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Cannabis use disorder and subsequent risk of depression and bipolar disorder

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Re: Cannabis use disorder and subsequent risk of depression and bipolar disorder

#132
post #46

Cannabis should be legalized and regulated. Period. People that want to partake ofc should have safe access to it. That doesn't means and has never meant it is a harmless thing, like some groups portray it to be. "it's just a naturally ocurring plant!" Education, more information and less zealotry help on both sides of the discusstion. It's not the devil's lettuce they had people think with 60s propaganda, but it's n…

[deleted]

Re: Cannabis use disorder and subsequent risk of depression and bipolar disorder

#134
post #35

>These findings may inform policies regarding the legal status and control of cannabis use. But not without NNTs. For depression, OR = 1.8, NNT = 12 (assuming 10% lifetime incidence, this is very hard to estimate due to the difficulty in diagnosis). For bipolar disorder, OR = 3, NNT = 25. This is before accounting for any reverse causation: roughly 80% of incidence of BPD is associated with genetic variation.

Could you elaborate?

The Wikipedia article is a good place to start:

https://en.wikipedia.org/wiki/Number_needed_to_treat

So e.g. assuming a fully causal association with bipolar disorder (unlikely due to the strong genetic influence on bipolar disorder) you need 25 people to stop smoking weed to prevent one case of bipolar disorder. You can also calculate it in terms of how many people do you need to imprison to prevent one case of bipolar disorder.

This is particularly revealing when you look at studies giving an odds ratio of 2-3 for cannabis use associated with schizophrenia. The base rate for schizophrenia is 2500. You probably need to imprison hundreds of people to prevent one case of schizophrenia, again assuming the association is causal.

The claim that these studies should impact marijuana legality is just plain bad math.

1: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&d...

Re: Cannabis use disorder and subsequent risk of depression and bipolar disorder

#135
post #130
post #114

Earlier quoted context omitted.

Are you implying there are levels of cannabis use that are zero risk?

GP is not implying anything, they're saying there is a safe level of consumption.

I’m asking if their definition of safe means zero risk. Because that’s the same rationale that the WHO uses to claim alcohol has no safe level of consumption (I.e., there is no level of alcohol consumption that is zero risk).

So either they think there is a level of cannabis use that is zero risk, or they have a different definition of safe consumption that they could elaborate on.

Re: Cannabis use disorder and subsequent risk of depression and bipolar disorder

#137

Earlier quoted context omitted.

With all due respect, your inability to use marijuana responsibly should not make my responsible marijuana usage illegal.

Society does this all the time though realistically. If there is a 1:N chance of harm; and N is low, and we have no idea who will be harmed, we tend to regulate or make illegal. How many societies have legalized marijuana?

There are many things that provably have much higher risk of harm than cannabis but have no serious attempts underway to make them illegal. Unhealthy food. Motorcycles. All kinds of dangerous hobbies. And alcohol of course. The list is long.

I don’t think it has much to do with wanting to help or protect anyone, or else you would see more consistency in the things people want to make illegal. It’s more akin to religious people who think they know the “right” way to live and want to impose those values on everyone.

Many people just have an emotional dislike of cannabis for whatever reason—seeing its effect on others makes them uncomfortable, so they want to stop everyone from doing it. Soda and motorcycles don’t make them uncomfortable, so they don’t care about those.

Re: Cannabis use disorder and subsequent risk of depression and bipolar disorder

#139
post #114

Earlier quoted context omitted.

If you also abstain from alcohol for the same reason then I applaud you. Alcohol has NO safe level of consumption. Unlike cannabis. If you say this while consuming other drugs that are harsher and less safe then you should do some self reflection on your prejudices.

Are you implying there are levels of cannabis use that are zero risk?

I’ve been toking for half my life. The equivalent of having a shot of wine or something mild and barely noticeable like that. I believe at this point i’m incurring close to zero risk. I have my reasons and benefits from microdosing and will continue to do so. I’m also in agreement that cannabis has become very potent, dangerous and abused.

Re: Cannabis use disorder and subsequent risk of depression and bipolar disorder

#140
post #115

Earlier quoted context omitted.

> why certain substances were banned in the first place You obviously have no idea why cannabis was banned in the US. It wasn't banned because of harm to individuals or to society. It certainly can do those things, but there was no scientific basis for the original ban. It was banned because of a massive propaganda campaign by Harry Anslinger, who fabricated evidence that cannabis was a drug of immigrants, non-White…

This is like the people who say that auto company lobbying is the cause of poor public transportation in America. Sure, that is a cause, but there are many other causes as well, and the other causes likely dominate the named cause. Framing it as the cause seems implausible and even cartoonish to me.

For cars, it’s actually even more cartoonish than that. Read The Power Broker; auto-centric urban planning is basically entirely the result of Robert Moses’ insane power and influence (in the same way that the reason everyone has smartphones is basically solely because of Steve Jobs).
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