For many of us, running our code 1 billion times will cost less than a few minutes of a developer's time. Hell, I could spend $200 for a month of server time on AWS and run a lot of my (web API) code 100 billion times. Optimizing for human readers is always better until you're working on something that proves itself to be too slow to be economical anymore.
user > ops > dev
biz > ops > dev
biz ≹ user
The conclusion seems to be that code exists in service to the end-user and the business. The last equation (≹) is a neat way of describing that both end-user and the business are equally important to the existence of the code, even though their needs aren’t the same.