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Pfizer submits Covid vaccine to FDA for approval, to distribute in December

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Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#131

Post by cortic »

tzs wrote: post #101
lmilcin wrote: post #52

Earlier quoted context omitted.

Well, I wouldn't be so happy. Think about it. Out of million people only small percentage would become infected with covid and of that, only small percentage would die. On the other hand, vaccine must be distributed to everybody. Alternatively to people who, by occupation, have to contact many other people, daily. We don't know yet if there are complications from the vaccine. It is not possible to judge long term eff…

> We don't know yet if there are complications from the vaccine. It is not possible to judge long term effects of anything based on very short exposure ... > Looking at this selfishly and from PoV of game theory, the best decision is to let vaccinate everybody else but don't take vaccine yourself. Obviously, not everybody can make same decision There are two different ways a medicine might have long term unintended a…

3. It does something that is not immediately apparent but develops into a terrible illness/problem year/s later.

If it caused cancer, or auto an autoimmune disease, its likely these wouldn't be apparent for months or years. This is unlikely, but possible, and we could not test for this thoroughly as we didn't have the time.

I also remind you that these companies are immune from lawsuits due to the indemnity clause in their contracts.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#132

Post by blueline »

qwerty456127 wrote: post #114
jbd28 wrote: post #22

Earlier quoted context omitted.

This isn’t a mid 2000s windows OS update. Don’t be part of the problem, take the shot and grow up

> This isn’t a mid 2000s windows OS update. It always is. This can never change. Experience has cemented "always wait for a service pack" as my #1 rule of life.

very scientific

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#133

Post by ericb »

FiberBundle wrote: post #95
refurb wrote: post #61

Earlier quoted context omitted.

As someone who has some experience with clinical trials and drug approvals, I'd be quite comfortable taking the vaccine. A clinical trial size of 40,000 (20,000 receiving the vaccine) is way larger than a lot of other drugs that people are comfortable taking. Is there zero risk of serious side effects? Of course not, there never is. But the trial gives enough data to say the risk is worth the benefit. Edit: The FDA h…

These are all short-term studies. Given that this is a completely new type of vaccine, a certain amount of scepticism about its long-term effects is warranted in my opinion. Personally I fail to see what benefits non-vulnerable people have from immediately being vaccinated.

There's a good portion of people with long-term effects that weren't "vulnerable" but end up with chronic fatigue, lung damage, or mental health problems.

If you compare the frequency of those side effects alone vs. the rarity of side effects we've seen in historical "bad" vaccines, you still end up with a pretty obvious cost-benefit in favor of taking it. From that point of view, "even smaller chance of dying" becomes just a perk.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#134

Post by bluGill »

unnouinceput wrote: post #117
strombofulous wrote: post #48

Earlier quoted context omitted.

I hope so. I would be upset if I got the vaccine and people who didn't have it were allowed to work near me, but I would just keep WFH. I would be outraged if I were forced to work with them

Why would you be upset for? It's their life, not yours. Once you get vaccinated, ideally, you get immune to the virus. You neither can develop the disease nor spread it. It's the same as saying you don't want to work with people who didn't got vaccinated by any other number of vaccines (let you search wiki for full list as exercise) and I'm pretty sure it already happened.

Because it is only 95% effective. If everyone around me is also vaccinated it is likely that even if my vaccine doesn't work I'm still protected. This is what herd immunity is about.

Note that we don't know if vaccinated people can spread covid or not. It seems unlikely, but if it turns out being vaccinated means you become a non-symptomatic super spreader I reserve the right to change my stance based on that information.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#135

Post by unnouinceput »

vharuck wrote: post #128
unnouinceput wrote: post #117

Earlier quoted context omitted.

Why would you be upset for? It's their life, not yours. Once you get vaccinated, ideally, you get immune to the virus. You neither can develop the disease nor spread it. It's the same as saying you don't want to work with people who didn't got vaccinated by any other number of vaccines (let you search wiki for full list as exercise) and I'm pretty sure it already happened.

>It's their life, not yours It's a lot of people's lives, not just theirs. Like with most vaccines, there'll be a fraction of the population who cannot safely get vaccinated. We need to think of this from a public health perspective: more unvaccinated people in spreading-prone situations means more risk to others (including those beyond the immediate situation) and more burden on health systems.

Dude, read my point again. I was asking why would he get upset if is his colleagues decide not to vaccinate. Not anything else.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#136

Post by unnouinceput »

macintux wrote: post #121
unnouinceput wrote: post #117

Earlier quoted context omitted.

Why would you be upset for? It's their life, not yours. Once you get vaccinated, ideally, you get immune to the virus. You neither can develop the disease nor spread it. It's the same as saying you don't want to work with people who didn't got vaccinated by any other number of vaccines (let you search wiki for full list as exercise) and I'm pretty sure it already happened.

* the vaccine is not 100% effective * we don’t yet know whether the vaccine prevents transmission. You can probably be a carrier and spreader even if vaccinated Those two facts alone mean we’re going to be wearing masks for quite some time, things won’t go back to normal for a while, and people are justified in being upset with others who refuse to protect everyone around them.

You really missed my point. Read again my above comment.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#138

Post by bamboozled »

macintux wrote: post #121
unnouinceput wrote: post #117

Earlier quoted context omitted.

Why would you be upset for? It's their life, not yours. Once you get vaccinated, ideally, you get immune to the virus. You neither can develop the disease nor spread it. It's the same as saying you don't want to work with people who didn't got vaccinated by any other number of vaccines (let you search wiki for full list as exercise) and I'm pretty sure it already happened.

* the vaccine is not 100% effective * we don’t yet know whether the vaccine prevents transmission. You can probably be a carrier and spreader even if vaccinated Those two facts alone mean we’re going to be wearing masks for quite some time, things won’t go back to normal for a while, and people are justified in being upset with others who refuse to protect everyone around them.

If we don’t even know a basic facts about the vaccine (whether people vaccinated can still transmit, how long it lasts), isn’t it natural for people too feel concerned about what else we don’t know ?

Seems to be a few unknowns still ?

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#139

Post by try-perforate »

tuna-piano wrote: post #66
justforfunhere wrote: post #2

>> The company has developed specially designed, temperature-controlled shippers for the BNT162b2 vaccine candidate, which can maintain recommended storage conditions (-70°C ±10°C) up to 15 days. Each shipper contains a GPS-enabled thermal sensor to track the location and temperature of each vaccine shipment. Once thawed, the vaccine vial can be stored for up to 5 days at refrigerated (2 - 8oC) conditions. I read som…

I'm curious if anyone knows why Pfizer's mRNA vaccine still needs this while Moderna's mRNA vaccine does not? Has Pfizer just not gone through the proper temperature testing or did they go through that testing and it showed that their vaccine needs to be stored so cold?

Lipid nanoparticle used to envelope and deliver the mRNA. They’re using different makeups which affect the mRNA delivery and stabilization in the vaccine.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#140

Post by jdndbfbf »

bluGill wrote: post #137
gvv wrote: post #29

Well just like I don't immediately update to the latest OS I think I'll wait for the beta testing to happen :)

Too late for that - the beta testers have already found it good. A phase 3 trial is beta test.

I'll let you test it for me and find out what the long term effects are.
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