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Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

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Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#131

Post by Jean-Philipe »

tgsovlerkhgsel wrote: post #10

The paper claims that 1/5 of people experience Long COVID after an infection. Given that approximately everyone has caught COVID by now, this does not track with how rarely I've heard of people with it. Wikipedia lists much lower numbers on https://en.wikipedia.org/wiki/Long_COVID (6–7% in adults, ~1% in children, less after vaccination.) and seems to use a more liberal definition than this paper, as it mentions "Mos…

Not sure it's relevant at all, but a therapist who's working with kids in a large clinic in Berlin told me that anorexia cases in kids have doubled since COVID. He said they don't have the infrastructure to treat all those kids. It's pretty dramatic. That being said, I wouldn't be surprised if a large portion of those cases were really caused by long COVID.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#132

Post by anon84873628 »

Tarsul wrote: post #6

This is (probably) not a Long Covid story but I found that bloodletting (for which I even received money!) gave me back the energy that I was missing for the last few years (e.g. it was impossible to build stamina). I also read about a study about the positive effects of bloodletting[1] that somehow is not all the rage in mainstream news, which I find perplexing. If it might be so easy to improve your health (for som…

The modern version of this is called Therapeutic Plasma Exchange (TPE) or Plasmapheresis and it is used to treat a variety of conditions including cancer and autoimmune:

https://my.clevelandclinic.org/health/treatments/24197-plasm...

There are also claims that it improves dementia / Alzheimer's symptoms and popular "longevity biomarkers".

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#133

Post by Llamamoe »

swed420 wrote: post #118
Llamamoe wrote: post #103

Earlier quoted context omitted.

There's more to air quality than HEPA filters. In-line far UV sterilisation, ventilation to reduce rebreathing and CO2 levels, and HEPA might not be enough as a single-building intervention, but it would almost definitely change disease spread dynamics if deployed world/nation wide.

> There's more to air quality than HEPA filters. Agreed. In fact, even before COVID this was long overdue to be addressed in classrooms etc: > ventilation to reduce rebreathing and CO2 levels Unfortunately since that hasn't happened yet, methods like: > In-line far UV sterilisation > HEPA are not effective. It isn't that they don't kill/stop the virus. The problem traces back to the inadequate forced air exchange and…

> Otherwise, what's the benefit seen if you delay an average (but inevitable) infection from occurring by X days? There basically is none.

It reduces the R0 factor, which reduces the amount of people that need to be resistant for herd immunity to take place, and which makes it easier for other measures to bring it down further, potentially below 1 where the disease dies out instead of continuing to spread.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#134

Post by longcovidthrowa »

ck2 wrote: post #127
longcovidthrowa wrote: post #63

Earlier quoted context omitted.

I won't make a claim to the accuracy of the numbers, but I can offer an example of how long COVID can be undercounted. My daughter was a competitive long distance runner. Months after recovering from the acute symptoms of COVID, her performance numbers were still about 10% down and no amount of training would allow her to reach her previous level of performance. After many visits to doctors and specialists, she was e…

I was a highly trained endurance athlete my entire life and covid/long-covid absolutely destroyed all of that, permanently After 5 years I would happily trade only a 10% performance loss for the days and nights full of nerve damage pain (neuropathy)and what seems to be 30% performance loss BTW very relevant to your daughter's story: the first year of long-covid I was absolutely certain I had permanent lung damage and…

Thank you for the information, and I'm sorry to hear about your struggles.

> The first is that it might not be permanent alveoli damage (which do not regenerate in humans) but rather obstruction from a "hydrogel" that forms during active covid and takes many many months if not years to dissipate entirely

I didn't go into too much detail in my original post, but we think this is likely what happened to my daughter. Post-COVID, she could still go for long durations at 80% but when she pushed her limits, she would hit a wall and start to experience asthma like symptoms along with the feeling like she had mucous in her lungs that she couldn't get out. It took close to 2 years for her to stop experiencing those symptoms, at which point her competitive running peers had passed her by. She's happy to be able to enjoy running again but she did lose out on the competition part.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#135

Post by nradov »

onlypassingthru wrote: post #117
withinboredom wrote: post #110

Earlier quoted context omitted.

If death were so guaranteed from injuries, I doubt we’d have survived as a species.

Before the discovery of antibiotics, chopping it off was the usual standard of care for serious infections.

It's very rare for a minor injury to become seriously infected to the extent that the patient's immune system can't fight it off. Even before the discovery of antibiotics, amputation was typically only used as a salvage therapy in cases of gangrene. They didn't reach for the bone saw just because you had a serious infection.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#136

Post by swed420 »

Llamamoe wrote: post #133
swed420 wrote: post #118

Earlier quoted context omitted.

