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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#121

Post by jprete »

asib wrote: post #18
rqtwteye wrote: post #4

It's a pretty sad thought that everybody will be on a drug that keeps weight in check while most people will still eat a basically toxic diet. Weight is certainly an important factor but there is more to a healthy life.

Sure, but the "unhealthy but not excessively caloric" diet is not a problem ozempic attempts to address. As far as I understand, it simply limits your appetite. Potentially one can go on ozempic, lose weight, and still end up eating unhealthily, because the resulting diet is made up of nutritionally poor foods.

Ozempic does not simply limit your appetite, it seems to also affect how much reward your brain feels from different foods (and activities!), which would make it easier to override those anticipated rewards with conscious choices.

Re: How long til we're all on Ozempic?

#122

Post by nullc »

rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

Glad you're having a good time, but the broad ranging psychological effects are concerning.

Re: How long til we're all on Ozempic?

#123

Post by honkycat »

grecy wrote: post #94

My god no. I'm 42 and I've never taken more than the odd painkiller or antibiotic here or there - less than a pill a year on average I'm sure. The last thing in the world I want is to be permanently on some drug that alters how my body works. I hike, snowboard, go to the gym and eat sensibly. That's all the "weight control" I need.

Good for you man. 40% of the US is obese, we need a solution for better health outcomes.

Re: How long til we're all on Ozempic?

#124

Post by randomdata »

eightysixfour wrote: post #60
tredre3 wrote: post #36

Earlier quoted context omitted.

> big improvements for animal welfare Is it? It might reduce the amount of animals killed, sure, but it won't improve the well-being of the ones that are still raised.

This gets into a deep philosophical question people spend too much time arguing about. In short, some would argue suffering is multiplied by the number of sentient beings that experience it, others would argue only the average "amount" of suffering matters. You can end with some absurd paradoxes if you take either to their extremes. The reality is probably somewhere in the middle.

> In short, some would argue suffering is multiplied by the number of sentient beings that experience it

Factored by how cute the animal is. As a producer of plants for human consumption, it's quite obvious that orders of magnitude more animals are harmed in that process than are ever harmed in traditional meat production. But they're mostly ugly insects, so nobody cares.

Re: How long til we're all on Ozempic?

#125

Post by oldpersonintx »

arcticbull wrote: post #105
rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

[dead]

Re: How long til we're all on Ozempic?

#126

Post by pfdietz »

arcticbull wrote: post #105
rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> "Just eat less and exercise more" is trite. If it were that easy, we'd all be in fantastic shape. Studies show it just doesn't work. There was a massive (18,000,000 people) cohort analysis published in 2023 that showed the likelihood of someone losing 5% of their body weight in any given year was 1 in 11 and the likelihood of going from severely obese to normal weight is 1 in 1667. https://www.ncbi.nlm.nih.gov/pmc/…

I've lost 27 pounds since May (12%). Eliminating most carbs and doing lots of walking. I think being on metformin helped.

Re: How long til we're all on Ozempic?

#127

Post by mock-possum »

breck wrote: post #41

[flagged]

> “Is it bad for my liver to be off most of the time?” It's generally not healthy to keep your major organs in the off state. If you never open your eyes, you go blind.

I feel like this is missing the obvious follow up question, “is it bad for my liver to be on most of the time?”

Re: How long til we're all on Ozempic?

#128

Post by cyberax »

One other note: the current peptide-based GLP-1 drugs are not likely to be the permanent solution. Injectables are just too problematic for that.

Several companies are now working on more classic small-molecule drugs targeting the same receptors. So it's likely that in several years we'll get a pill with the same effects.

Yes, there's technically a pill version of Ozempic already (Rybelsus), but it works by making the stomach wall to be slightly permeable to peptides. You can guess that it has pretty unpleasant side effects, and an awesome bioavailability of 0.7%

Re: How long til we're all on Ozempic?

#129

Post by noch »

rootusrootus wrote: post #10

I'd think it more likely that it'll be one of the next generation drugs, but I do agree with the premise that it will be really common. A few weeks ago I started a low dose of tirzepatide (aka Mounjaro, aka Zepbound) and the side effects are interesting. The biggest negative, which just takes adjustment, is drastically lower stomach capacity. Used to be that two eggs and two pieces of toast was breakfast. Now I bette…

> Saturday is injection day, but Sunday is where it really becomes quite noticeable that I took it. Monday-Wednesday is cruising altitude and the effects are good but not over the top. Thursday I can feel it tapering, and today ... well, I'm looking forward to tomorrow's injection. I might switch to a twice-a-week split dose at some point to ease the peaks and valleys.

Perhaps coincidentally, this is similar to my experience with week long fasts: After 48 hours I feel like a precision missile cruising towards my target until about 5-6 days later.

But I will use a suitable GLP-1 based drug, because, man, fasting feels unbearably brutal for me after 6 days: profuse sweat, increased heart rate, brief but intense panic attacks, an insane level of sad (but not depressed) introspection, a hairpin trigger temper. I become a ridiculous mess. There's got to be a better way!

Thanks for sharing your experience and insight!

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