Degrees only matter for "serious companies" and are used as a filter by often clueless HR employees without technical background. As long as you can prove practical experience, you should be fine. Your network, on the other hand, becomes more important as you get older. Hiring an unknown person in his/her 40s or 50s has a much lower risk/reward ratio than hiring a random developer in his 20s who will a) do whatever y…
What many other posters here has said is true, you need relevant experience in place of the degree. This is either projects you've worked on or jobs that are appropriate.