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Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

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Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#121

Post by VyseofArcadia »

llamaimperative wrote: post #107
VyseofArcadia wrote: post #99

Earlier quoted context omitted.

https://www.drugwatch.com/legal/ozempic-lawsuit/

Wow, someone experienced an adverse effect from a drug and are suing? This adds literally zero information.

Gastroparesis is a serious, life-threatening side effect.

It occurs in a small number of patients, sure, but maybe that just means I am more risk averse than you. My calculus is simple. I don't need wegovy. I can lose (and am losing) weight without it. Sure, it would be easier with wegovy, but it is not necessary. I am not going to take an unnecessary drug that has a nonzero chance of killing me.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#122

Post by rustcleaner »

Spooky23 wrote: post #55
declan_roberts wrote: post #8

How do you isolate this from the therapeutic benefits of simply losing weight and being skinny?

Omg, you figured it out! Shit. All we need to do is just tell a few million people to lose weight.

"That was Easy!"™

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#123

Post by aantix »

VyseofArcadia wrote: post #85
throwaway041207 wrote: post #36

Earlier quoted context omitted.

I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…

> barring any life threatening long term side effects There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. My father was on a long-term maintenance dose of immunosuppressant (I think prednisolone, but I could be misremembering) following his kidney transplant. When it was first prescribed to him, the long term side ef…

Exenatide, a GLP-1, was approved in 2005.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#124

Post by throwaway041207 »

93po wrote: post #112
throwaway041207 wrote: post #93

Earlier quoted context omitted.

I do not have ADHD. I am not sure exactly why I drink so much -- there are a number of alcoholics on both sides of my family, but I also spent many years drinking in bars in a big city, living a very social life. During COVID I became much more of a solitary drinker and over the last five or so years I have drank out of a sense of malaise. Every morning became the day I was going to take a break and every night there…

how long did you keep drinking after starting? thanks for response

No prob.

I noticed that I did not want to drink the day after my first shot. It was that fast. If anything the closest I came to drinking came from routine, not desire. That is to say, what is an afternoon watching football if not with a beer in hand? But I was able to move past that.

One thing I should make clear, no matter how heavy a drinker I have been at times in my life, including with liquor, I have never had a physical addiction. A person deep in the throws of physical addiction will need to approach this carefully.

If you are interested in this topic, I highly recommend reading this newsletter: https://recursiveadaptation.com/

There is a lot of great writing on this subject and some real world testimonies in there. Also happy to answer any more questions here.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#125

Post by cthalupa »

VyseofArcadia wrote: post #99
llamaimperative wrote: post #96

Earlier quoted context omitted.

> There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects. We've been prescribing GLP-1s for almost 20 years now. Not to say they all should behave identically, but from a Bayesian inference perspective these things really do appear to be quite safe.

https://www.drugwatch.com/legal/ozempic-lawsuit/

Risk factors for NAION are basically all the things that you go on these drugs to treat - type 2 diabetes, sleep apnea, cardiovascular disease, blood pressure, etc. One observational study that shows some correlation isn't enough for me to be particularly concerned about it.

> As of March 31, only 4 cases of gastroparesis were recorded for semaglutide—the active ingredient in Ozempic and Wegovy—in the FDA Adverse Event Reporting System (FAERS), a surveillance database updated by healthcare professionals, consumers, and manufacturers. For tirzepatide—the active ingredient in Mounjaro and Zepbound—there is just one case logged.

I don't have more recent numbers, but these seem pretty low.

I don't think anyone is saying that there is no chance of significant side effects in people, but when measured against the risks of being obese, they'd have to be very bad and impact a significant number of people taking the drug.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#126

Post by aantix »

voidfunc wrote: post #19
thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

Gonna be fun discovering what side effects it causes in 20 years tho.

Take a look at exenatide, a GLP-1 that was FDA-approved in 2005.

https://www.perplexity.ai/search/does-exenatide-lower-or-ext...

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#127

Post by balthigor »

EliRivers wrote: post #103
myprotegeai wrote: post #52

Earlier quoted context omitted.

Because you can buy sugar from the store, having the US subsidize ozempic for for the entire population makes logical sense. Got it.

Perhaps you could take your childishness elsewhere. It does grow tiring.

You are not the arbiter of what is "childish".

This style of condescension does grow tiring.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#128

Post by aantix »

mbostleman wrote: post #22
voidfunc wrote: post #19

Earlier quoted context omitted.

Gonna be fun discovering what side effects it causes in 20 years tho.

Exactly. I see all these breathless claims of new uses and how wonderful this drug is and wonder when the other shoe is going to drop.

You're getting downvoted because you didn't even care to do a simple Google search as to when the first GLP-1 was released. 2005. Almost 20 years.

We have the data.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#129

Post by cthalupa »

fgimenez wrote: post #119
thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

First-gen GLP-1 goes off patent in 2031 (e.g. semaglutide). Seems far off, but is frighteningly close for Novo. Tirzepatide gets genericized in 2039 and has better efficacy, which is why Lilly is in such a strong position right now. There is an enormous amount of biotech work to develop next-gen versions that have better half-lives, lower adverse events, and most importantly, have long patent lives. But it seems base…

Lilly is probably in an even stronger position if retatrutide continues to look as good as it has in the current trials. Better weight loss than tirzepatide, and recent results have shown it has excellent results on reducing fat deposits in the liver... and NAFLD is the leading cause of severe liver disease in the world.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#130

Post by rustcleaner »

curious_cat_163 wrote: post #11

> nationwide database of electronic health records (EHRs) of 116 million US patients. If you are expert in this space: Is such a dataset available publicly? If so, are there examples of other studies that have used this? Where does one go to read more about the mechanism of this study? Thanks!

I really really really wish my records were kept tight, offline, air gapped, or otherwise not stored on a cloud system with Trust Me Bro™ HIPAA-compliant security.

(The Trust Me Bro™ security aspect is the "It's secure because people will go to jail" and "We so totes won't use this easily subpoenaed data against you" security, when it would be best if the data stayed on a RAID in my doctor's office and an offsite VPN-linked backup instead. This goes 20x for psychs.)

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