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GLP-1 drugs: An economic disruptor? (2024)

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131–140 of 553 posts

Re: GLP-1 drugs: An economic disruptor? (2024)

#131

Earlier quoted context omitted.

The population of a specific Google office could be two std deviations from the mean. My office area, SoHo NYC, has a dramatically lower obesity rate than the USA average. Maybe 10-20% of the population is overweight, let alone obese, and it’s mostly the service workers.

But 1 of 1000s? That sounds like it's made up, or a very, very, very fitness-focused company.

I edited my response. I'm from Canada, but we also have a 26% obesity stats.

Re: GLP-1 drugs: An economic disruptor? (2024)

#132
post #77

Earlier quoted context omitted.

You can get wegovy generic for $299/mo and Zepbound generic for $399/mo currently through telemedicine via compounding pharmacies, without insurance.

Maybe they are in Canada. Name brand Ozempic is $230 CAD or $160 from Costco up here

[flagged]

Re: GLP-1 drugs: An economic disruptor? (2024)

#133
post #2

One person's results is not everyone's results. To say that this is hyperbolic would be the understatement of the millennium.

What does this even mean? The results of GLP-1 meds are well studied and widely understood to be game changing and likely revolutionary. The other claims might be hyperbolic but results of the medication on individuals is not really a question at this point.

I think some skepticism is warranted. If this is a medication that most of us can be on and it comes with positive health benefits, that would mean that humans as a species have lower than optimal GLP-1 levels. I guess it’s possible that our bodies are wired for a world that is unlike today’s and that these drugs correct for that. But drugs that doesn’t come with side effects. It also wouldn’t be the first time that a drug company manages to convince the medical community to think a drug is healthier than it really is (OxyContin).

Re: GLP-1 drugs: An economic disruptor? (2024)

#135
post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I've heard similar accounts and it sounds pretty wild. I'm not overweight and don't take anything but I do enjoy food. It would be horrible to me to lose the enjoyment of such a primal pleasure. If the choice is between being overweight and giving up the pleasure of eating altogether, I can imagine plenty of gourmands who would rather carry the extra weight for the physical and social pleasures of food. I've heard anecdotal reports of people losing their enjoyment of food permanently, even when discontinuing the drug. Canot confirm but that would be a high cost to pay, imho.

Re: GLP-1 drugs: An economic disruptor? (2024)

#136
post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> That late night trip to McDonalds will have you feeling like shit the next day I've never had this reaction to fast food before. I only eat mcdonalds every few months and yea it's not the highest quality food, but I don't think there's anything in it to make you sick any more than other burger places have. I imagine you'd have to have restricted fast-food nutrition for quite some time before you feel a difference.…

The way I read it, i think the original commenter would usually agree with you, but the effect of the drug turns the post-fast food / treat satiation from joy to pain.

Re: GLP-1 drugs: An economic disruptor? (2024)

#137
post #22
post #10

Earlier quoted context omitted.

As opposed to the good long term effects of being obese?

I realize obesity a major issue for a lot of people. But is it worth giving up your impulses? I mean all of them. I have no proof that's how it works long term, but I do feel the question should be asked before we dive in head first.

Anecdotally, it isn’t really giving up impulses. It blunts the desire for a lot of the ones that are related to consumption.

I can still get a wild idea at 9 pm and lose myself in code. I still see flowers and buy them form my wife without planning. I still have a bowl of ice cream before bed sometimes.

The best way to describe it is that you still have the impulse, but you are able to rationally consider it.

Re: GLP-1 drugs: An economic disruptor? (2024)

#138

Earlier quoted context omitted.

> Yes well your PCP / pharmacist should not have prescribed you an appetite suppressant when you have below average body fat %. Why do you think this? I agree that people who have associated risk factors should be prioritized, but if there's enough for everyone why wouldn't we give it to anyone who wants it?

People who don't need to be chronically medicated should not be. There are always side effects, and we don't even know for sure what the long term risks of these medications are yet. And crowing about saving $200/mo not buying food at Starbucks, well now Novo Nordisk is getting that. Toast a bagel at home for $0.50/day instead.

> People who don't need to be chronically medicated should not be.

If they're like typical westerners, they already self-medicate with coffee every day, with alcohol occasionally, and a big fraction of them (though much less than couple decades ago) also treat themselves with tobacco smoke - and ironically, weight loss is one of the few benefits some people actually use to defend their smoking.

Do they need all that medication? Well, it's socially unfavorable to say so wrt. alcohol, but ask any of the daily coffee drinkers whether they need their morning coffee...

Re: GLP-1 drugs: An economic disruptor? (2024)

#139
> We're discussing the first medication that effectively regulates human impulse control.

Is this another numbing zombie drug, like over-prescribed anti-depressants -- that some people genuinely need, but that make some other people accept a situation that they would otherwise be up to challenging and improving?

Also, are there side effects than can make it backfire for any patients? https://en.wikipedia.org/wiki/Reaver_(Firefly)#Origin

Re: GLP-1 drugs: An economic disruptor? (2024)

#140
post #55

Earlier quoted context omitted.

Yes well your PCP / pharmacist should not have prescribed you an appetite suppressant when you have below average body fat %. The effects are very worth it for people weighing them against heart disease and mobility issues. It's not a Faustian bargain, it's all right on the tin. When you stop taking it the effects go away. If you want to be indulgent and it fits your lifestyle you can reversibly make that decision. T…

After using them, I think GLP-1’s will eventually be rebranded as a weight management / weight maintenance drug rather than a weight loss drug in order to appeal to the masses. It’s a very interesting feeling to feel like you’re in full control of what you eat, not influenced by random cravings or hunger. In my case I’m planning to only stay on it another month or 2 to drop 10lbs. I can easily see people cycling on/o…

In this sense, I see adoption among some people as akin to nootropics or attention management drugs like modafinil. A way to have more control over your own mind. Interesting times, I guess, but caveat emptor.
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