Earlier quoted context omitted.
> DNS is probably 2 round trips (CNAME then A), and that has to cross the ocean via your resolver of choice I hope your DNS doesn't have to do that. Most anycast DNS should have lots of PoPs (regions) and are really fast. CDNs usually solve a lot of the static asset issues. The main issue is the database.
People should use their ISP's DNS as well which is often <5ms. I've never bothered using an off-net DNS provider for this reason given how much faster is it to use an on-net caching DNS resolver provided by my ISP.
Also, they often run a single instance of bind, with little to no load-balancing.