> If I wanted to package my Python stuff, though, I'm getting confused. Is it now setup.py or pyproject.toml? Or maybe both? What if I need to support an older Python version as seen in some old-but-still-supported Linux distributions?
Your Python version is irrelevant, as long as your tools and code both run under that version. The current ecosystem standard is to move in lock-step with the Python versions that the core Python team supports. If you want to offer extended support, you should expect to require more know-how, regardless. (I'm happy to receive emails about this kind of thing; I use this username, on the Proton email service.)
Nowadays, you should really always use at least pyproject.toml.
If your distribution will include code in non-Python languages and you choose to use Setuptools to build your package, you will also need a setup.py. But your use of setup.py will be limited to just the part that explains how to compile your non-Python code; don't use it to describe project metadata, or to orchestrate testing, or to implement your own project management commands, or any of the other advanced stuff people used to do when Setuptools was the only game in town.
In general, create pyproject.toml first, and then figure out if you need anything else in addition. Keeping your metadata in pyproject.toml is the sane, modern way, and if we could just get everyone on board, tools like pip could be considerably simpler. Please read https://blog.ganssle.io/articles/2021/10/setup-py-deprecated... for details about modern use of Setuptools.
Regardless of your project, I strongly recommend considering alternatives to Setuptools. It was never designed for its current role and has been stuck maintaining tons of legacy cruft. If your project is pure Python, Flit is my current recommendation as long as you can live with its opinionated choices (in particular, you must have a single top-level package name in your distribution). For projects that need to access a C compiler for a little bit, consider Hatch. If you're making the next Numpy, keep in mind that they switched over to Meson. (I also have thrown my hat in this ring, although I really need to get back to that project...)
If you use any of those alternatives, you may have some tool-specific configuration that you do in pyproject.toml, but you may also have to include arbitrary code analogous to setup.py to orchestrate the build process. There's only so far you can get with a config file; real-world project builds get ferociously complex.