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Magic mushrooms found to lift severe depression in clinical trial

theguardian.com

131–140 of 173 posts

Re: Magic mushrooms found to lift severe depression in clinical trial

#131
post #11
post #8

Earlier quoted context omitted.

Fresh fruit? How are you hungry let alone craving fruit on shrooms?

Eating oranges while tripping on shrooms was a very intense experience to me. I agree with OP's statement, a comfy place with calm music and fresh fruit is all you need.

https://www.youtube.com/watch?v=1hqgYYASenc

Re: Magic mushrooms found to lift severe depression in clinical trial

#133
post #55

Earlier quoted context omitted.

Sounds exactly like every time I smoke weed. Including that disappointing expectation of becoming sober and blissfully unaware of my flaws. Have never tried any psychedelics, but some of my bad "trips" with weed (sometimes involving delusions and hallucinations) make me wary.

We all been there with weed, but the root of this behavior lies within yourself. Weed just makes you more sensitive, which can be amazing provided you know how to (1) confront your demons honestly & (2) find an activity you enjoy. Without (1), you'll never get (2) and believe me, as someone who smokes everyday, (1) will come up from time to time when things aren't going well with your life. That's when you gotta smok…

I think weed is fine for normal people. They seem to enjoy the experience.

I'll admit, I don't think I'm normal. I've had horrid, debilitating bouts with anxiety. Never been clinically depressed, but dysthymia fits me on most days.

That said, I've tried weed at different points in my life. I've tried the weed that's good for pain, low in something? I've tried the uplifting weed. Except for a few times on high school, the experience wasen't that good. I would always need alcohol to counter the negative effects from the weed.

That said, weed didn't work for me. I really wanted a safe drug, I could take daily.

I will add this for the, "Put it through a double blind study, and then I'll discuss the clinical benefits of these drugs?" I'm all for that, but they need to design these double blind studies better. Until they design them better, legalize these drugs. Better? Don't get me started.

Re: Magic mushrooms found to lift severe depression in clinical trial

#134
post #117

Earlier quoted context omitted.

I completely agree with this as I am in the same boat! But what people in their 30s really mean is they are unable to relax because they have so many more obligations and problems on their mind. But believe me -- this problem is remedied by hanging out with good, positive people you trust and removing yourself from a stressful environment.

Nah, for me it's an admission that some things are now harder or impossible to reverse course on. You can't reverse time, and making dramatic changes to your life after you're settled with people depending on you has the potential to upset a lot more lives than your own.

I agree except that I don't see why dramatic changes are necessary after any such experience.

Re: Magic mushrooms found to lift severe depression in clinical trial

#135

Earlier quoted context omitted.

Sounds like you are hiding more things in your life from yourself in the present than you did when you were younger

I've found that as I get older, I'm in positions where because I have a number of responsibilities to my child, partner, coworkers, and community I have to force myself to put various issues "off the table" for conscious thought. These responsibilities often entail dealing with a great deal more ethical ambiguity and have far fewer simple answers. In addition to that, over the years I've learned many new facts about…

Out of curiosity, what are some of these new facts about the world you've learned? I'm in my early/mid twenties and I've suddenly become disillusioned with a whole slew of things, and disgusted by things that didn't use to disgust me, it would be interesting to see if some of our discoveries are similar or if they're really different.

Re: Magic mushrooms found to lift severe depression in clinical trial

#136
Lots of people with positive experiences with psilocybin in this thread. I have also had many incredible experiences and advocate its use, with conditions. But. And this is a very important thing to know before anyone reading decides to try it for the first time.

Psilocybin experiences can be truly traumatic. If you have existing mental health issues, please be very, very careful before you decide to take it. Do all the research you can. I have one friend who went completely over the edge, reached the point of no return. It triggered a predisposition to a horrible mental illness. It has destroyed his life and his familys. For a small number of people, this can happen.

