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Viral DNA in the human genome linked to major psychiatric disorders

medicalxpress.com

121–130 of 141 posts

Re: Viral DNA in the human genome linked to major psychiatric disorders

#122

Amateur question: if we've retained these ostensibly dangerous or at least deleterious viral codes in our DNA, is there any reason why these virii don't serve a important evolutionary or remedial (maybe crisis) purpose?

Various illnesses are caused by promoter genes. These are genes that serve no purpose but they specialize in promoting themselves, so they spread through a population even though they serve no evolutionary fitness goal (often they bring illness). A good book on that topic:

Genes in Conflict: The Biology of Selfish Genetic Elements

by Austin Burt and Robert Trivers

https://www.amazon.com/gp/product/0674027221/

However, referring to the original article of this thread, it is also possible that the same genes that give us depression also give us something positive, such as creativity.

Re: Viral DNA in the human genome linked to major psychiatric disorders

#124

Earlier quoted context omitted.

Men who were prone to alternative/extreme states of consciousness would have been better able to summon up the wild emotions necessary for savagery and violence, making them better fighters and hence giving them better mating prospects.

somehow I doubt that someone with depression/bipolar disorder would be the best candidate to be a warrior

I dunno, high-functioning depression worked for the Japanese pretty well. Fear of death makes for a much less effective warrior in most circumstances.

Re: Viral DNA in the human genome linked to major psychiatric disorders

#125

Amateur question: if we've retained these ostensibly dangerous or at least deleterious viral codes in our DNA, is there any reason why these virii don't serve a important evolutionary or remedial (maybe crisis) purpose?

Various illnesses are caused by promoter genes. These are genes that serve no purpose but they specialize in promoting themselves, so they spread through a population even though they serve no evolutionary fitness goal (often they bring illness). A good book on that topic: Genes in Conflict: The Biology of Selfish Genetic Elements by Austin Burt and Robert Trivers https://www.amazon.com/gp/product/0674027221/ However…

This feels like a just-so story.

There are perfectly plausible reasons why the conditions we regard as mental illness are adaptations that help evolutionary fitness:

- Depression puts one into a low-energy, contemplative state that enables reflection, healing and formulation of reformed ways of thinking and being ("dark night of the soul");

- Bipiolar is a pattern of swinging between high-energy bursts of inspiration and creation, and low-energy states of recuperation and reflection;

- Schizophrenia is a way of disassociating from real-world experiences that are too painful to experience with normal consciousness, and is a preferable alternative (from an evolutionary perspective) to suicide, buying time for processing and healing to take place, given the right kind of support.

Of course, that could be seen as a "just so" story too. Except that evolutionary theory says that only genes that promote evolutionary fitness should survive and spread through the genome, particularly given that replication of any given gene carries a significant cost. We can also easily observe that conditions like depression and schizophrenia normally develop in response to a trigger - i.e., a traumatic life event or extended period of abuse.

So, it's far less of a confected story to just accept that these conditions have been retained in the genome for the reason that makes most sense according to evolutionary theory: it's evolutionarily beneficial for them to be there.

Re: Viral DNA in the human genome linked to major psychiatric disorders

#128

Is it possible to check for the presence/absence of these using data from 23andme?

The SNPs can be found in the supplement, so you could check this. But why? Probably it would make more sense to check all risk alleles known to be associated with e.g. bipolar disorder to test for your own risk.

Re: Viral DNA in the human genome linked to major psychiatric disorders

#129

Earlier quoted context omitted.

somehow I doubt that someone with depression/bipolar disorder would be the best candidate to be a warrior

why?

I know both pretty well, indirectly or not. Given how much they can influence your energy and "will to live" I don't think they'd pair well with having to fight for your life.
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