Earlier quoted context omitted.
I think the du case was an outlier. Normal workloads shouldn't be so heavily affected. I am expecting a few percent loss on most programs though. It's basically a larger penalty for making a syscall, which was already a fairly slow operation so performance minded people avoid them in tight loops. It will be bad for people who need to do lots of fast I/O I suspect.
Sounds like servers handling lots of small UDP packets would be hit pretty hard.
DPDK for 10-100 Gbps networking: https://dpdk.org/
SPDK for NVMe storage: http://www.spdk.io/
The queuing and balancing stuff the kernel does makes sense for spinning rust harddisks and residential networking, but when the underlying hardware is so fast that nothing is ever queued, really what are you doing. At 100 Gbps line speed, a 1518 byte packet takes all of ~ 120ns to transmit, or about 360 clock cycles for a 3 GHz processor.