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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#121

Post by hinkley »

angmarsbane wrote: post #94
kjkjadksj wrote: post #26

Earlier quoted context omitted.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

I notice it in people who have never been the weight that they're suddenly walking around as, with them it often looks overdone, too thin for their features etc, but in those who have used it to get back to weights where I've seen them before...I didn't guess. They had to tell me.

I wonder how much of that is losing weight too fast and having floppy skin because of it.

Re: Ozempic shows anti-aging effects in trial

#122

Post by Someone1234 »

godshatter wrote: post #112
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I'm not a fan because it's expensive and once you go off of the drug the weight comes back on (at least from what I've read). That's not a trade-off I want to take lightly. There's also something to be said for gaining the discipline to do it yourself along the way, which may lead to keeping more of the weight off in the long run. We also don't know what the long term side effects of it will be, if any. I don't find…

> We also don't know what the long term side effects of it will be, if any.

The first GLP‑1 receptor agonist was commercially released in April 2005, meaning 20+ years. People who often repeat this: If 20-years, and tens of trials, isn't long enough to "know" then where is the line exactly?

Thalidomide by contrast was available for 4-years, Vioxx for 5-years, and Rezulin for 3-years by contrast.

> There's also something to be said for gaining the discipline to do it yourself along the way, which may lead to keeping more of the weight off in the long run.

That doesn't work; we know it doesn't work both from small and large scale studies, and population evidence since 1970s. So you're promoting the same thing we've been doing, and failing at, for beyond all of my lifetime. Feels like a religious belief at this point, rather than following the data and what we know from it (i.e. that objectively does not work, and has never worked).

Is there something new you know that health experts haven't known as Obesity as increase up through 40.3%+ (with overweight being 73.6%+)?

Re: Ozempic shows anti-aging effects in trial

#123

Post by avoutos »

amanaplanacanal wrote: post #78
riku_iki wrote: post #5

what would be reversing biological age from regular running and eating chicken breast + veggies with olive oil.

Wish I could run. Knee says no.

Do you have an injury? Knees over toes exercises can do wonders for rehab. From a form perspective, it also helps to avoid heel-striking.

Re: Ozempic shows anti-aging effects in trial

#124

Post by hinkley »

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

You've got a crowd of people raised in a Calvinist society who think nothing good comes without suffering, you've got people who feel this is a cheat where discipline should win out, and you have a bunch of people who are used to all easy solutions coming with either a bad lottery ticket or externalities on other people/the environment.

They can all agree that they're waiting for the other shoe to drop.

That said, we are at a point where people are overweight enough that getting exercise has its own risks, and taking a medication that allows you to be more active is likely to cancel out some of those downsides. As long as you do both I have no problem with people taking ozempic, mounjaro, etc.

I would prefer if we figured out what other than cultural changes is making everyone have symptoms of inflammatory dysfunctions. There is more than one thing going on. Processed foods, contamination, some microbe that doesn't culture in agar. And it's spreading to more of the world.

Re: Ozempic shows anti-aging effects in trial

#125

Post by jvanderbot »

blitzar wrote: post #116
jvanderbot wrote: post #61

Earlier quoted context omitted.

With respect, neither of you are qualified to speak for majority of Americans, but given the amount of effort, money, ink, and television dedicated to looking better and losing weight combined with the fact that there's even a thing called fat phobic that even requires definition just to push back on all that ... I think there's sufficient reason to believe that "Overweight = bad" is a common standard that at least p…

We must live on different timelines. Pre ozempic America was the proudest nation of fat people I have ever encountered (excluding the costal elites of course).

It's weird because I agree with you, but also have to acknowledge that the "pushback against fat phobia" was for some reason a thing.

Re: Ozempic shows anti-aging effects in trial

#126

Post by leidenfrost »

kulahan wrote: post #67
cm2187 wrote: post #57

Earlier quoted context omitted.

And also the idea that it is "easy" to lose weight is completely out of touch. If it was there wouldn't be millions of people trying hard, spending money on trying and failing for decades, and entire businesses addressing that. RFK Jr's "let them eat less" is paradoxically the modern version of "let them eat cake"!

I think many people confuse simple with easy. It IS simple to reduce your weight. There are like, two things you need to do. It is, however, VERY hard to actually do those things.

