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Psychedelic Mushrooms Hit the Market in Oregon

nytimes.com

131–140 of 317 posts

Re: Psychedelic Mushrooms Hit the Market in Oregon

#131

Earlier quoted context omitted.

Same here. Did it once and it saved my life. Point is it was only legally accessible to rich people. I.e. I had to fly to amsterdam pay for pre and post psychotherapy and multi day care. This is so wildly different to recreational use.

Care to share more? How much did it cost and was it a sherpa like experience?

Sherpa?

Re: Psychedelic Mushrooms Hit the Market in Oregon

#132

Here's hoping more accurate dosing will be a side effect of this. Going by rough weight of a plant that includes a lot of water always seemed kind of sketchy to me. I've heard of tinctures made by dissolving them in alcohol, but I don't think even those are measured objectively. No idea what sort of titration/measurement you'd do to determine the mg amount of psilocybin, or if that's even well documented.

It's not the water weight, since they're always dried. Not every mushroom has the same % of active ingredients vs the rest of the dry weight. You could have one big weak shroom or a tiny potent one.

Re: Psychedelic Mushrooms Hit the Market in Oregon

#133
post #3

What's missing from this article is that people are reaching for this because the standard medical treatment for these disorders, SSRIs, are pretty terrible. In the mild case, the common side effects are blunting of your emotions and sexual dysfunction. So you don't have panic attacks, but you live in a gray fog and your relationships suffer. In the worst case, they cause suicidal ideation. Psychedelics also have psy…

Psilocybin works in sort of the same way as SSRI. SSRIs will keep around the serotonin we make, but the problem is, if we’re not making enough serotonin in the first place they won’t be effective.

Psilocybin on the other hand acts kind of like the serotonin molecule itself. It attaches to most of the serotonin receptors, including the two receptor. The reason why it works for so long is you get such a huge and strong attachment to the serotonin receptors that the body ends up, reducing the serotonin receptors in response. It’s this lack of serotonin receptors that make us more sensitive to what little serotonin we make.

There’s nothing non-pharmacological about the effects of mushrooms.

Re: Psychedelic Mushrooms Hit the Market in Oregon

#134
post #59

Been there, done that. Have the postcard. I got to experience the even more fun version where you feel like your death is imminent, you watch your surroundings stop rendering chunk by chunk, and your long term friend is telling you it is indeed all a simulation that everyone but me knew about, and I really was dying (more accurately: going "offline" for an upgrade, and my "spirit" wouldn't be persisted across version…

> It is interesting to observe, retrospectively, how the brain can adopt a new set of axioms and coerce every one of the "senses" into supporting those axioms - no matter how detached from "our typical understanding of reality" (whatever that means) they are. Brainwashing is real. Just make people really emotionally unstable and then hit them with an onslaught of social pressure with a vision.

Yeah KGB, CIA, FSB et al. had that figured out some time ago.

Re: Psychedelic Mushrooms Hit the Market in Oregon

#135
post #19
post #3

What's missing from this article is that people are reaching for this because the standard medical treatment for these disorders, SSRIs, are pretty terrible. In the mild case, the common side effects are blunting of your emotions and sexual dysfunction. So you don't have panic attacks, but you live in a gray fog and your relationships suffer. In the worst case, they cause suicidal ideation. Psychedelics also have psy…

Counterpoint: SSRIs were transformative for my depression. Side effects were minor and manageable (eg, Wellbutrin worked well to prevent any sexual dysfunction). I was on them for several years and had no problem tapering off. My understanding is that this is a pretty typical experience. Rhetoric like this was actively harmful in dissuading me for years from trying what ended up being by far the most effective treatm…

Same for me. It's hard to say exactly what SSRI's are doing for me but I definitely feel better.

The bad sides of of SSRI's are as overblown as the good sides of psychedelics are. It's easy to form an opinion from reading personal experiences online but that doesn't reflect the real world imho.

Re: Psychedelic Mushrooms Hit the Market in Oregon

#136

They've had them in Holland decades ago. Tried them once, was the craziest movie experience I've ever had and didn't feel like repeating this ever again.

I think this is an important distinction many people who are not familiar with the matter miss, psilocybin is not a party drug. I would say psilocybin is closer to say ayahuasca than it is to MDMA or other similar things. A good analogy I once heard is that on party drugs, you're figuratively behind the driver's wheel, whereas on psilocybin you're along for the drive and you'll see where it takes you.

I think this is a misconception about psilocybin and drugs in general. Just like "the dose makes the poison," the dose determines how much control you have. Small doses of acid/mushrooms are very common among partying festivalgoers.

Re: Psychedelic Mushrooms Hit the Market in Oregon

#137
post #19
post #3

What's missing from this article is that people are reaching for this because the standard medical treatment for these disorders, SSRIs, are pretty terrible. In the mild case, the common side effects are blunting of your emotions and sexual dysfunction. So you don't have panic attacks, but you live in a gray fog and your relationships suffer. In the worst case, they cause suicidal ideation. Psychedelics also have psy…

Counterpoint: SSRIs were transformative for my depression. Side effects were minor and manageable (eg, Wellbutrin worked well to prevent any sexual dysfunction). I was on them for several years and had no problem tapering off. My understanding is that this is a pretty typical experience. Rhetoric like this was actively harmful in dissuading me for years from trying what ended up being by far the most effective treatm…

Prozac is my fun drug. It makes me hypo manic with one 20mg dose.

I have schizoaffective disorder, bipolar type So I am prone to being more sensitive to SSRI. This is mostly to do with my genetically odd 5HT2A receptors.

Depression is no longer really a part of my life anymore after I found I was zinc deficient. But now I do tend towards the manic and have issues with psychosis still so I need to be careful with my serotonin.

Re: Psychedelic Mushrooms Hit the Market in Oregon

#138
post #9
post #3

What's missing from this article is that people are reaching for this because the standard medical treatment for these disorders, SSRIs, are pretty terrible. In the mild case, the common side effects are blunting of your emotions and sexual dysfunction. So you don't have panic attacks, but you live in a gray fog and your relationships suffer. In the worst case, they cause suicidal ideation. Psychedelics also have psy…

As far as the risks, I have a friend who's been "microdosing" acid and shrooms for a while, and recently had a legitimate psychotic break, thinking all of her life-long friends were in some kind of Truman Show-esque grand conspiracy against her. She ditched town and cut us all off for over a month. I can't say the drug use caused it, but I and the rest of her friends are of the opinion that it contributed (we all hav…

My experience is that I’ve seen this happen a lot to people who take psychedelics frequently (say, multiple times a month over a prolonged period). Whereas this seems to be rare with infrequent use at moderate dosages.

Re: Psychedelic Mushrooms Hit the Market in Oregon

#139

Earlier quoted context omitted.

Same here. Did it once and it saved my life. Point is it was only legally accessible to rich people. I.e. I had to fly to amsterdam pay for pre and post psychotherapy and multi day care. This is so wildly different to recreational use.

For what it’s worth you can find psilocybin in the US with with right network that does not require exorbitant costs or travel.

Heck, It’s grows in many part of the country!

Re: Psychedelic Mushrooms Hit the Market in Oregon

#140
One issue is that SSRI treatment has to be stopped before starting psychedelic therapy (interactions). This means tapering off until you're not being treated anymore, which takes weeks if not months, can be difficult and put the patient in a less than ideal state of mind, possibly even worse than when they started off.

And this is a very bad state of mind to be in when starting psychedelics. I wonder how people usually deal with that.

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