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Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

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Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#131

Post by SuoDuanDao »

netizen-936824 wrote: post #112
SuoDuanDao wrote: post #97

Earlier quoted context omitted.

If you're going to copypaste a statement saying you doubt it had a direct pharmacological effect on a post about a direct pharmacological effect, why not state what you think the issue with the study was?

I'm not referencing the study, I'm talking about the comment that I'm replying to. The study is specifically about the acid versions of the compounds which are not psychoactive CBDA, THCA, and CBGA are all the carboxylic acid forms of the compound which is what is naturally produced by the cannabis plant. When we consume these, we make them psychoactive by heating. This turns them into CBD, THC, and CBG which are dif…

Fair enough as to your objections to linking these anecdotal effects to the study, though it's not the only of its kind and others point to actual CBD as a suspected mechanism[1]. As to your getting downvoted, the way you worded your objection you seemed to be implying the people you were responding to were pointing to THC as the mechanism. If you had been would have been strawmanning, medical uses of Cannabis are rarely about THC alone.

[1] https://www.preprints.org/manuscript/202004.0315/v1?fbclid=I...

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#132

Post by edmundsauto »

somesortofsystm wrote: post #86
edmundsauto wrote: post #66

Earlier quoted context omitted.

As another comment mentioned, this was with non carboxylated cannabinoids. If you’re smoking the leaves then it doesn’t really apply to you.

Not all cannabinoids in the smoke are carboxylated, or at least lets agree that the efficiency of your average conversion is not 100%. Some degree of non-carboxylated cannabinoids can ride those particles too .. for example at the beginning of a joint, the smoke is being drawn through THC fields which have not yet been burned, but may be dislodged and part of the draw as the heated substrate is pulled into the lungs…

Agreed, there may be some applicability of this study on smokers (albeit at a reduced effect size). Worth betting on it being protective? Or just a rationalization?

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#133

Post by netizen-936824 »

SuoDuanDao wrote: post #131
netizen-936824 wrote: post #112

Earlier quoted context omitted.

I'm not referencing the study, I'm talking about the comment that I'm replying to. The study is specifically about the acid versions of the compounds which are not psychoactive CBDA, THCA, and CBGA are all the carboxylic acid forms of the compound which is what is naturally produced by the cannabis plant. When we consume these, we make them psychoactive by heating. This turns them into CBD, THC, and CBG which are dif…

Fair enough as to your objections to linking these anecdotal effects to the study, though it's not the only of its kind and others point to actual CBD as a suspected mechanism[1]. As to your getting downvoted, the way you worded your objection you seemed to be implying the people you were responding to were pointing to THC as the mechanism. If you had been would have been strawmanning, medical uses of Cannabis are ra…

If you smoke cannabis you aren't getting much carboxylic acid cannabinoids at all, for sure nowhere near the amount required to hit micromolar concentrations at an in vivo receptor. Actually the same with CBD because its such a minor component.

I definitely won't argue about the numerous cannabinoids having an assortment of medical uses, but based on my knowledge of behavior and pharmacology the likely mechanism of people avoiding COVID when using cannabinoids for their psychoactive effect is the change in behavior rather than a direct pharmacological action affecting some mechanism of SARS-Cov-2. If its even related at all and not just anecdotal correlation, which is a seriously major possibility

I commented on a comment about using cannabis for the psychoactive effects very specifically, rather than commenting what I stated on the article itself

Now onto the article you posted, I just finished checking it over and I have some concerns.

First, considering this is a supposed pharmacological study I don't see concentrations of active compounds (THC or CBD) listed anywhere. These would be listed as something like uM or nM for micro or nanomolar. Perhaps I missed them and I'm open to anyone pointing out these values to me.

Secondly, this is a preprint study and when you look at the bottom under "competing interests" you can see that it was funded/performed by a cannabis company with skin in the game.

I'm not saying write it off entirely, but I'm very suspicious of the study for these reasons.

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#134

Post by emerged »

suifbwish wrote: post #128
emerged wrote: post #124

Earlier quoted context omitted.

I picked up a cannabis habit in various forms lately, on a daily basis. It has been wild to feel my body react in positive ways. Today I woke up without significant gut discomfort, which is the first time in nearly a decade. Happened immediately after switching from edibles to smoking (just as a temporary experiment).

