A conversation with my friend who was a dentistry student, ~2013. > [The friend, let's call her L, trying to dissuade me from drinking some fizzy drink] > J: But I won't get a cavity if the liquid doesn't touch my teeth. > L: Cavities are caused by the ensuing low ph environment, not by contact with teeth > J: Does that mean I can drink as much of it as I want as long as I rinse my mouth with water afterwards? > L, w…
Gene-Engineered Mouth Bacteria
131–140 of 312 posts
Re: Gene-Engineered Mouth Bacteria
#132https://www.cracked.com/article_18503_how-biotech-company-al...
https://www.youtube.com/watch?v=PtPNaMphl04
Also lactic-acid keeps other mouth bacteria under control, do we really want to mess with the balance?
Re: Gene-Engineered Mouth Bacteria
#133They have a pitch deck lamenting 90% of US adults have cavities, and they are 2x likely to get untreated if you are poor, then propose to market this for 20k$/dose. Saving the world, again, startup style.
Re: Gene-Engineered Mouth Bacteria
#134Re: Gene-Engineered Mouth Bacteria
#135They have a pitch deck lamenting 90% of US adults have cavities, and they are 2x likely to get untreated if you are poor, then propose to market this for 20k$/dose. Saving the world, again, startup style.
$20k per dose Jesus H Christ. Rent seeking galore. Hopefully the patent has run out by now and others can get in on the action and make it affordable. There’s no way in hell this could possibly cost $20k. Is capitalism ever going to produce innovation that’s affordable to regular people again and not just benefiting the profiteering VC parasite class?
The patent has run out, and in the ~20y since it expired no one has tried to revive the idea. Why are you faulting the people who are finally picking the idea back up instead of all the people who could have but didn't over the last ~20y?
Re: Gene-Engineered Mouth Bacteria
#136Re: Gene-Engineered Mouth Bacteria
#137The FDA requirements for the original clinical trial were wild: "...the FDA required them to find a cohort of 300 healthy 18-30 year olds who lived alone, not near a school zone, and had fully removable teeth." I can see why this makes sense, but no wonder they failed at enrolling the cohort.
Why the "not near a school zone"?
Re: Gene-Engineered Mouth Bacteria
#138"This has, to our knowledge, caused no ill effects since." That's the kicker. Damn near everything has side effects. How and why the FDA approves some things but not others is a quagmire, but the truth is that almost everything has side effects. Sometimes it feels like every approved drug ad you see on TV will have some lawsuit 20-30 years later. Look at where we are right now with ozempic. We know one of the side ef…
Re: Gene-Engineered Mouth Bacteria
#139Earlier quoted context omitted.
> Longevity biotech came from a similar milieu and has been doing very well They're doing well numerically when it comes to funding but is there anyone who has actually lived materially longer as a result of the field?
Ray Kurzweil will outlive us all, if taking 200 pills a day works: https://www.wired.com/2008/03/ff-kurzweil/#:~:text=He%20is%2... .
Re: Gene-Engineered Mouth Bacteria
#140This is certainly an interesting idea, but there's absolutely no way for anyone to judge whether the claim on this page is bulletproof true, something plausible worth researching more, or just total nonsense. But the fact that there isn't a single link to any scientific paper or evidence whatsoever, or even a single person's name linked to the site (or source of funding or anything ), makes me assume this is just spa…
>are there actual published results from legit scientists on this? The main papers referenced by document on the page are by JD Hillman on 1987[0] (et al) and 2002[1]. A layman review was done few years later by PopSci[2]. This specific site and company appear to have no relation to Hillman or Oragenics (co-founded by Hillman) that holds a patent on this[3,4]. [0]: https://journals.sagepub.com/doi/abs/10.1177/0022034…
https://docs.google.com/presentation/d/1OqDqFYMQdcS0XM4hORqN...