If you think you might be vulnerable to this but still want to go ahead, please make sure you are responsibly and get an experienced sitter and a safe, familiar setting.

Re: Magic mushrooms found to lift severe depression in clinical trial

#137
post #69

Earlier quoted context omitted.

> next to useless No study or scientific curiosity is "next to useless". You are being intentionally antagonistic and there's no need for that. All research has to start somewhere, and this study is a significant start to this field. In no way is it or its conclusions "next to useless".

Agreed. One might say to take the conclusion with a grain of salt, but "next to useless" is being overly dismissive.

No, it is simply a statement of fact. Given that all treatments for depression produce a powerful placebo effect, any non-placebo-controlled trial tells you absolutely nothing about the effectiveness of the treatment. It's true that it does tell you if the treatment is safe, but I think it's fair to say that that information is "next to useless", as there are an almost infinite number of potential treatments. The only way to know if any of them are effective is to do a placebo-controlled trial.

Still, I think it is a plausible treatment, so hopefully there will be some better trials.

Re: Magic mushrooms found to lift severe depression in clinical trial

#138
post #136

Lots of people with positive experiences with psilocybin in this thread. I have also had many incredible experiences and advocate its use, with conditions. But. And this is a very important thing to know before anyone reading decides to try it for the first time. Psilocybin experiences can be truly traumatic. If you have existing mental health issues, please be very, very careful before you decide to take it. Do all…

> I have one friend who went completely over the edge, reached the point of no return. It triggered a predisposition to a horrible mental illness. It has destroyed his life and his family.

Have any details you're comfortable sharing? Particularly the mental illness, what happened when they were triggered and how often they dosed?

Re: Magic mushrooms found to lift severe depression in clinical trial

#139

Earlier quoted context omitted.

Roland Griffiths at John's Hopkins is trying to do proper research on psilocybin, i.e. with control groups. Although it's kind of hard since the effects of psilocybin are rather noticeable. http://www.tedmed.com/speakers/show?id=526372 Just in case anyone here hasn't already seen this: https://xkcd.com/1462/

Not every medical procedure can or has to undergo double blind testing with control groups. Pretty much any treatment that has very aggressive effects is usually done without it. Even treatments that can be tested using a control group are quite often tested without it if you can isolate your metrics well enough. But technically you can still use a control group for psychoactive drugs because in every trial the first…

> possible effects or side effects in order not introduce bias

giving people psychedelics without telling them seems pretty irresponsible to me even in a controlled setting.

Re: Magic mushrooms found to lift severe depression in clinical trial

#140
post #136

Lots of people with positive experiences with psilocybin in this thread. I have also had many incredible experiences and advocate its use, with conditions. But. And this is a very important thing to know before anyone reading decides to try it for the first time. Psilocybin experiences can be truly traumatic. If you have existing mental health issues, please be very, very careful before you decide to take it. Do all…

> I have one friend who went completely over the edge, reached the point of no return. It triggered a predisposition to a horrible mental illness. It has destroyed his life and his family. Have any details you're comfortable sharing? Particularly the mental illness, what happened when they were triggered and how often they dosed?

Sure. They had an incredibly bad time with the trip, far worse than what you usually associate with a bad trip. Violence, screaming, paranoia, gibberish. All stuff (maybe apart from the violence) that can happen on a bad one, but this was extreme. Setting was familiar and safe, no external stresses during the period. This was his first time with mushrooms, although regular cannabis smoker (which also might have caused an issue). Regular dose.

The next few days he was still recovering, but thoughts still very scattered and incoherent. Unfortunately this didn't taper off. I had not seen him for a few weeks until his family were in contact. The behaviour had become drastically worse, violence and paranoia. Eventually he was diagnosed with schizophrenia.

From what I have read, with a certain kind of predisposition it would have probably manifested itself later in his life if he was unlucky.

I don't want to put people off Psilocybin as it can be an incredible thing. Just be damn careful and do your research.

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