Weight-loss drug found to shrink muscle in mice, human cells • Hacker News Board

Re: Weight-loss drug found to shrink muscle in mice, human cells

#121

Post by anon291 » Thu, Nov 21, 2024, 1:47 AM UTC

throwup238 wrote: post #31

cm2187 wrote: post #13

> emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle That's the sort of headlines that smells like bullshit to me. My understand of those drugs is that they don't actually make you lose weight, they just cut your appetite so you can follow a diet to lose weight without hunger hammering at the door. So to start with, if that's the case, all they are…

The next line of the article after that 40% quote: > Carla Prado, a nutrition researcher in the Faculty of Agricultural, Life & Environmental Sciences and lead author on the commentary, explains this rate of muscle decline is significantly higher than what is typically observed with calorie-reduced diets or normal aging and could lead to a host of long-term health issues — including decreased immunity, increased risk…

Part of the problem is that doctors recommendunhealthy diets and will dismiss healthy diets.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#122

Post by PittleyDunkin » Thu, Nov 21, 2024, 1:49 AM UTC

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

What exactly do you think this forum is if you think this forum is above such sentiments?

Re: Weight-loss drug found to shrink muscle in mice, human cells

#123

Post by devmor » Thu, Nov 21, 2024, 1:50 AM UTC

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

After I saw yesterday’s thread about politics in science was flooded with new sockpuppet accounts named after slurs spreading filth and downing everything they don’t agree with I no longer expect anything meaningful from comments here.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#124

Post by anon291 » Thu, Nov 21, 2024, 1:50 AM UTC

throwaway2037 wrote: post #85

throwup238 wrote: post #31

Earlier quoted context omitted.

The next line of the article after that 40% quote: > Carla Prado, a nutrition researcher in the Faculty of Agricultural, Life & Environmental Sciences and lead author on the commentary, explains this rate of muscle decline is significantly higher than what is typically observed with calorie-reduced diets or normal aging and could lead to a host of long-term health issues — including decreased immunity, increased risk…

> nutrient deficient diet (which is probably a majority of Americans) This is bullshit. Literally, I Googled for: what percent of americans have nutrient deficient diet? First hit is some blogspam trying to sell me "Nutrient Therapy". Second hit is CDC: https://www.cdc.gov/nutrition-report/media/2nd-nutrition-rep... > The Second Nutrition Report found less than 10% of the U.S. population had nutrition deficiencies fo…

Part of the problem is that the standards are incorrect. If you go by dietary standards, you are eating way too many carbohydrates and likely eating too many times a day, especially if you do not have an active job.

Most people should mainly be eating fat and protein with a decent amount of grains and fruit and vegetables. However, the standard advice is to eat a lot of grains, some fruit and vegetables, a modest amount of protein, and little fat. This is awful and leads to very high hunger. Especially if you eat multiple meals a day, as is also commonly recommended, this is a recipe for being ever hungrier day by day.

It wasn't until I eschewed all advice, started eating one big meal a day and maybe one snack and matching my carb intake with my fat intake that the hunger that I had known since childhood magically disappeared and I lost 25 lbs (and am losing more). Finally a 'normal' weight seems not only in sight, but extremely easy!

Re: Weight-loss drug found to shrink muscle in mice, human cells

#125

Post by [deleted] » Thu, Nov 21, 2024, 1:51 AM UTC

elevatedastalt wrote: post #118

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

The HN you are yearning for disappeared about 8-10 years ago when it was largely taken over by normies and people way outside the hard-core-tech fold. It's not very different from Reddit front-page now if the topic is even remotely political. For purely technical topics you expect good quality discussion, but those threads barely get comments in the two digits.

[deleted]

Re: Weight-loss drug found to shrink muscle in mice, human cells

#126

Post by siliconc0w » Thu, Nov 21, 2024, 1:52 AM UTC

It's pretty clear that GLP-1 should be prescribed with protein powder. When your appetite is crushed you don't go for the chicken breast, you go for what is immediately appetizing (usually carbs+fats like pizza or fries). IMO this and a lack of resistance training (which should also be prescribed) probably makes up a large % of the muscle loss on these drugs. The problem is that the FDA only looks at dumb measures like weight lost, not body fat % when approving these drugs.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#127

Post by turbojet1321 » Thu, Nov 21, 2024, 1:54 AM UTC

throwup238 wrote: post #111

ohyes wrote: post #66

Earlier quoted context omitted.

> Losing weight without losing muscle mass is very hard. Yes it is. > It requires extreme diets like a protein sparring modified fast where 80%+ of your calories are from lean protein while running a 50% caloric deficit. I’m not any sort of expert but that sounds frankly, dangerous. I don’t see how you do something like that without damaging your liver. It’s very possible to lose weight and gain muscle, but you have…

> I’m not any sort of expert but that sounds frankly, dangerous. I don’t see how you do something like that without damaging your liver. I haven’t seen any credible research that a healthy person can damage their liver from excessive protein intake. Someone suffering from liver disease needs to be careful, sure, but evidence that it would harm a healthy liver is practically nonexistent. That said, PSMF is explicitly…

> If it were as simple as that, we wouldn’t be having this conversation.

It pretty much is that simple. The problem is that simple is not easy.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#128

Post by patrickhogan1 » Thu, Nov 21, 2024, 2:02 AM UTC

elevatedastalt wrote: post #118

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

The HN you are yearning for disappeared about 8-10 years ago when it was largely taken over by normies and people way outside the hard-core-tech fold. It's not very different from Reddit front-page now if the topic is even remotely political. For purely technical topics you expect good quality discussion, but those threads barely get comments in the two digits.

Yes sometimes the loudest voice definitely rises to the top and it’s annoying, but I also think it’s a condition that too many new members don’t know how to use the upvote button.

I also think it’s a symptom that HN does not allow enough people to use the down vote button. you could be a commenting member for years and not be able to downvote or you could be somebody who posts a few click bate links you copied from another aggregator and all of a sudden you have the ability to downvote. It’s pretty dumb.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#129

Post by [deleted] » Thu, Nov 21, 2024, 2:02 AM UTC

talkingtab wrote: post #96

It concerns me how discussions, such as this one go on HN. This is an important topic. With the epidemic of obesity we now find a drug that appeals to a large number of people. This is an important topic as well. What is the current comment receiving most of the comment? "That's the sort of headlines that smells like bullshit to me" That's the sort of comment that smells like bullshit to me. What kind of place is thi…

[deleted]

Re: Weight-loss drug found to shrink muscle in mice, human cells

#130

Post by vundercind » Thu, Nov 21, 2024, 2:03 AM UTC

hnthrowaway0328 wrote: post #22

cm2187 wrote: post #13

> emerging research showing that up to 40 per cent of the weight lost by people using weight-loss drugs is actually muscle That's the sort of headlines that smells like bullshit to me. My understand of those drugs is that they don't actually make you lose weight, they just cut your appetite so you can follow a diet to lose weight without hunger hammering at the door. So to start with, if that's the case, all they are…

Just curious, does your appetite come back whence you cut off the meds? The only reason I want to lose weight is to eat more freely, won't be useful if I lose my appetite too.

Experiences vary but I worried I’d, like, not enjoy food on it.

Nope, not a problem. I just get full much faster and am even more prone to simply not eating when I’m busy, than I already was. Not as food-focused when idle, but I still snack a little or whatever.