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First-in-human implantation of bionic device to halt Crohn's disease (2023)

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Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#121

Post by xtracto »

jjk166 wrote: post #80
munificent wrote: post #69

Earlier quoted context omitted.

We have so many cures that we simply forget about many diseases entirely.

Depending on how they are counted there are between 10000 and 70,000 different human diseases, and treatments only exist for around 500 of them. Further, the overwhelming majority of these treatments are not cures, i.e. treatments that end medical conditions in an individual.

Reminds me of GERD. It's a disease that affects a sizable group of people. It's a mechanical issue that is very well studied and known.

Yet, the main two treatment options are "workaround/hacks" or a very invasive operation.

There's only one [1] potential nobel "curing" treatment which is just gaining traction.

But innmy opinion with current technology, stuff like GERD or chronic bowel incontinence (due to mechanical failure of anjs sphincter) should be 100% solved.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624249/

Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#122

Post by polishdude20 »

matheweis wrote: post #118
Centigonal wrote: post #89

Earlier quoted context omitted.

IBDs like Crohn's and Ulcerative Colitis have increased in incidence (controlling for better diagnosis) as countries develop[1] [2]. People in developing countries have a lower rate of incidence, and if they move to developed countries, the incidence remains low. However, their children, born in developed countries, experience the higher rate of incidence. Something about being a child in a developed country increase…

> It's also interesting to note many food allergies have increased in prevalence in the last 30 years Wonder how much of this is due to the relatively recent trend of having dual incomes with both parents working? Cause and effect might be hard to tease out but it’s looking like there are some drastic differences in babies that were born early in the pandemic: > only about 5% of the lockdown babies had developed a fo…

Breast milk? Or maybe literal live breast feeding? Mouth on mother's skin and all that.

Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#123

Post by polishdude20 »

cjdell wrote: post #24

I initially wrote this as a reply to a comment by "NotGMan" mentioning fasting/paleo that got flagged. They could have approached the subject more delicately but I believe they have a point. About 3 years ago I had gut issues so bad I thought I was close to death. NHS couldn't see any problems and were basically telling me I'd gone nuts. They refused to do any further testing. After a year of suffering I tried a 7 da…

Have you noticed any trigger foods since then?

I'm kind in the same boat as you were in. Nothing live threatening but definitely daily annoyance of gut issues that impacts my life.

Mind sharing some meals you eat for breakfast, lunch, dinner? I'd love to try some new healthier options.

Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#124

Post by polishdude20 »

semi-extrinsic wrote: post #106
CWuestefeld wrote: post #77

Earlier quoted context omitted.

I don't recommend everyone follow the same diet, but for whatever it's worth, eating junk food has helped my relative, true story. Crohn's disease affects each patient differently. Depending on what part of the gut is being attacked [1], different digestive processes are implicated. That will lead to different kinds of foods being potentially problematic (as well as leading to a need for different kinds of supplement…

The "your mileage will vary" part is definitely true, as well as the "incredible what kinds of pain you can get used to". I had 30 cm of my upper intestine removed 12 years ago. Doctors said it was so constricted you couldn't pass a pencil through, but I was still managing to ski double black diamonds two weeks before surgery. When it comes to fiber in particular, I think what can confuse people is the difference bet…

I wonder if water balance plays a big role. Like, you drink water but it easily gets absorbed by your stomach or small intestine before it gets a chance to work it's way down with the food. Then as the food is passing through, the water dries up. It's as if your body wants the water more than the intestines. Drinking the extra water with the nuts may help because of that? Just spiralling

Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#125

Post by polishdude20 »

asdfqwertzxcv wrote: post #107
semi-extrinsic wrote: post #106

Earlier quoted context omitted.

The "your mileage will vary" part is definitely true, as well as the "incredible what kinds of pain you can get used to". I had 30 cm of my upper intestine removed 12 years ago. Doctors said it was so constricted you couldn't pass a pencil through, but I was still managing to ski double black diamonds two weeks before surgery. When it comes to fiber in particular, I think what can confuse people is the difference bet…

Have Chron's with stricturing and anything more than a quarter cup of corn, popcorn, pineapple or leafy greens would bring me to my knees in about 5-8 hours. Nuts are a little hit or miss, I need to chew them up really well and not eat them on an empty stomach and I'm good for a few handfuls. I tell people that if it looks the same coming out as it goes in, I can't have that banging around my guts. Any fast or junk f…

I wonder if that's something I should do. I noticed once or twice if I ate something with pumpkin puree in it, the next day my bowels were heavenly.

Do you have a different reaction to soluble vs insoluble fiber?

Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#126

Post by polishdude20 »

hanniabu wrote: post #48
SirMaster wrote: post #32

Earlier quoted context omitted.

>I think there are other foods that bother different people, but we haven't managed pin down exactly which foods bother which people. It's a hard problem Sounds like a job for a neural net. If people would log all what they eat and how they feel. If the neural net had access to all the components of the foods they are inputting, surely with enough data a pattern would emerge of what common component in what they eat…

Not that easy. I have sibo and depending on what I eat and how I eat it, it changes the effects it has on me. Also the amount and frequency. For example, if I have raisins at the start of my meal then I don't see issues, but if I have them at the end of my meal then I do. If I have it here and there then no issues, but if I have it a few meals in a row then it'll give me issues. And raisins affect me within 20min, bu…

I thought sibo was fairly treatable with antibiotics? Or is it a recurring thing that just won't go away?

Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#127

Post by asdfqwertzxcv »

polishdude20 wrote: post #125
asdfqwertzxcv wrote: post #107

Earlier quoted context omitted.

Have Chron's with stricturing and anything more than a quarter cup of corn, popcorn, pineapple or leafy greens would bring me to my knees in about 5-8 hours. Nuts are a little hit or miss, I need to chew them up really well and not eat them on an empty stomach and I'm good for a few handfuls. I tell people that if it looks the same coming out as it goes in, I can't have that banging around my guts. Any fast or junk f…

I wonder if that's something I should do. I noticed once or twice if I ate something with pumpkin puree in it, the next day my bowels were heavenly. Do you have a different reaction to soluble vs insoluble fiber?

No real difference for me. It mostly comes down to quantity, speed and how much it’s broken down by chewing, cooking or blending.

Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#128

Post by TheLML »

computer7050 wrote: post #67
jml78 wrote: post #58

Earlier quoted context omitted.

That is one she has been on in the past. She has gone thru about 8 trying to find one that works best for her. She is currently on tremfya

Thanks for the response. I have a family member about to start on Rinvoq and cancer risk is weighing on my mind as well.

I've been on Rinvoq since last summer and I delayed getting on it for that very reason. Reading the risks was really not making me feel well, after I've already taken multiple other medications. The worst part is, that it doesn't work as perfectly as some previous meds have. But at least I can enjoy eating out occasionally again without much worry and can travel again. That quality of life improvement puts it into a slightly better perspective again.

Re: First-in-human implantation of bionic device to halt Crohn's disease (2023)

#129

Post by naruhodo »

hanniabu wrote: post #117
naruhodo wrote: post #111

Earlier quoted context omitted.

Yeah. And I suspect diet. There has been some speculation that the "safe" levels of herbicide are not actually safe for beneficial gut flora.

> And I suspect diet Of course, your diet influences your gut health

I should have phrased that better. I meant "the safety of food in one's diet" rather than "the tips of food constituting one's diet".
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