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Taurine deficiency as a driver of aging

science.org

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Re: Taurine deficiency as a driver of aging

#131

Post by pedalpete »

pmoriarty wrote: post #57
lostmsu wrote: post #28

Earlier quoted context omitted.

Anecdata: a heavy (2 x 8oz cans/day) consumer of Red Bull I got sleep problems starting around 34. Can't be sure they are related, but Red Bull is definitely the main suspect.

I've developed sleep problems as I've gotten older, but I've never touched Red Bull. We can't draw any generalizable conclusions from isolated anecdotes like this.

Sleep naturally degrades as we age. So potentially the "development" is less a result of doing or not doing something versus just the degradation of sleep as a natural part of the aging process.

Re: Taurine deficiency as a driver of aging

#132

Post by pedalpete »

I'd be curious to know why taurine in blood declines with age? Though supplementation is fine, if the diet stays the same, what is happening in the body that makes it unable use the taurine which is naturally in food.

Also, apparently only animal products contain taurine, and vegans have lower levels of taurine.

https://veganhealth.org/protein/taurine-and-carnitine/

Re: Taurine deficiency as a driver of aging

#133

Post by robwwilliams »

Solid study, but the core results are based on a single genotype of mouse — C57BL/6J.

Imagine a clinical study of longevity using 120 clones of you or me. Taurine may be effective at extending lifespan and healthspan of C57BL/6J mice but will it work as well using genetically diverse mice such as the UM-HET3 mice?

Like humans, the UM-HET3 mice are genetically diverse (they segregate for about 11.5 million sequence variants). My hope is that taurine supplementation would work just as well using 120 UM-HET3 mice. A robust finding like that would impress me so much more.

I wish high profile journals—Science and Nature and Cell—would demand that submissions include at least several genotypes of mice. N = 1 studies are just barely worth discussing in HN with respect to humans.

In this case the authors did extend to other models to support their claims but these supplementary components do not test longevity directly.

Having pointed out the downside of this work, I am glad to see this study and will treat it as a promising pilot. Given much previous work my guess, and tacitly, those of the authors, is that taurine supplementation will be beneficial for many genotypes of mice and even humans.

However, there will not be one optimal treatment regimen for all mice or for all humans.

By the way: A 16 oz can of Monster contains 2 grams of taurine.

Re: Taurine deficiency as a driver of aging

#134

Post by abawany »

detrites wrote: post #123
Blackthorn wrote: post #119

Earlier quoted context omitted.

> I mean, why are people even considering artificial sweeteners? Isn't it only because it's taken us all several decades to realise refined sugar is fucked after initially thinking it was great if not at least "safe"? Can't speak for anyone else obviously, I use sucralose to sweeten plain nonfat greek yogurt for breakfast. It tastes like churned asshole without it, but it's otherwise a great food with everything I ne…

Agree on the Greek yoghurt taste. I'd sweeten it with banana, as it can mix nice without much effort and is also packed with nutrients along with only a tiny bit lethal radiation. Calories I've no idea about though.

I've often wondered why grocery stores are infested with flavored yogurts, especially when they are often out of the plain variants that I'm seeking. I've thankfully never felt the need to 'flavor' yogurt and prefer its taste unadulterated - sourer the better.

Re: Taurine deficiency as a driver of aging

#135

Post by Blackthorn »

xcv123 wrote: post #126
Blackthorn wrote: post #118

Earlier quoted context omitted.

You actually posted a link to a news article about a study, not a link to a study. And no, it doesn't contradict my statement that there's nothing wrong with consuming sucralose. It by itself is a piece of evidence, and doesn't by itself override decades of evidence.

The article contains direct links to studies https://www.tandfonline.com/doi/full/10.1080/10937404.2023.2... https://www.bmj.com/content/378/bmj-2022-071204 https://www.frontiersin.org/articles/10.3389/fnut.2022.84839... https://www.mdpi.com/2076-2607/10/2/434 This obviously logically contradicts your statement. Your sophistry is incredible. Let's see how you bullshit your way out of this one.

There's no sophistry here. I simply find the FDA's GRAS finding, and the EU SCF's findings, to be much more convincing than a handful of restricted studies.

You, clearly, do not feel the same, but given that you feel that my position on this is "sophistry" and "bullshit", it is obvious that we are incapable of having an actual discussion on it.

Re: Taurine deficiency as a driver of aging

#136

Post by DoreenMichele »

fnordpiglet wrote: post #128
DoreenMichele wrote: post #24

Taurine is an amino acid, aka a building block of protein. It's found in abundance in meat and seafood. (I had trouble parsing the title of this piece. Insert joke here about how I don't need to read this article because I no longer own a car nor have a driver's license.)

Taurine does not contribute to protein structure. Taurine helps regulate the levels of water and minerals in the blood, contributing to overall fluid balance and proper functioning of the muscles and nerves. Also it acts as a neurotransmitter in the brain. Taurine is found in high amounts in the eye and it's thought to protect against retinal degeneration. Finally Taurine is used in the formation of bile salts. But,…

Thank you.

Re: Taurine deficiency as a driver of aging

#137

Post by qbrass »

quietbritishjim wrote: post #87
redkinght99 wrote: post #8

Taurine? I've been jacking myself full of that since Middle School! Thanks RedBull! Jokes aside, This feels like one of "Wine is Good for you " In moderation and other fine point details. Not buying it.

> The median life span of taurine-treated mice increased by 10 to 12%, and life expectancy at 28 months increased by about 18 to 25%. A meaningful antiaging therapy should not only improve life span but also health span, the period of healthy living. We, therefore, investigated the health of taurine-fed middle-aged mice and found an improved functioning of bone, muscle, pancreas, brain, fat, gut, and immune system, i…

10-12% of a mouse's life is 5 or 6 months. Assuming it's going to extend human lives by 7 years and not 6 months is being optimistic at best.

Re: Taurine deficiency as a driver of aging

#139

Post by xcv123 »

Blackthorn wrote: post #135
xcv123 wrote: post #126

Earlier quoted context omitted.

The article contains direct links to studies https://www.tandfonline.com/doi/full/10.1080/10937404.2023.2... https://www.bmj.com/content/378/bmj-2022-071204 https://www.frontiersin.org/articles/10.3389/fnut.2022.84839... https://www.mdpi.com/2076-2607/10/2/434 This obviously logically contradicts your statement. Your sophistry is incredible. Let's see how you bullshit your way out of this one.

There's no sophistry here. I simply find the FDA's GRAS finding, and the EU SCF's findings, to be much more convincing than a handful of restricted studies. You, clearly, do not feel the same, but given that you feel that my position on this is "sophistry" and "bullshit", it is obvious that we are incapable of having an actual discussion on it.

This is simple logic. It seems that you don't understand the meaning of the word "contradiction"

"a combination of statements, ideas, or features which are opposed to one another."

You wrote that there is no problem with sucralose. I showed studies indicating a problem with sucralose. That is a contradiction.

Then you gaslight us saying there is no contradiction. Sophistry and gaslighting.

This is basic english and logic.

Re: Taurine deficiency as a driver of aging

#140

Post by robwwilliams »

pedalpete wrote: post #132

I'd be curious to know why taurine in blood declines with age? Though supplementation is fine, if the diet stays the same, what is happening in the body that makes it unable use the taurine which is naturally in food. Also, apparently only animal products contain taurine, and vegans have lower levels of taurine. https://veganhealth.org/protein/taurine-and-carnitine/

I am not sure this is true in all strains of mice. Remember these are data generated from a single fully inbred strain of mouse. I am checking now fir s set of 40 strains we have studied to get a better sense of the decline.
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