Psilocybin bests SSRI for major depression in first long-term comparison

Post by wizzwizz4 » Sat, Oct 12, 2024, 4:19 PM UTC

jorvi wrote: post #86

striking wrote: post #77

Earlier quoted context omitted.

Psylocybin? Easily? You have to put effort into making an experience with psylocybin meaningful and helpful. It could go wrong very easily, especially for those who are in a difficult situation or headspace. (Speaking from experience.) As for SSRIs? Safe, effective, with a handful of annoying side effects. Straightforward to use, low potential for misuse, requires sustained use for any intended effects. A doctor who…

> Psylocybin? Easily? Err.. no? This is from the Dutch National Institute for Public Health and the Environment: https://www.rivm.nl/bibliotheek/rapporten/340001001.pdf Page 19 onward has the charts. What do do we find at the very low end in terms of chronic and acute toxicity? Shrooms (“paddos”) and LSD. It always blows my mind how anti-drug people will do a handwavey gesture to the authority of institutes like the…

Post by jorgesborges » Sat, Oct 12, 2024, 4:20 PM UTC

_iaoo wrote: post #85

What 2 decades of on & off therapies and meds couldn't fix, a single psilocybin trip fixed in 5 hours. That's all the proof I need. Not even getting into the side-effects of SSRIs including PSSD, brain zaps, lethargy, and a whole lot more. I just don't understand people who do this shit recreationally, as it was quite possibly the worst experience I had in my life.

Post by AnthonBerg » Sat, Oct 12, 2024, 4:20 PM UTC

zozbot234 wrote: post #87

DiscourseFan wrote: post #82

Ok like most of you I’ve taken psychedelic drugs. I’ve had bad experiences sure, but I’m fine now. The issue is that what people generally say, like, “oh sometimes you need to encounter your demons,” maybe that will be temporarily traumatizing—in general people recover from that. The real issues are…more complex. More complex than any diagnoses in the DSM can cover. The brain is very complicated, and everyone’s brain…

Taking psychedelics is a bit like trying to fix a Swiss watch with a sledgehammer: it might just work, but that's not the way to bet. Therapy and well-guided meditative practice can be a lot gentler than that.

Post by phoronixrly » Sat, Oct 12, 2024, 4:23 PM UTC

hackernewds wrote: post #129

DiscourseFan wrote: post #82

Ok like most of you I’ve taken psychedelic drugs. I’ve had bad experiences sure, but I’m fine now. The issue is that what people generally say, like, “oh sometimes you need to encounter your demons,” maybe that will be temporarily traumatizing—in general people recover from that. The real issues are…more complex. More complex than any diagnoses in the DSM can cover. The brain is very complicated, and everyone’s brain…

Did you take it in a controlled environment like the study suggests? Every time serious conversation of medical progress comes up, it's polluted by naysayers with anecdata about how they took it while raving beside a live volcano. We need to give psychedelics a fair chance, and sure after we can discount them. The article suggests at scale there is potential

Post by AnthonBerg » Sat, Oct 12, 2024, 4:24 PM UTC

DiscourseFan wrote: post #102

iancmceachern wrote: post #97

Earlier quoted context omitted.

Yeah, maybe don't take "very high doses". I've not done that. And not had any seriously bad experiences. Maybe like everything else is all about moderation?

It was 500ug of LSD mixed with probably 6 or 7 drinks of alcohol. Suffered serotonin syndrome for a few days afterwards. Regardless I’ve heard stories of people having severe long term psychological issues from even relatively light doses, simply because of how their body in particular interacted with the drug.