1. Technological improvements for human vision. I have a very special friend who lost vision in one eye because of a detached retina and the failure of ophthalmology to repair it and rewire it to the optic nerve. I want to help her, and other people in the same predicament.
2. Energy. Clean, renewable, highly efficient energy is the most important problem humans have to solve today (IMO). The usual suspects of solar, wind, waves, and "clean" biofuels only make economic sense because of government subsidies, and that situation stinks. We need radically new ideas.