GLP-1 drugs: An economic disruptor? (2024) • Hacker News Board

Re: GLP-1 drugs: An economic disruptor? (2024)

#121

Post by brokensegue » Sat, Mar 01, 2025, 9:05 PM UTC

xboxnolifes wrote: post #89

brokensegue wrote: post #26

Earlier quoted context omitted.

40% of Americans are obese and way more are merely overweight. Either your office is small, a huge fluke, weirdly selected or you're not observant enough.

6th option: They are overweight, but do not know, so they don't recognize what overweight looks like. But also, it's pretty easy to not look overweight if you're not obese. 30 pounds can be as little as a few waist sizes. I can gain and lose 15 pounds without looking like I changed at all.

That counts as not observant to me

Re: GLP-1 drugs: An economic disruptor? (2024)

#122

Post by GZGavinZhao » Sat, Mar 01, 2025, 9:07 PM UTC

mhb wrote: post #85

GZGavinZhao wrote: post #70

I would feel like an absolute failure if I need medicine to help create willpower. EDIT: under the assumption of an average person who is not under any medical condition that may result in lack of willpower

How would you feel if you were born with an unusual and detrimental somatic condition that could be fixed with medicine?

Updated, I should clarify that assuming no medical needs.

Re: GLP-1 drugs: An economic disruptor? (2024)

#123

Post by slevis » Sat, Mar 01, 2025, 9:07 PM UTC

casey2 wrote: post #86

slevis wrote: post #56

Earlier quoted context omitted.

Because the author assumes that the drugs are not only anti-obesity drugs but impulse controlling

Correctly assumes*

Well, the author did not reference any actual studies. But some people here have shared an effect on their general impulse control. Do you have any pointers to good studies about this effect?

Re: GLP-1 drugs: An economic disruptor? (2024)

#124

Post by ReptileMan » Sat, Mar 01, 2025, 9:09 PM UTC

Sounds dystopian. And also Ozempic face. To me it seems that it doesn't activate all fat cells in the same way natural weight loss does. I do have a feeling that GLP-1 agonists will eventually bite us in the ass. Usually this is the way with molecules that are too miracle - hello cocaine, plastics, teflon and amphetamines. There may be some spectacular risks that will become evident after decades.

Re: GLP-1 drugs: An economic disruptor? (2024)

#125

Post by SoftTalker » Sat, Mar 01, 2025, 9:09 PM UTC

layer8 wrote: post #92

cj wrote: post #55

Earlier quoted context omitted.

After using them, I think GLP-1’s will eventually be rebranded as a weight management / weight maintenance drug rather than a weight loss drug in order to appeal to the masses. It’s a very interesting feeling to feel like you’re in full control of what you eat, not influenced by random cravings or hunger. In my case I’m planning to only stay on it another month or 2 to drop 10lbs. I can easily see people cycling on/o…

A rebranding to a non-prescription drug will depend on how the prevalence × severity of side effects [0] turns out longer-term. I hope that you are right, but it seems too early to tell. [0] https://www.sciencedirect.com/science/article/pii/S266736812... https://www.gov.uk/drug-safety-update/glp-1-receptor-agonist...

"Gastrointestinal side effects" I assume that is code for excessive and frequent evacuation of watery feces.

Re: GLP-1 drugs: An economic disruptor? (2024)

#126

Post by dehrmann » Sat, Mar 01, 2025, 9:09 PM UTC

Interesting article, but I do have a nit:

> Nike is shifting from "Just Do It" impulse messaging to long-term wellness partnerships

My read of "just do it" is actually the opposite. It's a message to dedicated athletes about not making excuses end executing.

Re: GLP-1 drugs: An economic disruptor? (2024)

#127

Post by SoftTalker » Sat, Mar 01, 2025, 9:10 PM UTC

aeturnum wrote: post #110

SoftTalker wrote: post #67

Earlier quoted context omitted.

People who don't need to be chronically medicated should not be. There are always side effects, and we don't even know for sure what the long term risks of these medications are yet. And crowing about saving $200/mo not buying food at Starbucks, well now Novo Nordisk is getting that. Toast a bagel at home for $0.50/day instead.

I am not an expert but my impression is semaglutide has been in development since the 90s and in use as a drug for about a decade for people with diabetes. The drug and mechanism are old, the use is new. I do not agree that people who don't "need" to be chronically medicated should not be. I think you can decide to take whatever you want for your own reasons. I am not going to tell you what you can and and can't take…

I was giving advice, not proposing a prohibition against doing what you want to do. It's your body, and your health.

Re: GLP-1 drugs: An economic disruptor? (2024)

#128

Post by GZGavinZhao » Sat, Mar 01, 2025, 9:10 PM UTC

cedws wrote: post #106

GZGavinZhao wrote: post #70

I would feel like an absolute failure if I need medicine to help create willpower. EDIT: under the assumption of an average person who is not under any medical condition that may result in lack of willpower

This is the same line of thinking as "drug addicts should just stop doing drugs."

Apologies, I've updated to clarify that my comment is under the assumption that the host is not already under a non-natural influence or medical condition. For example, in the case if there is a medicine that would help drug addicts with their addiction I would be 100% for it.

Re: GLP-1 drugs: An economic disruptor? (2024)

#129

Post by furyofantares » Sat, Mar 01, 2025, 9:10 PM UTC

GZGavinZhao wrote: post #70

I would feel like an absolute failure if I need medicine to help create willpower. EDIT: under the assumption of an average person who is not under any medical condition that may result in lack of willpower

I guess people whose strengths and weaknesses differ from your own should feel like absolute failures then.

Re: GLP-1 drugs: An economic disruptor? (2024)

#130

Post by casey2 » Sat, Mar 01, 2025, 9:12 PM UTC

willis936 wrote: post #39

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

Yes well your PCP / pharmacist should not have prescribed you an appetite suppressant when you have below average body fat %. The effects are very worth it for people weighing them against heart disease and mobility issues. It's not a Faustian bargain, it's all right on the tin. When you stop taking it the effects go away. If you want to be indulgent and it fits your lifestyle you can reversibly make that decision. T…

I assume GP isn't a woman, why do you think 20% is normal for men. The point is that there are no side effects and there is no reason to stop taking it, especially if it saves him money.

Are you just using average as weasel words here? I get my best pump and generally have the best workout sessions at ~10-12%, which is easily maintainable for me, but definitely not for most people, having a drug that makes it effortless for most people is a GOOD thing. People shouldn't have to suffer to get to And what about strength athletes who want to build up a large runway? Now literally all of them can get down to ~7% no problem, and have no problems on the way up either.