high enough to justify shutting down the world. No wonder opinions on it are so divided.

Daily reminder: new respitory diseases come and go, nobody usually cares. What makes Covid different and what caused the shutdowns was when Lombardy alone had 450 deaths a day. No regular influenza could do that. It's not as if we decided out of thin air the virus was dangerous.

"No regular influenza could do that."

Sure it could. The whole point of the IFR calculation is that it gives you an average perspective on how fatal a disease is, relative to other diseases. It's not an absolute maximum fatality rate, for every circumstance.

Put a strain of "normal" flu in a vulnerable population with no pre-existing immunity, and it would do a lot of damage. But if you don't count all the other people who had it without symptoms, then you get a misleading picture.

Also, of course, you have to realize that the population of "Lombardy" (~10M) is a bit larger than the population of New York City (~8M), where we see 100-300 deaths per day as a baseline mortality rate:

https://www.baruch.cuny.edu/nycdata/population-geography/pop...

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#145
post #103

Earlier quoted context omitted.

>This isn't good news, really, not for middle-aged-adults anyway. Or for anybody who knows middle aged and older people, especially if you spend time with them. I am honestly more concerned about killing my parents than dying myself of covid-19. This is why I skipped my mom's birthday for example, because I had pretty mild cold-like symptoms... or maybe mild covid-19.

That was always a risk even before COVID-19. Regular seasonal influenza can be deadly, especially to the elderly. Patients can transmit it to others when they are asymptomatic or presymptomatic. COVID-19 has a longer incubation period and a significantly higher fatality rate but the same fundamentals still apply. Any of us could have inadvertently killed someone by giving them the flu without even realizing it.

Flu is about 1/10 as deadly as coronavirus. And there’s a vaccine.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#146
post #129

Earlier quoted context omitted.

We don't test for who has flu.

That does not affect the IFR, it just make it harder to measure.

You don't know the number of people who die who were infected if you didn't test them. I think your argument is only valid when the death rate is the same amongst tested and untested people.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#147
post #103

Earlier quoted context omitted.

>This isn't good news, really, not for middle-aged-adults anyway. Or for anybody who knows middle aged and older people, especially if you spend time with them. I am honestly more concerned about killing my parents than dying myself of covid-19. This is why I skipped my mom's birthday for example, because I had pretty mild cold-like symptoms... or maybe mild covid-19.

That was always a risk even before COVID-19. Regular seasonal influenza can be deadly, especially to the elderly. Patients can transmit it to others when they are asymptomatic or presymptomatic. COVID-19 has a longer incubation period and a significantly higher fatality rate but the same fundamentals still apply. Any of us could have inadvertently killed someone by giving them the flu without even realizing it.

This is all true, but COVID hysteria has taken hold across the entire world, and HN is no exception unfortunately.

You are being reflexively down voted because people view any comparison to Influenza as illegitimate, not realizing that you are making a broader point about risk management and attribution of blame for infection as opposed to saying that SARS-2 and Influenza are literally the same viruses.

Personally I find it fascinating that I was never told it was my fault if I gave someone the flu in the course of both of us living our normal lives, but if I go to a grocery store and an elderly person does too and they get COVID-19 from me (imagine in this hypothetical there is no doubt that I gave them the virus) then somehow it’s my fault and I’m guilty of any harm that befalls then.

Incredibly dangerous precedent. I hope people see where it leads. And I hope they learn from the history of public health, such as when “public health officials” used to shut down gay bars “for the greater good”.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#148
post #131
post #120

Earlier quoted context omitted.

https://www.medrxiv.org/content/10.1101/2020.10.14.20212555v...

That's interesting, thanks. First study I've seen with more than a handful of participants, doing something other than self-reporting of symptoms. That said, it's notable that: * They don't have a control group (makes it impossible to know what the baseline rate of these symptoms is in the population). * They don't measure the various criteria for "organ impairment" before the participants caught covid (makes it impo…

There are beginning to be data on this available around well defined, young, and ultra healthy groups such as athletic leagues. Look within a given league at these long term effects / organ damage / health problems among those who recovered to rule out a lot of the self-selection or other variables.

To some of your other points, the high end leagues are quite well medically documented, and the individuals are quite healthy.

That said, it also appears for some individuals, initial “long term” damage (ongoing heart or liver problems three months after recovery) may be less or gone some six months in.

Seems answers are as yet by and large unresolved. In situations where one does not yet know the actual risk, one may prefer an abundance of caution over unknown “calculated” risk given the long tail of possible effects.

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#149

Earlier quoted context omitted.

It's generally illegal, outside of narrow circumstances, to fire guns in populated areas largely because stray bullets will kill people. Stray respiratory droplets exhaled by people infected with SARS-CoV-2 will also kill people. Presumably you're OK with rules that prevent people from firing guns in public. Why are you not OK with rules that are intended to reduce the risk of people unnecessarily spreading fatal inf…

The idea of a "causal nexus" is not accepted in any law system (natural or positive). The fact something can happen due to your actions can't be used as an ethical argument to limit your freedom of action. From the perspective of individual freedoms the ban of guns is unacceptable under the pretense they might end up harming others by chance; if that's the case, the police and the military themselves shouldn't have g…

Yes, this is why there are so many shooting deaths in the UK, because they have strict gun control laws /s. I see this argument all the time from otherwise intelligent people and its amazing to me. Why bother making murder illegal? It will only stop law abiding people from killing anyone, and criminals will still murder people! Yes I know this is a reducto fallacy, however the argument you're making is fundamentally that no laws should ever be created for anything since some people are going to end up breaking them. The argument I hear commonly sited is that guns are easy to get in Chicago, or Mexico, which both have very strict gun restrictions. Although this is true, it fails to take into account that the guns are so easy to get because of the incredible lax rules in the nearby suburbs/across the boarder. The reason guns are being used to kill people in Mexico is because how stupidly easy it is to get them in Texas.

The police in the United Kingdom DONT HAVE GUNS, because the general populace dont have them and the number of per capita gun deaths is [1] https://en.wikipedia.org/wiki/List_of_countries_by_firearm-r...

Re: Infection fatality rate of Covid-19 inferred from seroprevalence data [pdf]

#150
post #103

Earlier quoted context omitted.

That was always a risk even before COVID-19. Regular seasonal influenza can be deadly, especially to the elderly. Patients can transmit it to others when they are asymptomatic or presymptomatic. COVID-19 has a longer incubation period and a significantly higher fatality rate but the same fundamentals still apply. Any of us could have inadvertently killed someone by giving them the flu without even realizing it.

This is all true, but COVID hysteria has taken hold across the entire world, and HN is no exception unfortunately. You are being reflexively down voted because people view any comparison to Influenza as illegitimate, not realizing that you are making a broader point about risk management and attribution of blame for infection as opposed to saying that SARS-2 and Influenza are literally the same viruses. Personally I…

I don't see the point. There are rules now, so not following them would indeed make it your fault if someone gets sick because of your actions that were not in accordance with the rules.
Post reply on HN