I take a 60K softgel monthly, and I believe it has vitamin D in an oil carrier.
50k is what I’ve seen some friends get for extremely low vitamin D, and on a similar time interval to your prescription. But you don’t want to be taking that every day. Let alone two to three of them.
I agree that this isn't something you'd want to take multiple times a day, for an extended period of time. that said, from the original case study, it sounds like the woman was attempting the Coimbra Protocol. Whether it works or not is another question. It also requires a very low calcium diet and close monitoring of calcium & parathyroid levels - which I'm guessing the lady did not do.
I see Vitamin D toxicity at MUCH lower doses than in this case report. Here is my description of one patient: https://www.devaboone.com/post/vitamin-d-part-2-shannon-s-st... Most of the patients I see with vitamin D toxicity are on 5000 units daily or more. And it can take a while (years) for toxicity to occur. Vitamin D builds up during that time since it is fat-soluble. If you want to take Vitamin D over a long per…
Thanks for sharing this write-up. I’m also concerned with the unbounded enthusiasm for Vitamin D supplementation in the wake of all the COVID news. The two most common mistakes I see online are: 1) Not understanding the long elimination times of these vitamins. When overdose can take months or years to appear due to gradual accumulation, it becomes difficult to associate health problems with slowly increasing vitamin…
There is another one: regulation of vitamin D occurs before synthesis in the body.
Ready vitmain D from food/supplements can't be regulated by the body and all excess vitamin D will have its full effect.
Something missing is how fast did the patient ramp up to that dosage. If you start at a very high dosage, you will mobilize all the stored calcium in the gut and vascular system. It has to go somewhere. As some who is currently at 52k UI's per day, I can say that if I started at that level I would have damaged myself in many ways, not just kidneys. I started at 2k per fatty meal/snack and worked my way up over a few years. The purpose has been to de-calcify my vascular system and gut. I can actually tell when I am near the limit as it induces pain. I back down a few thousand IU's for a couple weeks, then keep working back up. When I first started, I could not exceed 4k per meal without getting blurry vision. Now that happens around 54-56k. I probably will not go much higher. I do not suggest doing this unless you have a good reason to do so. If you must do this, then be sure to include K2 MK-7 and magnesium for each dosage to bind and transport some of the calcium to the bone. I am not a doctor and this is not medical advise, not to mention, only a small percentage of functional medicine doctors use this method of de-calcification. My BP has dropped over 20 points, so I am making some progress. For people just wanting enough 25-hydroxy to fuel their immune system, 2x the RDA is probably fine assuming normal renal health. BTW, measuring 25-hydroxy has little value unless you know your kidney health, as that is the not the final stage of the hormone.
> So aside from testing your blood serum levels you should consider a genetic test to see how well you absorb vitamin d. You may benefit from above average dosage (consult your dr. Ymmv) The only thing that matters is the serum level. Testing your blood levels is like closing the feedback loop. Levels too low? Increase dose. Too high? Back off. Genetic testing isn’t necessary or even really helpful. Just get the basi…
I hate everything about this comment. first of all, low/high levels have a cause. if it's nutrition, yeah, you're right, just measure and correct. but you come to the conclusion that's nutrition with zero evidence supporting it, and that's annoying as hell, because it's basically shunning the door for people with real conditions that could live 10x times better if only someone would have used a more rigorous method o…
You’ve misunderstood.
Measuring serum levels is sufficient to detect and work around genetic absorption defects. No one needs to get separate genetic testing if their serum levels are within range.
For those interested in Vitamin D and Covid, here is a summary of the research so far: https://www.devaboone.com/post/vitamin-d-and-covid
TLDR of this referenced article: In each and every scenario and study that is examined there is a general consensus that Vitamin D deficiency may be correlated to increased susceptibility or severity of COVID-19. The final conclusion is a word of caution that this news may cause some people to load up on Vitamin D at dangerous levels. However it also states that taking a small daily dose IS actually a good idea during Covid. The dose recommended in the article for pretty much anyone is 1000 IU during Covid.
If you do strenuous workouts frequently then this helps you recover faster and workout longer. If you are just couch potato then it’s actually detrimental and you can develop all sorts of problems including peripheral neuropathy.
Strenuous workouts don't cause chronic deficiency and don't eliminate chronic overdosing.
I used to run ultra marathons, when you push your body to the limit like this, you do run into limits and deficiencies, not chronically but during hours of running and this extra overdosing does help the body function better
I had a mini-episode of this earlier this year. Reposting as a warning for people: I had mild Vitamin D deficiency which was diagnosed by a doctor many years ago. I was given Vitamin D supplements, which I stocked up on more than usual recently due to my staying in all day due to WFH and not getting any sunlight. I used to take 50mcg of D3 1-2x a week and I upped that (without consulting a doctor) to 5x a week. Withi…
For another anecdote, I regularly get bottles of gummies which are 1500IU each (you're talking about 2000IU for reference), eating 3-6 of them a day, all through seasons which aren't summer. I've never traced negative health effects to this. Not being a doctor, I can't give advice, but my doctor thinks this is safe, and in fact, a good idea.
Fun, but that's a lot of sugar and tooth decay when a pill would do.
Strenuous workouts don't cause chronic deficiency and don't eliminate chronic overdosing.
I used to run ultra marathons, when you push your body to the limit like this, you do run into limits and deficiencies, not chronically but during hours of running and this extra overdosing does help the body function better
Ultra-marathons aren't "strenuous exercise" by any reasonable definition, they're much more extreme. For most people "strenuous" involves high heart rates for a half hour or so.
Yea I thought that was common knowledge since at least when Paracelsus said it 500 years ago: "All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison."
That platitude is not that helpful. What would Paracelsus' advice be on the toxic dose of vitamin B12?
Not really sure your point. Are you saying that there is no upper safe limit for B12 for all people?
>...Case details: A young woman was treated with multiple daily doses of 1 mg of cyanocobalamin for severe pernicious anemia. After a total dose of 12 mg, she developed acne, palpitations, anxiety, akathisia, facial ruddiness, headache, and insomnia. She improved two weeks after stopping the drug. There were no sequelae nor complications.Discussion: Although these symptoms of cobalamin toxicity were unexpected and unusual, the case reminds us that the administration of any drug is not entirely safe.