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FDA Authorizes Ten 23andme Genetic Health Risk Reports

blog.23andme.com

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Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#131

Post by gleb »

kregasaurusrex wrote: post #105
gleb wrote: post #96

Earlier quoted context omitted.

Yes, that's exactly what they are saying. That's how they make money. And if that concerns realize that your doctor sells your EMR data, your pharmacy sells your prescription data, the labs sell your blood work data too. https://genos.co/ will do a 75x whole exome sequencing (very good quality even for a clinical test) for $500 with a good customer experience and they don't sell your data. You can then feed the data…

Is there a list of genetic services and what data they provide somewhere, maybe a comparison of sorts? My father recently passed away of arryhtmia and I'm looking for a way to determine if said condition is hereditary or not.

Look on Promethease wiki and Reddit.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#132

Post by psyc »

butisaidsudo wrote: post #4

> For several years, 23andMe has worked on demonstrating that its reports are easy to understand and analytically valid... I guess these are different reports, but I know a genetic counsellor who describes 23andMe's carrier screening tests as "the bane of their existence". Those reports seem not-so-easy to understand based on the patients she sees. One problem is that they warn that your offspring are at high risk fo…

We have to be vigilant, lest our enemy, the good, get the upper hand over the perfect.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#133

Post by adenadel »

TheSpiceIsLife wrote: post #99
adenadel wrote: post #51

Earlier quoted context omitted.

It's not that only 2% _can_ vary, it's that each person has about 2% different from the reference genome (and that 2% is different for every single person).

And only a small subset of that 2% is able to cause pathology pathology. So any diagnosic or risk predictive tests need only check those areas know to result in or increase the risk of pathology.

That's not at all true. For rare, undiagnosed disease we have to sequence the entire genome in order to look for the causative variants. For well understood (common) genetic disease we have small panels, but to say that only a small portion of the genome is informative is not correct. Additionally, there is no way to know a priori which loci will have the variation without sequencing the entire genome.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#134

Post by lawnchair_larry »

berberous wrote: post #128
nojvek wrote: post #125

Earlier quoted context omitted.

Are you saying 23&Me gives you a file with the full list of chromosome's ACGT data? I've always wanted that. Also is prometheus and open source analyzer?

23&Me will let you download a text file with the ACGT data, but only for the SNPs that it has. 23&Me does not sequence your full genome, so the SNPs available are a small subset of your DNA. Prometheus is not open-source (I think), but all it does is read various files with DNA data (like the 23&me export), and match it up with the information in SNPedia (a Wikipedia-like open repository of what we know about certain…

Is it possible to do client side? I'd rather download the db and match it locally than ship my genome to them.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#135

Post by lawnchair_larry »

TheSpiceIsLife wrote: post #94
PeterisP wrote: post #87

Earlier quoted context omitted.

A single error in the very large part of DNA that shouldn't vary per individual but "makes an ordinary human body with normal systems" means that you don't get an ordinary human body with normal systems. Many such errors cause non-viable embryos, but if you have survived up to this point, then such a difference is still quite likely to have a meaningful impact to your health and is precisely the part that you'd want…

That's right. I'm suggesting the average diagnostic test need only concern itself with those areas of the genome that are know to contain mutations that result in pathologies. I think you said the same thing but in a clearer way.

I think the problem is that aside from a handful, they are not known. It's like saying you're only going to copy the parts of a program where bit errors are known to cause problems.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#136

Post by berberous »

lawnchair_larry wrote: post #134
berberous wrote: post #128

Earlier quoted context omitted.

23&Me will let you download a text file with the ACGT data, but only for the SNPs that it has. 23&Me does not sequence your full genome, so the SNPs available are a small subset of your DNA. Prometheus is not open-source (I think), but all it does is read various files with DNA data (like the 23&me export), and match it up with the information in SNPedia (a Wikipedia-like open repository of what we know about certain…

Is it possible to do client side? I'd rather download the db and match it locally than ship my genome to them.

Yes. The author pushes people to the web version since it's more up to date, easier to maintain, etc., but there's a local version, see:

http://snpedia.com/index.php/Promethease/Desktop http://snpedia.com/index.php/Promethease/privacy

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#137

Post by astrange »

decebalus1 wrote: post #73
caio1982 wrote: post #42

Earlier quoted context omitted.

"We will not sell, lease, or rent your individual-level information (i.e., information about a single individual's genotypes, diseases or other traits/characteristics) to any third-party or to a third-party for research purposes without your explicit consent." And... "Unless you choose to store your sample with 23andMe (called consent to "bio-banking", which can be found here and changed in your settings), your saliv…

Yeah, for now but in general, that's useless. They have the leverage to change the policy whenever they want as long as they notify the customers at the login screen and via email. And hey, they can change the policy to not even notify anyone. And of course, they can be bought out and the customer data is part of the company value so there's that. Unless they provide an anonymous way of consuming their product I woul…

Not only your genes worthless, since everyone has genes, but you leave them everywhere, like when you get a haircut.

Might be important if you were planning on a life of crime, or if you owe someone child support. But for the moment there's no good way to use them to make money off you.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#138

Post by astrange »

dionidium wrote: post #30
soneca wrote: post #19

My opinion is that this test is useless at the least and dangerous at the most. It provides information that in almost the totality of the cases no one can correctly interpretate and transform in actionable health advice. Not scientists, not doctors, much less consumers. But it is sold as a cutting edge scientific resource that will improve your life. It wont. Not even increasing the chance that you might avoid somet…

This is the state of just about every trendy consumer health product. My watch tells me my heartbeat? Great. What the hell am I supposed to do with that information? Exactly nothing .

https://www.yahoo.com/tech/apple-watch-helps-man-survive-pot...

It's also good for lessons on why not to drink too much coffee on Adderall.

Actually, this is a lot more useful than checking your own genes once they've already produced you. Generally you've already found all of that out.

Re: FDA Authorizes Ten 23andme Genetic Health Risk Reports

#140

Post by lotharbot »

nommm-nommm wrote: post #112
problems wrote: post #102

Earlier quoted context omitted.

I'd much rather that kind of thing be available as clicking a button personally. Getting information that could help you make big decisions is very useful.

What sort of big decisions does knowing you have Huntington's disease help you make? It's a debilitating disease with no treatment or any way to prevent it.

Knowing about a chronic, untreatable, future illness can help you decide whether or not to have children, and if so, whether to have them earlier than you might otherwise have planned. Likewise it can influence you to accelerate the pace of other life plans (like traveling, or setting up a nonprofit in your neighborhood) and scrap other lower-priority plans.
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