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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

nature.com

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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#131

Post by Qem »

cerol wrote: post #116

If a cheap, reliable technique of halting or slowing down the "epigenetic clock" hits the market, and assuming its main effect on a population level is increased life span, wouldn't it make the demographics of most developed countries even worse? It's still unclear whether or not "automation" will compensate an ageing population, and prevent a demographic collapse. But having a pill that makes people live longer (eve…

Depends on where the additional years are added. Around the middle of life or in its end.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#132

Post by jeroenhd »

hilbertseries wrote: post #22
astrange wrote: post #6

This article is a bit old (like the other comment about missing year tag says). I think there's newer news that AKG, an easy to get and cheap supplement, has anti-aging effects with no known issues. https://www.science.org/content/article/bodybuilding-supplem...

Anti-aging effects in mice*

If we make these mice strong, smart, and immortal enough, we may convince them to find anti-aging drugs for humans as well!

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#133

Post by realitsflat »

jamesblonde wrote: post #38

Epigenetics is fascinating. I just came back from a project meeting, where i work with people who discovered that HRT (hormone replacement therapy) slows down epithelial cell aging. Epithelial cells are the cells that cover all your vital organs, so they are important for aging. Now, there are even commercial companies that measure Epigenetic age of cells with a technique called DNA methylation. References: https://i…

DNA methylation is not a technique that can be applied. It is a biological system present in your cells silencing expression of genes that are not useful for a cells current behavior. Differently differentiated cells have different "genes methylated" and thus inactivated which govern their behavior and potential for further sub-differentiation. Indiscriminately "reversing methylation" would probably lead to a lot of "cancering".

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#134

Post by aaaaaaaaaaab »

moonchrome wrote: post #97
aaaaaaaaaaab wrote: post #92

Earlier quoted context omitted.

Time to hit up my gymrat brother for some testosterone I guess!

Not sure riding high on dirty test (dosing TRT levels off toilet test going around gyms will be next to impossible) will slow down ageing - but it will probably make you juicy. Make sure to hit the gym to double the gainz.

Oh, forgot to add that my brother is also an MD resident ;) Although he’s doing opthamology :/

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#135

Post by the__alchemist »

throwaway742 wrote: post #28

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

You say this now. How will you feel as your body gradually breaks down, and you stare into the void?

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#136

Post by gwern »

ben_w wrote: post #73
oldgradstudent wrote: post #52

Earlier quoted context omitted.

Super intelligent, immortal, and free of cancer, diabetes, Alzheimer, and MS.

And with a single giant ear on their back. Don’t forget the giant ear. (Weirdly, just saw a breathless article talking about how 3D bioprinting obviates the use of rib cartilage that the human-ear-on-a-mouse 25 years ago was also supposed to end).

Not sure why you're skeptical. That ear is physically on the human woman: https://www.nytimes.com/2022/06/02/health/ear-transplant-3d-... Even if it's rejected or otherwise fails later on, that's a long way from just-in-mice breathless talk.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#137

Post by nick__m »

moh_maya wrote: post #88
refurb wrote: post #42

Earlier quoted context omitted.

Exactly. And this is why the FDA won't approve drugs based on changes to biomarker (which is what these "epigenetic clocks" are) unless a direct link between that biomarker and a beneficial outcomes has been proven.

unless its for Alzheimer's? [0] 'The FDA’s eventual decision to ignore the advice of its advisory committee and approve the drug, it says, was based on aducanumab’s ability to lower levels of amyloid plaques in the brain — protein clumps that some scientists think cause Alzheimer’s.' ... With aducanumab, the agency has shown that it is willing to push the paradigm to a broader set of people. One reason that decision…

I wonder if those amyloid lowering drugs could have a prophylactic effect while having no curative effects. I would love to see a trial in people at high risk of Alzheimer...

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#138

Post by LinuxBender »

giardini wrote: post #20

What are the 3 ingredients? HGH, possibly metformin and what else? The article does not clearly state.

DHEA, Metformin and HGH.

My personal preference is to replace Metformin with Berberine since I can get it online or grow it in a greenhouse and it is less likely to induce lactic acidosis. One can fast for 72+ hours to get a massive spike in HGH. I am not a doctor and this is not medical advice.

I also consume desiccated Thymus in capsule form following the "like improves like" theories.

Here is a video discussing the latest results the article is talking about [1].

[1] - https://www.youtube.com/watch?v=KukRAXnNOJM

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#139

Post by jeppester »

pawelmurias wrote: post #120
jeppester wrote: post #45

Earlier quoted context omitted.

One thing I rarely see mentioned in regards to living forever is that during a life you will accumulate mental scars. My wife has lost a sister, and she's witnessed a murder. Neither she nor I are the same after those experiences. I don't think we will ever be. If we lived forever I think we would all become more and more anxious and excentric as time progressed and our souls inevitably became more "scarred". Maybe i…

Time heals mental scars.

It gets better over time, but not to the point of complete recovery.

I think PTSD is a good example of that.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#140

Post by altgeek »

gdudeman wrote: post #125

Before you run out to get some growth hormone, you should be aware that metformin seems to extend health span and life span quite effectively alone. Even people with diabetes live longer on metformin than a control group that is not on metformin. https://pubmed.ncbi.nlm.nih.gov/25041462/

The issue with metformin is your own personal gastrointestinal sensitivity to it. If you're tried it in the past and quit, people have reported success with the time-released variant. See https://www.drugs.com/pro/metformin-extended-release-tablets...
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