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Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

nautil.us

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Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#121

Post by bitwize »

amelius wrote: post #110
bitwize wrote: post #51

Earlier quoted context omitted.

Munk Pack is a good brand. They're like Kind bars but sweetened with allulose.

Thanks for the link. I also hate the sugar alcohols. However: > But allulose isn’t approved for use in Canada or Europe. There, it’s considered a “novel food,” which means it hasn’t been available long enough for sufficient testing, according to those governments’ standards. > And it’s important to know that the FDA’s GRAS status doesn’t mean that allulose has been rigorously tested. > “We don’t have studies regardin…

I don't consume more than like a few grams per day to sweeten things like coffee, as well as the 5g or so in a single Munk bar. I seem to tolerate it well.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#122

Post by arjie »

mh- wrote: post #54
arjie wrote: post #52

Earlier quoted context omitted.

Everyone feels Eternal September sooner or later. I recommend blocking users on this site. Having hit about 800 or so blocks I find that the conversation quality has skyrocketed. You still get one or two low quality users on a thread like this (I hadn’t blocked this guy) but the truth is that it’s usually a few people. Any time a user gives me a flash of annoyance with a nonsensical comment that’s the last time I see…

Yeah, unfortunate that it's come to that, but I think you're right. I started to write a comment about having some (additional) ideas for a Chrome extension, clicked your profile, watched the YouTube video. Fantastic. I think it already does everything I wanted. Thank you for making and open sourcing this!

Ha! I’m glad that scratching my own itch helped you :)

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#123

Post by 46493168 »

bradleyy wrote: post #13

The actual study states in the summary that it's the cardiac protective improvement that reverses, not that you're worse off for having taken a GLP-1. So yeah, when you stop taking something that protects your heart and kidneys, it stops protecting... your heart and kidneys. There's an increasing body of work that indicates that long-term GLP use (initially higher doses for weight loss, then tapering down) retains th…

> So yeah, when you stop taking something that protects your heart and kidneys, it stops protecting... your heart and kidneys.

This is not at all obvious and still requires further study. Do the drugs themselves have heart- and kidney- protective effects, or are the heart and kidneys protected by maintaining a lower weight, or lower resting blood glucose, or lower inflammation, all of which are effects of the drug?

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#124

Post by cthalupa »

ErroneousBosh wrote: post #116
cthalupa wrote: post #90

Earlier quoted context omitted.

Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue. Saying they should try this first at this point in the game is like having your support case escalated 5 times already and them saying "have you tried turning it off and on again"

> Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue. If it's not working for you, it may be because you haven't sorted the "diet" bit. Are you eating "low fat" or "low calorie" things? Because those are not food and they will make you fat. Eat food, just a bit less of it than you do now.

Obviously the calories in are greater than the calories out if the diet doesn't work.

That's not the point.

The point is the vast majority of overweight and obese people try to diet and do not succeed in it.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#125

Post by cthalupa »

storus wrote: post #120
cthalupa wrote: post #96

Earlier quoted context omitted.

> I suspect you have no idea that your body has two independent energetic circuits - one driven by insulin and glucose, the other driver by ketones. I am fully aware - I have spent several years of my life following a ketogenic diet. None of that is relevant for "starvation mode" and insulin within that context. I was replying to your specific points - not providing an explanation on how ketosis works from end to end…

You keep mixing normal carbohydrate metabolism with functional starvation mode when in low caloric high carb diet, i.e. elevated insulin in a low-energy/tired mode with increased cortisol, ramping up gluconeogenesis from muscle tissue, catabolic state from elevated stress hormones, T3 thyroid hormone underproduction, adrenaline spikes leading to insulin resistance beta-andregenic sensitivity downregulation, none of w…

Your body doesn't enter starvation mode until you are in the 4-6% body fat range no matter what your diet is.

I linked 3 reviews/analysis of a large group of studies.

Your study also doesn't argue what you think it argues.

> A total of 33 studies were analyzed, revealing no significant differences between the KD and other diets in muscle mass

But fundamentally it is not a meta-analysis of people on weight-loss diets, it is a meta-analysis of people on keto. Look at the included studies - nearly half of them were on athletes. They weren't tried to lose weight - they were just eating keto. No one is saying that maintaining on keto is going to cause muscle loss.

Your confidence is the problem here - you're throwing around a bunch of words you don't understand and linking studies you didn't read.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#126

Post by meetingthrower »

Teknoman117 wrote: post #26

I’m always kind of envious of the people who were able to lose weight on GLP-1 drugs. I lost a bunch of weight a few years ago, and still need to lose a lot more (430 lb -> 330, goal 240), but I fell out of the good habits for, well, no good reasons… Decided to try Ozempic and was on it for about 6 months. Didn’t do a single thing for my appetite unfortunately, even on the max dose. Sample size of one here, but if yo…

that's too bad. I'm microdosing tirz -- 1/2 the "starter" dose they use to titrate you on, so essentially 1/4 of the therapeutic dose. Totally helped me reduce appetite driven snacking and eating. I still enjoy food, but now I leave half a beer left on the table. No problem. Makes you wonder what free will is like.

I am in a totally different setup than you though - 225 weight, goal to get down to 180 (my Army weight was 170.) I exercise a lot, and lost 30 pounds through diet two years ago. But it was the hardest thing I've done since Ranger school! So paintful to not eat enough. Gained it all back. I'm in month one of tirz and it is as easy as pie.

Re: Discontinuation and reinitiation of dual-labeled GLP-1 receptor agonists

#127

Post by Teknoman117 »

meetingthrower wrote: post #126
Teknoman117 wrote: post #26

I’m always kind of envious of the people who were able to lose weight on GLP-1 drugs. I lost a bunch of weight a few years ago, and still need to lose a lot more (430 lb -> 330, goal 240), but I fell out of the good habits for, well, no good reasons… Decided to try Ozempic and was on it for about 6 months. Didn’t do a single thing for my appetite unfortunately, even on the max dose. Sample size of one here, but if yo…

that's too bad. I'm microdosing tirz -- 1/2 the "starter" dose they use to titrate you on, so essentially 1/4 of the therapeutic dose. Totally helped me reduce appetite driven snacking and eating. I still enjoy food, but now I leave half a beer left on the table. No problem. Makes you wonder what free will is like. I am in a totally different setup than you though - 225 weight, goal to get down to 180 (my Army weight…

Yeah, the 18 months it took me to lose that first 100 pounds was about the most miserable I've ever been in my entire life. Constantly hungry, constantly thinking about food, exercising 3 hours a day, having to sit out of social events because more than half of them involve going to restaurants, etc.

It really opened my eyes to just how food centric society is.

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