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Compass Pathways has set itself up to be the first legal provider of psilocybin

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Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#131

Post by sierdolij »

dang wrote: post #47
simplecomplex wrote: post #42

“Therapy” is the biggest legal scam in the US. Feeling depressed? Here have whatever chemical psychologists happen to be playing with today! Take some mushrooms, no wait, exercise, no wait, take this, no wait that doesn’t work and is dangerous so take this instead. “Prior to founding Compass, George Goldsmith and Ekaterina Malievskaia, a married couple, did not have experience in psilocybin research or working in the…

Would you please stop posting unsubstantive rants to HN? As you know, we're trying for a bit better than internet default here. Please post civilly and substantively, or not at all. https://news.ycombinator.com/newsguidelines.html

Thank for your work, dang. Long-form personal opinions seem to be better suited on Medium, Twitter, other social media.

TGIF! :D

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#132

Post by sierdolij »

ada1981 wrote: post #66
atomical wrote: post #56

Earlier quoted context omitted.

If psilocybin has some success in early clinical trials then companies will begin work on metabolites and similar compounds that purportedly have less side effects. That is what is happening with Ketamine right now.

What people seem to miss is that it’s the psychedelic experience itself that holds the healing potential. We most likely won’t see a pill derived from mushrooms that cures depression but doesn’t get you high. The altered state of conciousness is the thing.

No, that's unknowable conjecture without a safe-as-possible double-blind placebo of the relevant, individual ligands under hospital supervision.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#133

Post by sierdolij »

kristofferR wrote: post #124
bdamm wrote: post #83

Earlier quoted context omitted.

Unclear. I have close family that is having marked and unprecedented success in treating serious depression by microdosing psilocybin below the psychedelic threshold. The result is profound, sustained, and after trying a dozen different approved psychiatrist prescribed drugs to find help can not be a placebo effect as surely any of those would have been just as effective.

There isn't a clear threshold in regards to microdosing. You're still getting the psychedelic effect from the psilocybin, just proportionally less.

It's uncertain if microdosing a particular ligand has any scientifically-proven evidence of efficacy without studying it. In many instances, it maybe a shared delusion placebo effect and/or socially-reinforced fad.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#134

Post by dang »

sierdolij wrote: post #131
dang wrote: post #47

Earlier quoted context omitted.

Would you please stop posting unsubstantive rants to HN? As you know, we're trying for a bit better than internet default here. Please post civilly and substantively, or not at all. https://news.ycombinator.com/newsguidelines.html

Thank for your work, dang. Long-form personal opinions seem to be better suited on Medium, Twitter, other social media. TGIF! :D

The ones that aren't unsubstantive or flamey are welcome here.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#135

Post by inuhj »

This article is the playbook of how big business enters new industries. I went through this all in 2016 when big money started entering the cannabis industry. The invitations to use people's vacation homes, the fancy dinners, etc. were all part of the experience. They studied my business model and replicated it. They hired researchers and pioneers of the industry and then fired them all within 2 years once they learned everything they need to. In the end--it makes sense. We don't fit their culture and they don't fit ours.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#136

Post by ada1981 »

sierdolij wrote: post #132
ada1981 wrote: post #66

Earlier quoted context omitted.

What people seem to miss is that it’s the psychedelic experience itself that holds the healing potential. We most likely won’t see a pill derived from mushrooms that cures depression but doesn’t get you high. The altered state of conciousness is the thing.

No, that's unknowable conjecture without a safe-as-possible double-blind placebo of the relevant, individual ligands under hospital supervision.

Of course, those studies are certainly underway. And I would bet a non-trivial sum of money that this is the exact result that will be found.

Anyone who has significant experience with healing trauma or mental illness with psychedelics has experienced this phenomenon first hand.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#137

Post by monktastic1 »

johnwyles wrote: post #71
ada1981 wrote: post #66

Earlier quoted context omitted.

What people seem to miss is that it’s the psychedelic experience itself that holds the healing potential. We most likely won’t see a pill derived from mushrooms that cures depression but doesn’t get you high. The altered state of conciousness is the thing.

I'm not saying you're wrong per se but what evidence do you have that there are no beneficial analogs and triggers for similar biochemical pathways that perhaps are not marked by a substantial or profound classically psychedelic experience?

One bit of evidence is that in the JHU studies, improvement correlated strongly with whether the person had a "mystical-type" experience. When you go through an incredibly cathartic experience of remorse and redemption and come out of it a more loving person, it's a good hypothesis that it was the experience that caused the change.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#138

Post by monktastic1 »

basseq wrote: post #35

This is an interesting article for HN. It's spun as a negative, using terms like "threatening", "monopoly", "controversial", and "retribution". You could write it the other way, where an immigrant-founded[1] startup is disrupting the mental health industry. Frankly, most of this seems like par for the course. Of course the company is seeking to push their product to market and commercial viability--and the potential…

Crying when confronted with critical questions, as an apparent strategy to dodge genuine concerns? Stalking social media profiles and tattling on MAPS employees who "liked" critical posts? Showering lavish attention and then suddenly and coldly ending it when they get what they need? It certainly feels underhanded. This may be par for the course in big business, but it's all the more dissonant when the compound in question is meant to make users more compassionate and open.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#139

Post by daveFNbuck »

waynecochran wrote: post #114
RankingMember wrote: post #92

Earlier quoted context omitted.

I wouldn't let someone's knucklehead comment dissuade you from supporting something that would do a huge amount of good for people here in America.

Hey, local knucklehead here. I don't want to live in a place where folks don't get the healthcare they need just because they can't afford it. OTOH, the idea that our individual choices don't affect those around us is naive. Freedom and responsibility go hand in hand.

Freedom and responsibility going hand in hand doesn't mean that hobbies with negative health consequences should be illegal.

Re: Compass Pathways has set itself up to be the first legal provider of psilocybin

#140

Post by daveFNbuck »

RankingMember wrote: post #92
daveFNbuck wrote: post #50

Earlier quoted context omitted.

This attitude is the one thing that keeps me from embracing universal government-provided health insurance. People are so quick to use it as a justification for legal restrictions on behavior.

I wouldn't let someone's knucklehead comment dissuade you from supporting something that would do a huge amount of good for people here in America.

My concern is that this is a popular enough sentiment that universal health care would lead to real reductions in freedom for Americans. I think it's reasonable to be concerned about anything that could contribute to current trends toward totalitarianism.
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