But it's not.

What you're referring to, is the basic concept of thermodynamic calorie in/calorie out. Yes, you can "just" reduce food and lose weight if you hit deficit numbers.

But if you don't do it correctly, you'll feel like trash, you'll suffer bad cravings, and put yourself in a stressful mental situation for days, possibly putting your job at risk.

You have to:

- Eat less than what you're already eating

- But enough to nourish yourself so you keep being in good shape for your work and hobbies

- Manage hunger

- Make the change sustainable so you can keep doing it for the rest of your life.

It's specially hard when your work is entirely sedentary, you live alone and, ironically, when you have a salary that let's you order food every day.

A lot of people don't have it hard. Maybe because they have someone cooking for them at home, because they meal prep the entire week, or because their work is so physically intensive they can just wing it and burn everything with what they need to do for a living anyway.

Re: Ozempic shows anti-aging effects in trial

#127

Post by Someone1234 »

readthenotes1 wrote: post #42
Someone1234 wrote: post #39

Earlier quoted context omitted.

Generic Semaglutide is already produced on a massive scale throughout the world. However, it is unlawful to import and sell and will remain so until 2032 in the USA. In other markets, where it is under patent, it is significantly cheaper than the $500/month or more in the US currently. For example in the UK it is roughly $150/month USD privately (i.e. not through the NHS). In China it will be out of patent within two…

Iirc, that pricing will change in the US as Trump will require that the price of drugs to Medicaid patients must match or be less than that of any other developed nation. Since about 1/4 of the people in the US are on medicaid, close to 90 million, that means the drug manufacturers will probably raise the price for everyone else in the US because they got to get their profits somehow... https://www.whitehouse.gov/fac…

Unfortunately, per the link, it sounds like a voluntary arrangement. Essentially they're asking drug companies nicely to stop ripping off Americans.

If they're serious about this, they would introduce legislation rather than send strongly worded letters to pharma companies.

Re: Ozempic shows anti-aging effects in trial

#128

Post by rglover »

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Well, considering that the drug was originally developed not for weight loss but for type 2 diabetes management, it's not terribly radical to be skeptical or outright dismissive of it as some miracle weight loss drug (even if that is a consistent side-effect).

The whole rush to get people on the thing feels like an opportunistic pharma grab (because it is). The outcome of those sorts of things is never in favor of the individual or their well being.

Re: Ozempic shows anti-aging effects in trial

#129

Post by alistairSH »

n8cpdx wrote: post #83
alistairSH wrote: post #38

Earlier quoted context omitted.

I've read (anecdotes from people in the fitness/body-building space) that the default dosing could be too high for many people. And the side-effects seem to ramp up with the dose. IE, if you're getting weight loss at 1/2 the default dose, you might want to stay there, even if your MD wants you to increase to the default. [default uses loosely here - people build up from a low dose over the span of weeks/months] And t…

I tried it. I started down about 80 lbs from my heaviest, but a good 40 lbs from ideal/20 lb from healthy weight. The first time I tried it I followed dosing guidelines for ramp up; side effects were horrible, didn’t lose much weight, and it just kept getting worse. Second time, after a few months off, I started at lowest dose and stayed there. Side effects were better to start but ramped up again. Eventually my dige…

Have you looked into Tirzepatide? Basically a combo of ozemspic plus a GIP drug. Again, anecdotes from bro-science, but appears to allow lower dosing and reduced side-effects.

Re: Ozempic shows anti-aging effects in trial

#130

Post by rglover »

hinkley wrote: post #124
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

You've got a crowd of people raised in a Calvinist society who think nothing good comes without suffering, you've got people who feel this is a cheat where discipline should win out, and you have a bunch of people who are used to all easy solutions coming with either a bad lottery ticket or externalities on other people/the environment. They can all agree that they're waiting for the other shoe to drop. That said, we…

> That said, we are at a point where people are overweight enough that getting exercise has its own risks, and taking a medication that allows you to be more active is likely to cancel out some of those downsides.

And yet we rarely ask or say "maybe I should just eat fewer calories?" Unless you have some other disorder that prevents normal bodily function, that does work (and would be viable I'd imagine for the majority of people being prescribed).

But it requires patience and discipline which are basically non-existent for the majority of the population.

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