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Weight-loss drug found to shrink muscle in mice, human cells

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Re: Weight-loss drug found to shrink muscle in mice, human cells

#131

Post by tamimio »

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

For that reason HN should just remove the down/up votes, because it will turn this place to an echo chamber like reddit, these brownie points are useless.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#132

Post by NotYourLawyer »

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

To be fair, that comment was about the claim:

> emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle

Which is… obviously bullshit.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#133

Post by vundercind »

delichon wrote: post #19

It also decreases gut motility, which helps with the intended effect of appetite suppression. Young healthy people tend to shrug at that. As an old person that takes it right off the menu even before I read about accelerated sarcopenea. Maybe it's the same effect on the peristaltic muscles.

A bare glp-1 agonist doesn’t, I think, but the weight loss versions are double-acting and do also slow digestion.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#134

Post by sabbaticaldev »

NotYourLawyer wrote: post #132
talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

To be fair, that comment was about the claim: > emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle Which is… obviously bullshit.

they might have confused muscle and lean mass/FFM

Re: Weight-loss drug found to shrink muscle in mice, human cells

#135

Post by astura »

llamaimperative wrote: post #63
throwup238 wrote: post #31

Earlier quoted context omitted.

The next line of the article after that 40% quote: > Carla Prado, a nutrition researcher in the Faculty of Agricultural, Life & Environmental Sciences and lead author on the commentary, explains this rate of muscle decline is significantly higher than what is typically observed with calorie-reduced diets or normal aging and could lead to a host of long-term health issues — including decreased immunity, increased risk…

> The rather obvious problem is that these GLP1 agonists don't improve your diet My understanding from initial anecdotes is this is actually literally wrong. Which was surprising to me, too. But people on GLPs tend to prefer more nutritious food (high protein and high fiber). I'm not sure if this has been studied directly in clinical trials yet but I know that food manufacturers have been reorienting their products t…

>My understanding from initial anecdotes is this is actually literally wrong. Which was surprising to me, too. But people on GLPs tend to prefer more nutritious food (high protein and high fiber).

Not only that but prescribers and patients have noticed that GLP-1 agonists also appear to significantly reduce people's consumption of drugs like alcohol, nicotine and opioids. At least in some populations.

Much more research is needed but right now it's extremely promising that they will have a place in addiction treatment in the future.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#136

Post by abtinf »

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

I agree with your desire for what HN should be, and disagree with your assessment that the top voted comment doesn’t support it.

HN is the only forum I know of that has broadly grasped that most so-called “science” outside of the hard sciences and mathematics is complete garbage and driven by funding needs. The world is awash in non-knowledge. This is an extremely serious issue.

Building the skill to rapidly come to a preliminarily judgement of a headline is crucial.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#137

Post by kbos87 »

There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss.

For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#138

Post by vundercind »

jyscao wrote: post #64

[flagged]

At the very least, we should expect to see the same kinds of downsides you’d see for anyone who managed to eat way, way less and lose weight at a multiple-pounds-per-week rate for weeks and weeks on end without taking a drug to do it. They’d be truly miraculous if they achieved their results without even the same cost as doing the same thing without the drug.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#139

Post by meragrin_ »

siliconc0w wrote: post #126

It's pretty clear that GLP-1 should be prescribed with protein powder. When your appetite is crushed you don't go for the chicken breast, you go for what is immediately appetizing (usually carbs+fats like pizza or fries). IMO this and a lack of resistance training (which should also be prescribed) probably makes up a large % of the muscle loss on these drugs. The problem is that the FDA only looks at dumb measures li…

> When your appetite is crushed you don't go for the chicken breast, you go for what is immediately appetizing (usually carbs+fats like pizza or fries).

Um, when your appetite is "crushed", nothing is particularly appetizing. That is the entire point. It allows one to make better decisions or pass on eating.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#140

Post by [deleted] »

elevatedastalt wrote: post #118
talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

The HN you are yearning for disappeared about 8-10 years ago when it was largely taken over by normies and people way outside the hard-core-tech fold. It's not very different from Reddit front-page now if the topic is even remotely political. For purely technical topics you expect good quality discussion, but those threads barely get comments in the two digits.

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