Live data from Hacker News

Vitamin D deficiency and Covid-19 mortality [pdf]

borsche.de

131–140 of 269 posts

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#131
post #68

Earlier quoted context omitted.

Those dosages are far higher than anyone supplementing vitamin d are likely to take.

They’re single use doses. These are often used by doctors to treat severe deficiency, e.g. weekly 50,000 UI. It is plausible that in an ICU situation with limited time a single, even larger dose makes sense. For an individual not critically ill, more gradual daily boosting of vitamin D is possible. The ICU patients didn’t have this time.

What's the LD50 for vitamin D?

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#132
post #2

Although this is a notable finding it's important to remember that it doesn't lead to the conclusion that supplementing vitamin D will be very beneficial here. When vitamin D is produced in the body naturally via exposure to sunlight there's a huge amount of other things that occur as well, and we don't have a ton of good science to back up if curing a vitamin D deficiency via supplementation of pure vitamin D is rea…

In Finland we put Vitamin D in milk that’s sold on normal shops. And taking a supplement is heavily recommended. Though this is mostly because for 6 months of a year one simply cannot get it the natural way (too cold and sun is too low). And thanks to this we don’t have much deficiency, long time ago we used to have. Not saying it means it would help with covid. But the supplements definitely help with deficiency in…

> In Finland we put Vitamin D in milk that’s sold on normal shops.

Historically, the diet in that region included fish and other foods rich in vitamin D. I'm not sure what's the typical diet like these days.

But yeah, up north you definitely need to increase the intake of vitamin D. Same as Alaska in the US.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#133

Earlier quoted context omitted.

In Finland we put Vitamin D in milk that’s sold on normal shops. And taking a supplement is heavily recommended. Though this is mostly because for 6 months of a year one simply cannot get it the natural way (too cold and sun is too low). And thanks to this we don’t have much deficiency, long time ago we used to have. Not saying it means it would help with covid. But the supplements definitely help with deficiency in…

In the USA we fortify milk with Vitamin-D too, but only a small amount - each 8oz cup (240ml) has 15% (3mcg) of your recommended daily allowance. There's research that suggests that the RDA is way too low, plus many adults don't drink a lot of milk, certainly not enough to make significant impact on their vitamin-D intake. https://www.cdc.gov/nutrition/infantandtoddlernutrition/food... https://www.healthline.com/nutr…

Also, isn't milk consumption unevenly distributed across the whole population? E.g. those with an Asian background I would expect to consume less milk than the population average.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#134
post #89

I've mentioned this before, but my wife is a parathyroid surgeon (parathyroids are the glands that regulate the calcium in your neck) and would beg you to PLEASE monitor your calcium levels if you are supplementing with Vitamin D. She often sees patients on high doses of Vitamin D from well intentioned doctors, but with out of whack calcium levels because of it, and the patients can be very sick without understanding…

Without a reference to go by a quick Google indicates toxicity is only likely by taking far above recommended levels (max recommended is 4000iu daily) for an extended period.

Presumably people on those kind of doses are taking it under medical supervision, or are idiots/under the control of idiots.

I am not a doctor, but without further information it seems that as ever, following the guidance on legit supplies specifically and mainstream medical advice generally is a good rule of thumb.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#135

Earlier quoted context omitted.

In the USA we fortify milk with Vitamin-D too, but only a small amount - each 8oz cup (240ml) has 15% (3mcg) of your recommended daily allowance. There's research that suggests that the RDA is way too low, plus many adults don't drink a lot of milk, certainly not enough to make significant impact on their vitamin-D intake. https://www.cdc.gov/nutrition/infantandtoddlernutrition/food... https://www.healthline.com/nutr…

Also, isn't milk consumption unevenly distributed across the whole population? E.g. those with an Asian background I would expect to consume less milk than the population average.

True, I think food supplementation is hard to do in general since the dose needs to be appropriate for anyone that may consume it, with age ranging from infant to elderly.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#136
post #89

I've mentioned this before, but my wife is a parathyroid surgeon (parathyroids are the glands that regulate the calcium in your neck) and would beg you to PLEASE monitor your calcium levels if you are supplementing with Vitamin D. She often sees patients on high doses of Vitamin D from well intentioned doctors, but with out of whack calcium levels because of it, and the patients can be very sick without understanding…

It seems that you have to balance it with Vitamin K2

https://info.dralexrinehart.com/articles/vitamin-d-and-vitam...

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#137
post #96
post #89

I've mentioned this before, but my wife is a parathyroid surgeon (parathyroids are the glands that regulate the calcium in your neck) and would beg you to PLEASE monitor your calcium levels if you are supplementing with Vitamin D. She often sees patients on high doses of Vitamin D from well intentioned doctors, but with out of whack calcium levels because of it, and the patients can be very sick without understanding…

Would you mind elaborating on what you mean by "wacky" levels? I can't tell from your comment if that means high or low. Asking as a Vitamin D supplement user who uses 2-3k IU a day

Not a doctor, but I have had kidney stones.

The answer is a loss of calcium, so high level found in urine test: if you had way too much vitamin D, then you would start releasing the calcium from your bones.

I don't think that taking calcium supplements would help, because calcium metabolism (https://en.wikipedia.org/wiki/Calcium_metabolism) is much more complex than that.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#138

Earlier quoted context omitted.

I found out on HN that the official daily recommended dose for vitamin D is flawed, it was based on an erroneous statistical analysis. [1] contains some details. The bottom line is the daily dose should be about 8000 IU rather than the official 400 IU. Obviously, 250000 IU or 500000 IU is much higher, but this is a one-shot, not a daily dose. If you take 8000 IU daily dose as correct, then those 2 megadoses correspon…

A few things. Whenever your conclusion is that the "official recommendations are flawed", and those were in place for a while now, scrutinize your process. Reading a post on social media is rarely paradigm-changing - and when it is, it's overwhelmingly in the wrong direction. Secondly, the 8k dose doesn't seem realistic historically. Is there any diet that does not include the products of modern tech, that gets anywh…

Diet wise no. Skin production wise, yes. Though these are different mechanisms and the body can turn off vitamin d production from the skin past a certain point.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#139
post #89

I've mentioned this before, but my wife is a parathyroid surgeon (parathyroids are the glands that regulate the calcium in your neck) and would beg you to PLEASE monitor your calcium levels if you are supplementing with Vitamin D. She often sees patients on high doses of Vitamin D from well intentioned doctors, but with out of whack calcium levels because of it, and the patients can be very sick without understanding…

Thanks for the link and please have her include whether k2 supplementation is recommended or necessary along with the d3. I have been supplementing with k2 due to a history of kidney stones.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#140
post #89

I've mentioned this before, but my wife is a parathyroid surgeon (parathyroids are the glands that regulate the calcium in your neck) and would beg you to PLEASE monitor your calcium levels if you are supplementing with Vitamin D. She often sees patients on high doses of Vitamin D from well intentioned doctors, but with out of whack calcium levels because of it, and the patients can be very sick without understanding…

Without a reference to go by a quick Google indicates toxicity is only likely by taking far above recommended levels (max recommended is 4000iu daily) for an extended period. Presumably people on those kind of doses are taking it under medical supervision, or are idiots/under the control of idiots. I am not a doctor, but without further information it seems that as ever, following the guidance on legit supplies speci…

I've seen mention that the risk of overdose at 10,000iu daily is still very slow.
Post reply on HN