Earlier quoted context omitted.
If you're running a homelab, the likelihood that you're interested in removing cloud-dependencies from your stack is above average. If that's the case, Tailscale is out. Tailscale is just an added unnecessary external dependency layer (& security attack surface) on top of vanilla Wireguard. And in 2025 it's easier to run vanilla Wireguard than it's ever been.
Normally I'd agree with the philosophy, but I don't really see how you can say this about vanilla Wireguard in particular considering how involved it is, especially if you have more than 2 devices that you want to connect together. Not only do you need to manually manage the keys for each device and make sure they're present in every other device's configuration, but plain Wireguard also cannot punch through NATs and…
Tailscale is great if it meets your requirements, & it probably does for most - I wasn't arguing that at all. Only that it won't be an option for everyone: in particular a non-tiny subset of home server hosters.