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Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

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Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#131

Post by astrange »

VyseofArcadia wrote: post #85
throwaway041207 wrote: post #36

Earlier quoted context omitted.

I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…

> barring any life threatening long term side effects There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. My father was on a long-term maintenance dose of immunosuppressant (I think prednisolone, but I could be misremembering) following his kidney transplant. When it was first prescribed to him, the long term side ef…

We've been prescribing semaglutide since 2017 and the predecessor since 2010.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#132

Post by astrange »

sandworm101 wrote: post #42
cthalupa wrote: post #32

Earlier quoted context omitted.

I’ll make my usual response: we know that being obese is basically the worst possible thing you can do to yourself, and the longer you are, the worse it is. The side effects are going to be pretty awful just to negate that, much less all the other things they seem to be good for.

>> being obese is basically the worst possible thing you can do to yourself Lol. I can think of dozens of worse things. Drinking. Cocaine addiction. Meth. Winding up in prison for some reason. Riding a motorcycle without a proper helmet. Getting into a plane flown by Harrison Ford. Even simple unprotected sex can lead to massive medical problems. Ever looked up the average life expectancy of professional athletes, es…

> Drinking. Cocaine addiction. Meth.

Ozempic treats all of those too.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#133

Post by astrange »

Zelphyr wrote: post #91
mbostleman wrote: post #22

Earlier quoted context omitted.

Exactly. I see all these breathless claims of new uses and how wonderful this drug is and wonder when the other shoe is going to drop.

You're getting downvoted here but I think there is precedent behind your statement. History is littered with weight loss drugs that had to be pulled because the shoe eventually dropped. Usually that was addiction or death which, admittedly, neither have been shown in the GLP-1's but, given the history of weight loss drugs, it's not unreasonable in my opinion to be cautious.

GLP-1s are completely different from all those drugs. There's no reason to use them as evidence for it.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#134

Post by astrange »

roody15 wrote: post #44
thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

Hmm not quite. The bigger issue at hand is the large group of metabolic disorders linked to our unhealthy eating habits Alzheimer’s is now often referred to as Type 3 diabetes. This drug in a nutshell partially paralyzes the stomach and upper intestine causing food to move through slowly. This has the effect of reducing food cravings as you literally stay full longer. However slowing down the stomach muscles has many…

> is now often referred to as Type 3 diabetes.

No it isn't. Stop trying to make fetch happen.

> Improving physical activity leveled

It doesn't appear that this is the issue. You can't explain a recent trend (obesity) using something that hasn't changed recently. And exercise is not very effective for weight loss compared to diet (it's something like 20%/80%).

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#135

Post by rustcleaner »

ikanreed wrote: post #62
Someone1234 wrote: post #20

Earlier quoted context omitted.

GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Phen now, and Semaglutide is a third-gen GLP-1). Honestly, this retort can be made about any/all new drugs entering the market. If you had a legitimate retort/critique I'm sure you would have presented it, but this is all we get. This is what happens when you st…

Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize. Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.

Suddenly it's a national security issue.

Suddenly USGov issues emergency production licenses and orders domestically to drop that down to effectively $0.10/kilodose on the market.

Suddenly when Denmark (or whoever) whines, USGov sends a cumulative NATO military defense bill, tells them they are the reserve currency, they have bigger nukes, and tough shit next time don't pork barrel the American people.

Lots of options for Americans; question is, can we be unprincipled enough to take the steps neccessary? :^)

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#136

Post by cthalupa »

Zelphyr wrote: post #91
mbostleman wrote: post #22

Earlier quoted context omitted.

Exactly. I see all these breathless claims of new uses and how wonderful this drug is and wonder when the other shoe is going to drop.

You're getting downvoted here but I think there is precedent behind your statement. History is littered with weight loss drugs that had to be pulled because the shoe eventually dropped. Usually that was addiction or death which, admittedly, neither have been shown in the GLP-1's but, given the history of weight loss drugs, it's not unreasonable in my opinion to be cautious.

I'm not a chemist, biologist, or pharmacologist, but wouldn't it be more reasonable to be cautious based on how analogous the method of action is to other drugs, rather than the effect? GLP-1s don't work in the same manner that phen/fen did, for example.

DNP is an extremely effective drug for weight loss, but no one who knows anything about how it works would think that it would be reasonable to compare it to the GLP-1s, and anyone who knows how it works would also plainly see the dangers around its use.

GLP-1 type drugs have been on the market for decades now as well, and while they are not perfectly safe, we've got a good amount of data around the short to medium term side effects.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#137

Post by kelseyfrog »

lawrenceyan wrote: post #57

Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?

Because other interventions have the consequence of actually working.

If we compare the efficacy of "telling people to lose weight" vs taking ozempic, there is a stark contrast. Pooled results show that education and counselling[sic] did not significantly reduce weight (SMD –0.73, 95% CI –1.89 to 0.42, n = 3 studies; I 2 = 98%)[1]. The mean change in body weight from baseline to week 68 was −14.9% in the semaglutide group as compared with −2.4% with placebo[2].

Telling people to just lose weight is not an evidence-backed intervention to affect weight loss. Continuing to practice it is equivalent to practicing folk medicine or alternative medicine. Despite us wanting it to work, it does not. Like all interventions, pharmaceutical interventions have the possibility of side effects, and it's up to the patient and doctor to weight risk vs reward. There is variation in both for each case, but we have to keep in mind that the mere existence of side effects is not typically a reason for categorically deciding against using a drug.

1. https://pmc.ncbi.nlm.nih.gov/articles/PMC7154644/

2. https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#138

Post by cthalupa »

lawrenceyan wrote: post #57

Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?

Do you think obese people have never tried just eating less? That doctors never tell them to do this and they never give it an attempt?

Yes, it is possible for every obese person on this planet to eat less and stop being fat. 100%.

But for some people, this is actually really difficult to do! And the more fat you put on, the more feedback loops there are in your body that push you towards eating more. Insulin and ghrelin response are big ones, but it wrecks your sex hormones, too - you're almost certain to see massive testosterone drops in men, which further stimulates your body to deposit more fat and build less muscle.

Being told to lose weight by diet and exercise is probably the most prescribed treatment on the planet, and one with one of the absolute lowest success rates.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#139

Post by cthalupa »

VyseofArcadia wrote: post #121
llamaimperative wrote: post #107

Earlier quoted context omitted.

Wow, someone experienced an adverse effect from a drug and are suing? This adds literally zero information.

Gastroparesis is a serious, life-threatening side effect. It occurs in a small number of patients, sure, but maybe that just means I am more risk averse than you. My calculus is simple. I don't need wegovy. I can lose (and am losing) weight without it. Sure, it would be easier with wegovy, but it is not necessary. I am not going to take an unnecessary drug that has a nonzero chance of killing me.

>I can lose (and am losing) weight without it

Excellent! A huge chunk of people try and fail to do this for a wide variety of reasons.

If you can lose weight without the help of a GLP-1 drug, then yeah, that is likely the safest option. But most people aren't choosing between using a GLP-1 drug to lose weight or losing weight without it - they're choosing between staying fat and using the GLP-1.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#140

Post by timcobb »

throwaway041207 wrote: post #82
mjburgess wrote: post #80

Earlier quoted context omitted.

2.5mg?

Still titrating up, will be there in a month.

Can you describe what happened that you don't want to drink?

Edit: oh, I see you describe it elsewhere in the thread. Thank you for sharing.

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