Now I only need to find out how to use the 387 gut coprocessor in my belly to crunch those floats.
#include // g stands for gut
Enhancing gut-brain communication reversed cognitive decline in aging mice
121–130 of 194 posts
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#122unrelated but maybe interesting... I had a colonoscopy and had to empty my system. I had 1/2 gallon of this fluid to drink the night before, and the other 1/2 gallon to drink the day of. At that point my digestive system was empty. I will say with an empty system I felt energized and a lot more clearheaded. I wonder if doing this from time to time is helpful to your system, and furthermore if eating smaller portions…
Try intermittent fasting. It's easy. It gives your gut a chance to rest. For me it helped with weight control and slightly improved my overall well being. Later I also eliminated sugar from my diet and reduced caffeine intake to minimum by replacing coffee with reasonable amounts of quality tea. That in turn improved my mood, made me less angry and emotional. I also started exercising a bit. All of that combined increased my energy levels, made me calmer, nicer and a bit more optimistic and happy.
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#123Earlier quoted context omitted.
I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…
> 1. I stopped drinking heavily and using other drugs, i.e. marijuana Heavy alcohol use and marijuana are both known to impact memory and recall directly. Discontinuing both of those explains changes in memory. Attributing this to microbiome changes does not follow.
>Heavy alcohol use and marijuana are both known to impact memory and recall directly.
And who said they don't do this (long term) exactly through their affecting the gut microbiome?
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#124[flagged]
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#125Earlier quoted context omitted.
> 1. I stopped drinking heavily and using other drugs, i.e. marijuana Heavy alcohol use and marijuana are both known to impact memory and recall directly. Discontinuing both of those explains changes in memory. Attributing this to microbiome changes does not follow.
> Heavy alcohol use and marijuana are both known to impact memory and recall directly. And who said they don't do this (long term) exactly through their affecting the gut microbiome?
Or by affecting the kidneys, or by affecting the enteric nervous system, or through some other pathway for which we have no substantial evidence of influencing memory (yet). It just seems like a baseless prioritization of a hypothesis. For some reason, people are specifically fascinated by the gut–brain axis.
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#126Earlier quoted context omitted.
> Heavy alcohol use and marijuana are both known to impact memory and recall directly. And who said they don't do this (long term) exactly through their affecting the gut microbiome?
Or by affecting the kidneys, or by affecting the enteric nervous system, or through some other pathway for which we have no substantial evidence of influencing memory (yet). It just seems like a baseless prioritization of a hypothesis. For some reason, people are specifically fascinated by the gut–brain axis.
>For some reason, people are specifically fascinated by the gut–brain axis.
Might the reason be that we're constantly finding new important ways it affects things, or that we see major changes to seemingly orthogonal issues from targetting the gut microbiome directly?
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#127Earlier quoted context omitted.
> eat what you like and be sure to get a lot of fiber each day Sure sounds like another fad diet.
> Sure sounds like another fad diet. Yeah! A fad lasting millions of years of human evolution, however.
The fad lasting millions of years is "eat what you can get, what is fibre?"
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#128Everyone's "poo-pooing" the article because the title doesn't mention mice, but, FWIW, stories of gut biota affecting humans behavior have been documented for a while. Memory gain is noteworthy, which is the article's "wow" factor, but everyone's just knee-jerk smirking so ... here's a few random articles to gross you out about the wild world of trading microbiota and, for better or worse, changing your personality:…
I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…
So, you stopped being an alcoholic and pothead, and your memory improved?
Wow, it must be those gut microbes!
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#129Everyone's "poo-pooing" the article because the title doesn't mention mice, but, FWIW, stories of gut biota affecting humans behavior have been documented for a while. Memory gain is noteworthy, which is the article's "wow" factor, but everyone's just knee-jerk smirking so ... here's a few random articles to gross you out about the wild world of trading microbiota and, for better or worse, changing your personality:…
In my opinion, gut microbiome stuff is massively overhyped. Here's a study that tried fecal transplants to treat mental illness (and found no effect): https://pubmed.ncbi.nlm.nih.gov/41785480/ The pattern with this stuff is that, when a blinded study is carried out, there's usually no effect.
>The pattern with this stuff is that, when a blinded study is carried out, there's usually no effect.
It must be the case that these microbes need the subject to be aware of their presence! Maybe the microbes have consciousness, and for the treatment to work, the microbes' consciousness has to entangle (via quantum mechanisms) with the subject's consciousness? Blind studies prevent this quantum entanglement to form, that's why the treatment stops working. We definitely need more research in this direction!
Re: Enhancing gut-brain communication reversed cognitive decline in aging mice
#130Earlier quoted context omitted.
To do this eat stuff that grows and not further processed.
Don't be simplistic. Mold on old bread grows and is natural, yet you should not eat it all day.
> you should not eat it all day
How sure are we about this? How certain are we that those specific species of mold have a net negative effect, rather than a net positive (like for example mushrooms)? Penicillium grows on stale foods and I doubt eating it would have a net negative effect.