> There's more to air quality than HEPA filters. Agreed. In fact, even before COVID this was long overdue to be addressed in classrooms etc: > ventilation to reduce rebreathing and CO2 levels Unfortunately since that hasn't happened yet, methods like: > In-line far UV sterilisation > HEPA are not effective. It isn't that they don't kill/stop the virus. The problem traces back to the inadequate forced air exchange and…

> Otherwise, what's the benefit seen if you delay an average (but inevitable) infection from occurring by X days? There basically is none. It reduces the R0 factor, which reduces the amount of people that need to be resistant for herd immunity to take place, and which makes it easier for other measures to bring it down further, potentially below 1 where the disease dies out instead of continuing to spread.

> It reduces the R0 factor

The results of the study suggest it doesn't, as measured by outcomes:

> While we did not find an association between HEPA purifier use and high overall viral exposure, the intervention was associated with a 32.8% reduction in viral diversity. However, the clinical significance of these changes is not clear given that we did not find an association between viral diversity and school absenteeism.

Point being, it only takes a very small dose of a aerosol borne virus to keep it in circulation. Breaking this chain requires extreme measures. Not impossible to achieve, but not trivial, either. Considering the widespread damage that long COVID is causing, I sincerely hope we find a way.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#137

Post by BobbyTables2 »

throAway007 wrote: post #121
Retric wrote: post #104

Earlier quoted context omitted.

> you'd have to throw out the slower finishers who maybe weren't trying hard. But if there's a significant correlation then it ought to show up. Poor performers and no shows are exactly the population you’re looking for. To be clear the argument isn’t about a 10% decline across the board among people with long COVID as there’s non cardio pulmonary symptoms like brain fog, loss of smell, and difficulty sleeping. If 80…

This makes sense. I would've been marked as a "no show" because I had to rescind a job offer because of long COVID which lasted a year. From the government's point of view I was just an unremarkable figure prolonging my bout of unemployment when in fact I had a great job offer lined up that went to shit because I got COVID while on my little bit of celebratory vacation The PVCs, adrenaline dumps, sleeping problems an…

Did any treatments help? Or just took a long time to settle down?

When you mention “adrenaline” was this somehow tested or just a frequent feeling of being stressed when you had no reason for such?

I find finding the right type of specialist isn’t always straightforward and even when one does, about 80% of the time they aren’t interested in diagnosing anything not blatantly obvious…

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#138

Post by TaupeRanger »

abracadaniel wrote: post #124
TaupeRanger wrote: post #111

Earlier quoted context omitted.

The post implied that doing a “blood oil change” was potentially a good thing. My point is, we don’t know either way, because a study hasn’t looked at that question for health outcomes. It could be doing more harm than good, the parent commenter doesn’t know.

They linked a study in their comment.

The study doesn't show that donation is a good thing. Showing a miniscule reduction in blood markers is not the relevant variable - what you'd actually care about is: do I liver a longer or better life because of this intervention? There simply isn't any evidence that a tiny reduction in PFAS from blood donation results in any improvement in any clinical outcomes. Because we don't know either way, it's also possible that there would be harms from this - as blood donation is not entirely risk free, exposing people to syncope while driving after giving blood, skin complications like infections, or other rare issues we don't even know about.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#139

Post by Arete314159 »

tgsovlerkhgsel wrote: post #10

The paper claims that 1/5 of people experience Long COVID after an infection. Given that approximately everyone has caught COVID by now, this does not track with how rarely I've heard of people with it. Wikipedia lists much lower numbers on https://en.wikipedia.org/wiki/Long_COVID (6–7% in adults, ~1% in children, less after vaccination.) and seems to use a more liberal definition than this paper, as it mentions "Mos…

Long Covid is a spectrum. It's everything from silent damage to severe functional impairment. Each subsequent infection makes noticeable damage more likely.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#140

Post by Arete314159 »

swed420 wrote: post #80
Llamamoe wrote: post #40

Earlier quoted context omitted.

It takes very severe disability for it not to be brushed off as depression, anxiety, burnout, or blamed on lifestyle. Additionally, a lot of those numbers are based on earlier strains of COVID, which were much more severe. I suspect the 1/5 figure is largely true for "has some degree of cardiovascular damage and worsened general health after COVID", but the number of people actually disabled by the condition is much…

> Additionally, a lot of those numbers are based on earlier strains of COVID, which were much more severe. Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era https://www.thelancet.com/journals/laninf/article/PIIS1473-3... (The same omicron era the media originally claimed was "not as bad as previous variants." Perhaps not in the acute phase, but as we've seen, that's t…

It's a layered approach. There's not one silver bullet. But sending kids to school without clean air upgrades is criminal.
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