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YC Bio

blog.ycombinator.com

141–150 of 155 posts

Re: YC Bio

#141
post #13

Biology and AI could possibly be the next coal face

Are you saying that it is going to make as much revenue as coal? That would make sense, but the amount of jobs created is going to be lower I would guess.

Coal face is an metaphor :) It means that labour in this discipline will produce many new products and results https://en.wiktionary.org/wiki/at_the_coal_face

Re: YC Bio

#142

I am cheering for you guys, but.... I fear YC is moving way out of its center of competence. Startup mantras like "build something people want" and "move fast and break things" are probably wildly inappropriate for the biotech world. Even the setup of the the YC course, where you hack intensely for three months and then present something cool at Demo Day, seems totally misconfigured for doing bio research.

Yes, life sciences is very different. We've been funding life sciences companies for several years now, so we've learned how to adapt our advice. We've also made tweaks to the YC batch cycle to fit companies with longer development cycles.

It's still not perfect, though, so the things we're trying in this experiment, like providing lab space for companies, are the next step.

Re: YC Bio

#144

Timing is perfect on this. We are fortunate enough to be witnessing Year One in the Age of Crispr ;) For those brainstorming startup ideas some relatively recently funded companies include: eGenesis - Dr. George Church's company that uses edited porcine stem lines for human xenotransplantation Twist Bio - synthetic bio for applications ranging from novel materials to data storage Denali - focus on age related neurode…

And here’s my take on how this will play out... Tech investors are almost totally unequiped to do the necessary DD. They either therefore go for plays that are easy to understand, largely computational exercises or in the rare cases they do go for something higher risk, they back something crazy (e.g. Theranos) because they don’t do good DD. Getting an “expert” to vet the play rarely works. Because tech VCs don’t kno…

I totally agree. Lots of people think they are experts (or have understanding) in health care or biology but for this you need to be an expert in health care development which is only partially related. The major difference is that in tech, the question most of the time is whether a product makes sense, not whether the proposed things work. In biology, its pretty much the other way around.

Re: YC Bio

#145

Earlier quoted context omitted.

From my perspective it’s somewhat the opposite. I’ve tried to be calm and measured and friendly while you (a) assumed I was trying to attack you (I have no idea why), (b) assumed I have a strongly held opposition to the general idea of kids staying at home (I am not planning to keep my kids at home – I would rather have them out exploring the city – but am not going to judge other parents for whatever beliefs/practic…

You started with: kids who live in a hermetically sealed bubble, never share toys, and only ever interact with a couple of adults. You now assume that I am suggesting kids never go to a park or grocery store etc. I see no means to find common ground here. Your assumptions about me are so extreme that it is impossible to engage you effectively. And there is zero reason for you to assume I am talking about such an extr…

I assumed none of those things. You are reading much more into my comments than is written there. I don’t really know why, but I don’t think I have time to unpack what went wrong with this communication.

If you made fewer assumptions and parsed other people’s comments more carefully, critically, and charitably, not looking for personal attacks under every rock, you might find fewer discussions offensive. YMMV.

Happy new year. I hope all is well with you and your family.

Re: YC Bio

#146

Earlier quoted context omitted.

You started with: kids who live in a hermetically sealed bubble, never share toys, and only ever interact with a couple of adults. You now assume that I am suggesting kids never go to a park or grocery store etc. I see no means to find common ground here. Your assumptions about me are so extreme that it is impossible to engage you effectively. And there is zero reason for you to assume I am talking about such an extr…

I assumed none of those things. You are reading much more into my comments than is written there. I don’t really know why, but I don’t think I have time to unpack what went wrong with this communication. If you made fewer assumptions and parsed other people’s comments more carefully, critically, and charitably, not looking for personal attacks under every rock, you might find fewer discussions offensive. YMMV. Happy…

I didn't say I was offended. I consistently said this is simply not constructive. You are putting words in my mouth.

Re: YC Bio

#147
I wish I could somehow make sense of my both biological and software proficiencies, and I try to follow what's happening in the Biotech world, but nowhere do I feel like an ideal fit. So I enjoy doing both separately for the moment !

Re: YC Bio

#148
post #35

Earlier quoted context omitted.

Every disease is a different beast, and biology is very hard to tame. We've thrown probably trillions of dollars at cancer over the past few decades, and only in the past few years, with immuno-oncology, has there been any real hope of progress toward broad cures (there was a heady moment after Gleevec, too, but that turned out to be the exception rather than the rule). There was just a huge wave of Alzheimer's treat…

My father had Alzheimer's. He lived another 3 years after doctors announced he had six months left because my mom was a devoted wife who quit her job to take care of him. He also survived colon cancer in his late 60s for the same reason and I flew out and took care of my sister after her first mastectomy with her first round of cancer. The doctors attributed my father's survival after they wrote him off for dead to m…

Getting familiar food regularly, having someone who genuinely cares about you, and having control of your environment are all medically recognized (with peer reviewed research to support it) methods to reduce stress and stress hormones.

And stress is a significant factor in mortality rates. Its a major predictor for long life and health. It impacts metabolism, pain reception and recovery rates, and reduced stress in surgical patients is a universal good regardless of diagnosis. Its not a cure. It won't stop an infection or cure cancer, but the benefits are very real and has a good bit of research behind it.

Re: YC Bio

#149

Earlier quoted context omitted.

The enormous degree to which I am repeatedly invalidated is apparently lost on you. If I were being taken at all seriously then people would be asking me how on earth I am doing this, not being faux respectful on a foundation of "obviously she is full of crap and knows nothing." Doctors never have any interest whatsoever in how I am getting healthier. They merely assure me it has zero relevance to anyone else on the…

> If I were being taken at all seriously then people would be asking me how on earth I am doing this https://www.theravive.com/therapedia/narcissistic-personalit...

What’s wrong with you

Re: YC Bio

#150
post #34

Awesome! We've been supporting start up bio companies by offering them a fair pricing on equipment, supplies and chemicals. I think we've sold to every YC bio company except Ginkgo (doh!). There's a huge problem in non-transparent pricing for products. For those outside the industry it's like buying used cars, dealing with sales reps and everything is a quote. Researchers are at a huge informational disadvantage when…

Is there are reason you only accept university email addresses? Seems strange if you are targeting biotech companies.
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