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The most effective malaria vaccine yet discovered

blogs.sciencemag.org

131–140 of 289 posts

Re: The most effective malaria vaccine yet discovered

#131
post #30
post #5

What blows me away is in a study group of 734 infants, which benefited from maternal antibodies against malaria, 717 were infected by malaria in the first year of their life. That's nearly 100%, in the first year since birth. That's devastating. The vaccine is showing 77% efficacy in trials in Burkina Faso. That's an ongoing pandemic that makes covid-19 look like a case of the sniffles. Malaria deaths peaked around 9…

Except for the age difference of the victims, those numbers actually make covid seem pretty bad. Covid has hardly been around for a year and is killing 7x as many people a year.

> Except for the age difference of the victims

Right. Let's all just ignore that the majority of those killed by covid are around the average age of life expectancy, so that we can try and make the unprecedentedly panicked, massively-damaging and downright stupid multi-trillion dollar response to covid appear slightly less irrational and racist.

Starving kills 9 million/year. They're mainly children of colour too, but don't worry - systemic racism is just fine with pretty much everyone when it comes to allocating funds and resources to save those most at risk from preventable death.

Re: The most effective malaria vaccine yet discovered

#132
post #11

Earlier quoted context omitted.

> Malaria deaths peaked around 930,000 a year in 2004, and is around 600,000 a year now Your link does a good job showing this, but for those who don't click and scroll down it's probably worth mentioning that the vast majority of those deaths are in central Africa. So it's not just a lot of deaths, but it's a really significant portion of the population and, as you said, mostly children.

I grew up in Africa. We weren't as scared of Ebola, as we were, of good old Malaria. It's also the gift that keeps on giving. Once you get it, it does a reunion tour, every now and then, for the rest of your life. At the dinner table, we (expats) used to have a bowl of quinine tablets, set out like a condiment. I really hope this works out, because, thanks to climate change, the lower 48 may get a chance to find some…

Malaria used to be common in the US until the 1950s or so. It was eradicated through extensive mosquito control and engineering efforts. Rich countries can cope; it's the developing world that's thoroughly boned, at least until industrial capabilities catch up.

Re: The most effective malaria vaccine yet discovered

#133
post #82
post #5

What blows me away is in a study group of 734 infants, which benefited from maternal antibodies against malaria, 717 were infected by malaria in the first year of their life. That's nearly 100%, in the first year since birth. That's devastating. The vaccine is showing 77% efficacy in trials in Burkina Faso. That's an ongoing pandemic that makes covid-19 look like a case of the sniffles. Malaria deaths peaked around 9…

Although some posts suggest that the USA may experience malaria at some point in the future because of global warming; in actuality, the USA has already experienced malaria. In 1882, the range of malaria in the USA extended from the Canadian border on the north to southern border with Mexico on the south. The only states of the current 48 contiguous states unaffected were Nevada, Utah, Arizona, Idaho, Main, Vermont,…

This is something that has confused me for a long time. America definitely has mosquitoes (I’m from Washington, DC). How are there mosquitoes but no malaria?

Re: The most effective malaria vaccine yet discovered

#134
post #30

Earlier quoted context omitted.

Except for the age difference of the victims, those numbers actually make covid seem pretty bad. Covid has hardly been around for a year and is killing 7x as many people a year.

> Except for the age difference of the victims Right. Let's all just ignore that the majority of those killed by covid are around the average age of life expectancy, so that we can try and make the unprecedentedly panicked, massively-damaging and downright stupid multi-trillion dollar response to covid appear slightly less irrational and racist. Starving kills 9 million/year. They're mainly children of colour too, bu…

Why is it racism, though?

Re: The most effective malaria vaccine yet discovered

#135
post #126

Earlier quoted context omitted.

I don't mean to be crass, but why wouldn't that have worked in Africa? Yes DDT is scary bad, but we seem to be doing ok in the US.

We tried it in Africa. A lot . DDT is great - it's cheap, it's persistent, and there was a heady note of optimism that we might be able to drive malaria to extinction via vector control. Then DDT-resistance developed in the mosquitos. Combined with the health and ecological concerns around it, its use was largely halted. It's been reinvigorated recently as malaria incidence has rose, but it's a trade-off that it woul…

Isn’t DDT resistance a result of so-called “responsible” usage like DDT coated netting instead of overwhelming application such as in the USA? It’s the same principle as antibiotic resistance: under-dosing selects for resistance.

