The situation is also horrible in Brazil (14M cases, 378k deaths, ICUs near full): https://www.nbcnews.com/news/latino/brazil-alarming-high-num... One can only wonder if it's simply a matter of time before variants break through vaccines in the US too.
Eventually there will be a variant which spreads epidemically in even a fully vaccinated population. But such an complete escape mutation is likely to come at a cost to fitness for the virus so it will be less transmissible and virulent. And in vaccinated individuals they will still have cross-reactive immune responses. The 1918 H1N1 pandemic just evolved into seasonal influenza (or co-evolved with the human immune s…
A booster shot has already been developed, and I expect we'll be able to win the arms race against this virus.
[1] https://www.medrxiv.org/content/10.1101/2021.04.06.21254882v...