Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

GLP-1 pills are coming, and they could revolutionize weight-loss treatment

cnn.com

Post reply on HN
Print view View original

121–130 of 137 posts

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#121

Post by petesergeant »

unshavedyak wrote: post #66
JumpCrisscross wrote: post #43

Earlier quoted context omitted.

> many of the foods they still wanted would just make them sick immediately or hours later Can you name some of the foods? Never been on GLP-1 drugs. But a good amount of fast food leaves me feeling lethargic and, if I eat it too quickly, nauseated afterwards.

Their doctor suggested that they would drop a lot of weight fast, and they wanted to make sure they focused on eating lots of protein. So that's one restriction, medically prescribed meal types. On top of that, fatty meals, larger meals, and iirc fast carb heavy meals would all cause either nausea or diarrhea. Interestingly their mother is on the identical same generic GLP-1 shot, and has mostly the same side effects…

> On top of that, fatty meals, larger meals, and iirc fast carb heavy meals would all cause either nausea or diarrhea

It's worth pointing out that it's a minority of people who get any side-effects. I felt weird the first few days, but after that I only got myself into trouble if I'd forgotten to eat all day and then was faced with a hyper-satiating food with no natural portions -- an on-table buffet, someone placing endless bowls of chips and dips in front of me at a party, etc.

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#122

Post by petesergeant »

HarHarVeryFunny wrote: post #115
JumpCrisscross wrote: post #67

Earlier quoted context omitted.

> Diet and exercise don't have negative side effects and they are free They're absolutely not free. They fail at a high rate, which incurs medical costs. And when they work, they require--in practice--a lot of follow-up and coaching. It's fairy-tale level mindblowing that we can look at the status quo where nearly half of the industrialised world is obese and get haughty about a drug that medically, demonstrably impr…

Obesity is primarily a US problem. It's not the same in Europe, where people walk a lot more, and where portion sizes are normal. A ham and cheese sandwich in the UK would have a slice of ham and of cheese. In the US a deli sandwich is a monstrosity with about 1/4 pound of meat in it.

> Obesity is primarily a US problem

No no no. Obesity is very high in the US, but it's a big problem for lots of the world. It's a hard one to compare because different places use different cut-offs, but bringing this back to the UK: "64.0% of adults aged 18 years and over in England were estimated to be overweight or living with obesity [of which 40% are obese]"[0].

0: https://www.gov.uk/government/statistics/update-to-the-obesi...

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#123

Post by tmikaeld »

ct520 wrote: post #19
teqsun wrote: post #3

I'm curious: is the appetite suppressant effect of GLP-1 different from the one from amphetamines?

Yes. Having used both I can say indeed it is. Not only does GLP-1 slow digestion which limits what you can eat and when it also is being study for its effects on alcoholism etc reducing cravings. I and many people I know noticed the difference in cravings were not limited to food.

Does it affect libido?

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#125

Post by vundercind »

tmikaeld wrote: post #123
ct520 wrote: post #19

Earlier quoted context omitted.

Yes. Having used both I can say indeed it is. Not only does GLP-1 slow digestion which limits what you can eat and when it also is being study for its effects on alcoholism etc reducing cravings. I and many people I know noticed the difference in cravings were not limited to food.

Does it affect libido?

Oddly enough, no. It seems to affect a different desire pathway than dopamine and such. It’s not anhedonic, good stuff is still good and you still want it. Even food! It doesn’t make food not-pleasurable, just reduces hunger. It only seems to affect very particular kinds of cravings associated with food and addiction/compulsion, not sex drive (though maybe for “sex addicts”? IDK)

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#126

Post by vundercind »

bossyTeacher wrote: post #101
nkohari wrote: post #68

Earlier quoted context omitted.

> Sounds worrying to me as it means this is essentially a lifetime drug. As soon as you stop taking it, your appetite returns and so does your old weight. I see this said all the time about GLP-1 agonists, and it's a mischaracterization. It is true that when you stop taking the drug, your appetite is no longer suppressed, but you can still keep the weight off by eating a sustainable amount of calories. Usually, the b…

> you can still keep the weight off by eating a sustainable amount of calories. This was always true and we know this is not the reason why people are overweight

Some people can do ok maintaining weight for long stretches but have serious trouble getting back down if they slip and their weight shoots up.

