Live data from Hacker News

Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

apnews.com

121–130 of 163 posts

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#121
post #73

Earlier quoted context omitted.

The problem is the cost, in Europe and the USA the treatment is over $40,000 USD per year, which isn't realistic for regular people.

Every gay person I know, myself included, is on prep. From the VP at a Fortune 500 on down to a coffeeshop barista. Cost is not an issue, at least not in the United States.

How does wide spread PrEP use affect sexual behavior?

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#122
post #104

Earlier quoted context omitted.

Seen these on commercial, I wish they stop with commercial for meds. Depressing asf, keep reminding me of my mortality while I’m trying to relax and enjoy a moment

Do you mean you don't want to be reminded of the risk of STDs when about to engage is sex?

I was talking about med ads in general, and yes I don’t need to be reminded humans can get stds from unprotected sex, nor I think that is a place for it

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#123
post #42

Earlier quoted context omitted.

They are however effective in preventing transmission of many other STDs that PREP doesn't prevent (and that PREP perhaps indirectly contribute to increasing transmission of including antibiotic resistant STDs).

Yeah, my comment wasn't meant to be anti-condom

Fair enough.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#124
post #119
post #57

Earlier quoted context omitted.

Not vitamins but vrious meds in my case. And a very chaotic lifestyle at times. The meds are always next to bed, and a pouch with meds for when I travel, plus a set of them in my backpack in case I sleep out of home. When I was in a relationship and we lived separately, I had two sets - one on my place, another in my gf’s place. It’s a bit like “how do you manage to brush your teeth daily if you have a chaotic routin…

> It’s a bit like “how do you manage to brush your teeth daily if you have a chaotic routine”. That doesn't move me away from my hunch that the jab is more convenient for many. Studies show that around 30% of people faily to brush the recommended twice a day.

they weren't trying to move you. They were very explicit about commenting on human differences.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#125
post #12

Earlier quoted context omitted.

A few reasons: - Women and girls make up the majority of HIV cases, especially in the developing world - If you're estimating the effect in both men and women, you're reducing your power to detect an effect in either group. If you have a limited budget, it's going to be hard to recruit, etc., you may well be better off powering your study for the group you think is going to be the most impactful, then going back. We…

That's inaccurate. The vast majority of all cases are in men. For instance in America only 22% of HIV+ people are women. Our World In Data has a map that shows this visually: https://ourworldindata.org/hiv-aids The only place this isn't true is sub-Saharan Africa. As there's no biological explanation for that discrepancy it's been hypothesized that it's because in Africa a lot of reported HIV cases are fraudulent, du…

There is a societal reason; condom use and polygamy. Condom use is less common and polygamy more amongst straight people in sub saharan Africa.

There was also very prominent AIDS denialism up to the 2000s so there was a bunch of lost time leading to an explosion in infections; the most notable example being South African president Thabo Mbeki.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#126

Earlier quoted context omitted.

Every gay person I know, myself included, is on prep. From the VP at a Fortune 500 on down to a coffeeshop barista. Cost is not an issue, at least not in the United States.

How does wide spread PrEP use affect sexual behavior?

Pretty much exactly what you expect given than promiscuity is not taboo in the gay community.

All in all, HIV just isn't a problem anymore. It's on the same sort of threat scale as any other STD. Even if you're infected, you just continue taking PrEP (technically PEP) for the rest of your life and that's about it. Normal life expectancy and not much other health complications for most people with consistent treatment.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#127
post #71
post #3

> and results published Wednesday show it worked nearly as well in men. So not as well? Is there a biological reason for this? Also, is it typical to do such studies on single genders rather than on a mix of humans?

The receptive partner in sexual activity is at much higher risk of infection than the penetrating partner.

Soooo we should've seen the opposite outcome given that fact?

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#128

This is incredibly exciting! The main method available for PrEP, in the United States, at least, is a daily pill. I think (I don't know) there is a monthly shot, too. Daily pills take a lot of time investment; monthly shots are better; but once every 6 months is awesome! Especially in circumstances where it might be difficult to guarantee a daily pill or even a monthly shot.

There is a generic daily pill (Truvada), a more expensive one (Descovy) and an every two months shot (Apretude.) Apretude has lower efficacy than Descovy or Truvada, but once you factor in human error in taking a daily pill regimen, it is more even. Human error is a significant factor since the current treatment protocols say if you’re not sure whether or not to take it, it is safer to skip than to accidentally doubl…

The data I've seen shows apretude is more effective, not less

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#129
post #73

Earlier quoted context omitted.

The problem is the cost, in Europe and the USA the treatment is over $40,000 USD per year, which isn't realistic for regular people.

Every gay person I know, myself included, is on prep. From the VP at a Fortune 500 on down to a coffeeshop barista. Cost is not an issue, at least not in the United States.

I believe you might be referring to tablet-based PrEP, that treatment is a few hundred dollars a year depending on your geographic region.

The $40k+ price is the cost of the 2x pa injectable form. This is a relatively newer treatment and not widespread.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#130
post #73

Earlier quoted context omitted.

The problem is the cost, in Europe and the USA the treatment is over $40,000 USD per year, which isn't realistic for regular people.

Isn’t that the starting price? Insurance and countries can buy in bulk and bring it down. Then overtime doesn’t the price come down due to competition from generics?

The $40k price is the current price in the USA.

Generics aren't possible in markets where the patent holder enforces their rights. The article is about how Gilead will allow certain poverty ridden countries to access the drug without the need to pay a licensing cost (i.e. they can receive a "generic").

Post reply on HN