From another thread (still relevant I think):
uBlock, NoScript and RequestPolicy are my tools to control the content my web browser displays. My general rule is that I'll only disable ad blocking on a few trusted sites and never on a site that uses a third-party advertising network.
Most advertising networks have intrusive or annoying ads that actually block my ability to read a site by using pop-overs if my mouse cursor accidentally touches a keyword, divs that obscure content until I've paid sufficient attention to locate and click the "X", auto-playing sounds/videos, etc. If the UX wasn't bad enough, these third-party networks also present a security risk and have been used in the past as delivery vehicles for malware.
In the end if a web site relies solely on intrusive advertising for support and they plead with me to disable adblocking, I'll most likely choose to stop reading/participating on the website rather than make an exception for them.
I really wish the ability to make micropayments to publishers was a thing.