Re: The most effective malaria vaccine yet discovered

#136
post #113

Earlier quoted context omitted.

There's a lot of debate in the field as to whether or not it's actually possible to eradicate malaria. Partially because mosquito eradication programs failed in the core "malaria belt" even with substantial international investment. There is work on this though, primarily around introducing genetically modified mosquitos.

Well, the attempt in Brazil did not go as planned: https://www.dw.com/en/genetically-modified-mosquitoes-breed-... "The hope of the Ministry of Health was to reduce mosquito populations by 90 percent. And this worked well during the field trial. About 18 months after the end of the experiment, the mosquito population returned to what it had been before."

It's was not unexpected that levels bounced back eventually - we'd expect them to, after a small trial lasting only 27 weeks. Arguably if this approach (or the gene drive one) was sustained and combined with the standard treatments we'll get rid of these things or at least malaria.

Re: The most effective malaria vaccine yet discovered

#137
post #107
post #82

Earlier quoted context omitted.

Although some posts suggest that the USA may experience malaria at some point in the future because of global warming; in actuality, the USA has already experienced malaria. In 1882, the range of malaria in the USA extended from the Canadian border on the north to southern border with Mexico on the south. The only states of the current 48 contiguous states unaffected were Nevada, Utah, Arizona, Idaho, Main, Vermont,…

I grew up in Alabama, and remember a few times a summer seeing the "mosquito truck" drive by, spraying pesticide as I played in the yard. I guess it works!

We had those growing up in suburban Chicago too -- in my case in the 70s. The trucks would only appear at dusk. We dumb kids thought the fog was a hoot so we would jump on our bikes and chase behind the truck hooting at the novelty, breathing in who knows what chemicals. I can still remember the smell.

Re: The most effective malaria vaccine yet discovered

#138
post #5

What blows me away is in a study group of 734 infants, which benefited from maternal antibodies against malaria, 717 were infected by malaria in the first year of their life. That's nearly 100%, in the first year since birth. That's devastating. The vaccine is showing 77% efficacy in trials in Burkina Faso. That's an ongoing pandemic that makes covid-19 look like a case of the sniffles. Malaria deaths peaked around 9…

There is an extremely effective treatment. Millions have perished from being denied it. https://www.wsj.com/articles/SB113236412756302115

The Stockholm Convention on Organic Pollutants contains an explicit exemption for DDT used for disease vector control. ( http://chm.pops.int/Portals/0/Repository/convention_text/UNE... page 28.) Your "millions have perished from being denied it" is incorrect. I don't know whether that's the Wall Street Journal's fault, because I won't pay them to find out whether they're wrong.

Re: The most effective malaria vaccine yet discovered

#139
post #82

Earlier quoted context omitted.

Although some posts suggest that the USA may experience malaria at some point in the future because of global warming; in actuality, the USA has already experienced malaria. In 1882, the range of malaria in the USA extended from the Canadian border on the north to southern border with Mexico on the south. The only states of the current 48 contiguous states unaffected were Nevada, Utah, Arizona, Idaho, Main, Vermont,…

This is something that has confused me for a long time. America definitely has mosquitoes (I’m from Washington, DC). How are there mosquitoes but no malaria?

It's only a few (4?) species of mosquito that carry malaria, out of hundreds of species in total.

Re: The most effective malaria vaccine yet discovered

#140

Earlier quoted context omitted.

I dont know what part of Africa you grew up in, but growing up in Nigeria, no one was scared of Malaria. It is treated pretty much the same way Americans treat getting the Flu

I was born in Nigeria. I barely remember it, but what I can remember, is being constantly told how bad it was. It's entirely possible that my parents had an unreasoning fear of it. When we are kids, they are our source of Truth. I also remember my sister getting caught in one of those 'squito swarms, near the Delta. That was freaking awful. Uganda was a bit worse; but we also had other things to be scared of. I shoul…

Well then, nice to meet a fellow Nigerian :) Ebola is a recent thing AFAIK, so it would make sense that no one was freaking out about it when you were a kid.

To be fair, it does sound like you were in rural Nigeria, so my Malaria experience is likely different from yours

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