The next experiment might be from smoking to vaping it. If the benefit is lost, there may be some other active element that arises from its combustion; if not then it might be safer since vaping it would not create any tar.

You just described my exact plan. I’m hesitant even to vape due to health effects but for now I’m just investigating.

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#135

Post by aaomidi »

A4ET8a8uTh0 wrote: post #35
aaomidi wrote: post #17

Earlier quoted context omitted.

I would not listen to a federal govt source's opinions on weed, tbh.

That is painting with a very broad brush. For better or worse, federal government is huge. It is not exactly a monolith. It is made out of people and, not surprisingly, not all of them agree with one another.

Except when the CDC is saying something, it's on behalf of the federal govt. They're also limited in what they can or can not say because of how they've classified weed.

So, if it's coming from an official US govt source and its about MJ, I'm going to be extremely skeptical of it. If they didn't want this reputation, they can actually go ahead and fix the criminalization now, but they're not. So...they deserve that reputation

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#136

Post by sonofhans »

mrmikardo wrote: post #40
sonofhans wrote: post #7

This reminds me of William S Burrough’s “Cities of the Red Night,” in which a deadly plague appears suddenly. The character Dr. Pierson is a heroin addict, and helps discover that heroin is prophylactic against the fever: “A top government official bluntly warned: ‘Virus B-23 now loose in our overcrowded cities, is an agent that produces biologic changes in those affected – fatal in many cases, permanent and heredita…

Thank you for remdinding me of this fantastic book! One of my favourites.

Then you’ll love this — https://www.youtube.com/watch?v=aOa8I7vJJec

I first heard it in this collection, which I bought 20+ years ago — https://www.discogs.com/sell/release/721207. I can’t recommend it enough; Burroughs is fantastic at reading his own work, even blind drunk as he clearly was in some of these recordings.

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#137

Post by mettamage »

Note that [1]

> Even when smoked, THCA-A is only partially transformed to THC. The conversion rates during smoking range from a maximum of 70% under optimized analytical conditions (temperatures higher than 140°C) to simulated smoking processes, where only 30% of the spiked THCA-A was recovered as THC.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549534/

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#138

Post by incrudible »

vmception wrote: post #119
incrudible wrote: post #115

Earlier quoted context omitted.

> A lot of the consternations fall apart, to me, when the aggregate response reaches the same conclusion... Does it though? The other countries that went all in on MRNA vaccines obviously don't have an interest in finding more problems with them. I have yet to see a single good study that determines risk/benefit stratified by age and risk factors. This rather new study shows that risk of Myocarditis is higher with va…

I’m not sold on third doses or more either. Its a mRNA vaccine for two variants ago and we dont use that standard for other viruses. Decent example but this is a separate issue than the premise I started with or replied to. I think myocarditis is a good example of remaining objective with data. At risk people know what they need to do and it is no longer selfish for the rest of us to not help that. Nobody can kill as…

> Decent example but this is a separate issue than the premise I started with or replied to.

I disagree. The question is, is the the system broken or not? To me, this example suggests that it is indeed broken. Then, did it just break or was it broken all along? Is it possible that we mandated vaccinations to millions of people that were more likely to be harmed than helped by these vaccines? If so, would we know, eventually?

The status quo in the pharma industry is to never do more trials than absolutely necessary, lest you risk discovering something that runs counter to business interest. I suspect a very similar attitude would exist among regulatory bodies that risk discovering that it has been advocating a potentially harmful medical intervention to people that didn't need it.

The only entities that have a vested interest in figuring this out are private health insurances. If these vaccines are worth taking, let them charge a premium for refusal.

Re: Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

#139

Post by somesortofsystm »

edmundsauto wrote: post #132
somesortofsystm wrote: post #86

Earlier quoted context omitted.

Not all cannabinoids in the smoke are carboxylated, or at least lets agree that the efficiency of your average conversion is not 100%. Some degree of non-carboxylated cannabinoids can ride those particles too .. for example at the beginning of a joint, the smoke is being drawn through THC fields which have not yet been burned, but may be dislodged and part of the draw as the heated substrate is pulled into the lungs…

Agreed, there may be some applicability of this study on smokers (albeit at a reduced effect size). Worth betting on it being protective? Or just a rationalization?

I don't know if its protective or not, but I do believe its worth finding out.

Wouldn't it be strange if, indeed, weed was the answer to everything.

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