If malware can exploit a 0-day, 100-day, 1000-day security hole in a corporate network of 2000 machines, its too easy for that malware to share itself across the network and send emails attachments to AllUsers (every single company I've worked for still allow Everyone to send anything to Everyone).
Microsoft's next XP patch should be to remove SMB functionality or just outright disable it (and probably remove IE and other nonsense installed by default too).
And when Windows 7 expires the final patch should be a severe lock down too..