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#127

Post by AmericanChopper »

JumpCrisscross wrote: post #91
AmericanChopper wrote: post #89

Earlier quoted context omitted.

Well the food addiction or sedentariness addiction diagnosis are a lot more controversial than a heroin addiction diagnosis, though I can see how they have some things in common. I think labelling any observable manifestation of poor impulse control as a medical addiction is more of a social trend than a legitimate scientific discovery. The bigger difference though is that we all eat food, and for most of us includes…

> labelling any observable manifestation of poor impulse control as a medical addiction is more of a social trend than a legitimate scientific discovery What gives you the confidence to overrule medical professionals on this? (Note: I am not a doctor and have zero medical training.) > We’re all (more or less) exposed to the “addictive substance”, it’s just some people have the ability to deprive ourselves constantly…

I’d say it stops being a useful descriptor at that point. If any activity that a person can possibly find rewarding in any way can be addictive, then everything is addictive. Because for any activity that you can possibly think of, you’ll find definitely find somebody who likes doing it.

By this criteria, I’m sure you’ll be able to find at least one eating glass addict somewhere in the world. But if we can stretch the definition to include glass as an addictive substance, then it kinda stops meaning anything at all.

And when I say these innovative addiction diagnoses are controversial, I mean within the community of clinical experts, which they are.

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#128

Post by EasyMark »

frankzander wrote: post #47

But why? Just eat no crap and work out. This is long lasting if it's a full life change.

If that worked we’d all be skinny and fit. Different people have different capacities to control their ability to balance food/nutritional intake of different qualities than others and it’s traceable both back to nature and nurture.

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#129

Post by unshavedyak »

petesergeant wrote: post #121
unshavedyak wrote: post #66

Earlier quoted context omitted.

Their doctor suggested that they would drop a lot of weight fast, and they wanted to make sure they focused on eating lots of protein. So that's one restriction, medically prescribed meal types. On top of that, fatty meals, larger meals, and iirc fast carb heavy meals would all cause either nausea or diarrhea. Interestingly their mother is on the identical same generic GLP-1 shot, and has mostly the same side effects…

> On top of that, fatty meals, larger meals, and iirc fast carb heavy meals would all cause either nausea or diarrhea It's worth pointing out that it's a minority of people who get any side-effects. I felt weird the first few days, but after that I only got myself into trouble if I'd forgotten to eat all day and then was faced with a hyper-satiating food with no natural portions -- an on-table buffet, someone placing…

Interesting to know. My sample size of two both have the same behaviors, and the GLP subreddits seem to validate the side effects finds as well iirc, but i'm just an outside observer so i've not dug deeply on this.

Re: GLP-1 pills are coming, and they could revolutionize weight-loss treatment

#130

Post by WesolyKubeczek »

JumpCrisscross wrote: post #77
WesolyKubeczek wrote: post #31

[flagged]

> Americans could probably start with putting less sugar into bloody everything and reducing portion sizes It's not just America. "Obesity in India has reached epidemic proportions in the 21st century, with morbid obesity affecting 5% of the country's population" [1]. (It's about 7% in America [2].) Meanwhile in China, "the incidence of overweight and obesity among school-age children...was 15.5% in 2010, rising to 2…

Which says that — if you choose to interpret things charitably and leave cost-cutting and profiteering out of it — the culinary tradition lags behind lifestyle changes severely. Urban populations largely don't have physically demanding, very manual jobs from dawn till dusk anymore, yet traditional portion sizes and composition of the dishes stay the same as they would be for heavy duty workers (I'm not speaking of abused workers or slaves here, mind you).

While you may interject that privileged classes used to have larger portions and better quality food without having to work so much at all times, it somehow coincides with fatty bellies being a status symbol in many locales. Being obese used to be a sort of privileged class mark.

Post reply on HN